Biophotonics: Photonic Solutions for Better Health Care II

The widespread introduction of laser noninvasive diagnostic techniques in medicine gave rise interest to theoretical description of light propagation in turbid media. One of the purposes for that is a preliminary simulation of incoming radiation for diagnostic spectrophotometry equipment. For complex diagnostic devices combining the Laser Doppler Flowmetry (LDF) and the tissue reflectance oximetry (TRO) it is necessary to know a ratio of signals in each diagnostic channel for a proper choice of the radiation power of laser sources, sensitivity of photodetectors, etc. In LDF the lightbeating backscattered signal mixed from moving red blood cells and static inhomogeneities inside the tissue is the useful signal, while in TRO both signals from static and moving scatterers are registered in the sum. The aim of our study was an estimation of the ratio between flux with the Doppler shifted signal and the total backscattered flux. For this purpose the simple analytical model describing the backscattered radiation for a two-layered tissue with different levels of blood volume in the second layer was under consideration. The physical model was based on the improved Kubelka-Munk approach. This approach involves an additional parameter of the density of scatterers, so it is useful for the Doppler signal intensity calculation as well. To assess the intensity of the Doppler component the single-scattering approximation inside the tissue’s second layer was used. It was found that the fraction of the Doppler component in the total backscattered flux can vary in the range of 1-10% for the blood volume of 1-20%.

[1]  R. Nossal,et al.  Model for laser Doppler measurements of blood flow in tissue. , 1981, Applied optics.

[2]  Félix Fanjul-Vélez,et al.  Analysis of optical crosstalk in flexible imaging endoscopes based on multicore fibers , 2010, Photonics Europe.

[3]  J. Spigulis,et al.  Real-time analysis of skin capillary-refill processes using blue LED , 2010, Photonics Europe.

[4]  Arnaud Dubois,et al.  Full-field optical coherence tomography at 800 nm and 1300 nm simultaneously , 2010, Photonics Europe.

[5]  A specific feature of the procedure for determination of optical properties of turbid biological tissues and media in calculation for noninvasive medical spectrophotometry , 2007 .

[6]  I. S. Saidi,et al.  Transcutaneous Optical Measurement of Hyperbilirubinemia in Neonates , 1992 .

[7]  Iulian Ionita,et al.  Biotissue structure investigation using ultra-short pulsed laser polarimetry , 2010, Photonics Europe.

[8]  V. I. Shumskiy,et al.  Multifunctional laser noninvasive spectroscopic system for medical diagnostics and some metrological provisions for that , 2009, European Conference on Biomedical Optics.

[9]  V. Rajan,et al.  Review of methodological developments in laser Doppler flowmetry , 2009, Lasers in Medical Science.

[10]  Christian Depeursinge,et al.  Determination of local optical properties of the rat barrel cortex during neural activation: Monte-Carlo approach to light propagation , 2010, Photonics Europe.

[11]  Victor V. Fadeev,et al.  Fluorescent diagnostics of cyanobacteria , 2010, Photonics Europe.

[12]  Masayuki Saiki,et al.  Selective removal of carious dentin using a nanosecond pulsed laser with a wavelength of 6.02 μm , 2010, Photonics Europe.

[13]  Vasilis Ntziachristos,et al.  High resolution single-mode-fiber-based sensor for intravascular detection of fluorescent molecular probes , 2010, Photonics Europe.

[14]  Hans-Gerd Lipinski,et al.  3D topology and arrangement of proteins inside ceramide-rich domains , 2010, Photonics Europe.

[15]  A. S. Martirosyan,et al.  Possibility of improvement of hemoglobin properties as biosensors' detection element , 2010, Photonics Europe.

[16]  M. Portaccio,et al.  FT-IR microspectroscopy characterization of supports for enzyme immobilization in biosensing applications , 2010, Photonics Europe.

[17]  Edmund Koch,et al.  Combining optical coherence tomography with fluorescence microscopy: a closer look into tissue , 2010, Photonics Europe.

[18]  Dmitrii Alekseevich Rogatkin,et al.  On one simple backscattering task of the general light scattering theory , 2004, Saratov Fall Meeting.

[19]  Luis Cláudio Suzuki,et al.  Real time optical coherence tomography monitoring of Candida albicans biofilm in vitro during photodynamic treatment , 2010, Photonics Europe.

[20]  Pablo Loza-Alvarez,et al.  Assessing structural characteristics of axons in cortical neurons using polarization sensitive SHG , 2010, Photonics Europe.

[21]  Alexandre Douplik,et al.  Monitoring of the vessel capillary density spatial pattern in epithelium phantom model , 2010, Photonics Europe.

[22]  Jürgen Popp,et al.  Utilizing of anisotropic plasmonic arrays for analytics , 2010, Photonics Europe.

[23]  Tobias Meyer,et al.  Biomedical imaging by means of linear and non-linear Raman microspectroscopy , 2010, Photonics Europe.

[24]  Darius Schippritt,et al.  Sedimentation of agglomerated nanoparticles under cell culture conditions studied by image based analysis , 2010, Photonics Europe.

[25]  W. Fritzsche,et al.  Easy characterization of SERS substrates of enzymatically produced silver nanoparticles and their applications in the area of bioanalytics , 2010, Photonics Europe.

[26]  Luis M. Bernardo,et al.  Detection of colon and rectum cancers by terahertz techniques , 2010, Photonics Europe.

[27]  Emer Kenny,et al.  Non-contact measurement of ocular microtremor using laser speckle , 2010, Photonics Europe.

[28]  N. Ortega-Quijano,et al.  Photochemical predictive analysis of photodynamic therapy with non-homogeneous topical photosensitizer distribution in dermatological applications , 2010, Photonics Europe.

[29]  Pablo Loza-Alvarez,et al.  Optical extraction of the helical pitch angle of amylopectin in starch , 2010, Photonics Europe.

[30]  Akira Ishimaru,et al.  Wave propagation and scattering in random media. Volume I - Single scattering and transport theory , 1978 .

[31]  Janis Spigulis,et al.  Multi-spectral mapping of in vivo skin hemoglobin and melanin , 2010, Photonics Europe.

[32]  Jürgen Popp,et al.  Fabrication of regular patterned SERS arrays by electron beam lithography , 2010, Photonics Europe.

[33]  Claudia Heilmann,et al.  Implantable reflectance pulse transit time blood pressure sensor with oximetry capability , 2010, Photonics Europe.

[34]  Vincent Moreau,et al.  Comparison of spectral colorimetric measurements vs. color pictures in dermatology , 2010, Photonics Europe.

[35]  I. Delfino,et al.  Micro-Raman spectroscopy of tissue samples for oral pathology follow-up monitoring , 2010, Photonics Europe.

[36]  T. Gostev,et al.  Phytoplankton as a fluorescent bioindicator of ecotoxicants in natural waters , 2010, Photonics Europe.

[37]  Y. Xie,et al.  Fiber spectral domain optical coherence tomography for in vivo rat brain imaging , 2010, Photonics Europe.

[38]  Jürgen Popp,et al.  Two channel microfluidic CARS for quantifying pure vibrational contrast of model analytes , 2010, Photonics Europe.