The Complex Interplay between Antioxidants and ROS in Cancer.
暂无分享,去创建一个
[1] G. DeNicola,et al. Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function , 2020, The Journal of experimental medicine.
[2] D. Boothman,et al. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone , 2020, Redox biology.
[3] D. Tuveson,et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer , 2020, Cancer cell.
[4] E. Robert McDonald,et al. Quantitative Proteomics of the Cancer Cell Line Encyclopedia , 2020, Cell.
[5] Shakeel U. R. Mir,et al. Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression. , 2019, Free radical biology & medicine.
[6] Jingyan Han,et al. Redox regulation via glutaredoxin-1 and protein S-glutathionylation. , 2019, Antioxidants & redox signaling.
[7] Fan Yang,et al. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway , 2019, Journal of Experimental & Clinical Cancer Research.
[8] Edward W. Tate,et al. FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.
[9] J. Olzmann,et al. The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis , 2019, Nature.
[10] K. Vousden,et al. Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization , 2019, Cell metabolism.
[11] A. Viale,et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase , 2019, Cell.
[12] Natalie M. Mishina,et al. Which Antioxidant System Shapes Intracellular H2O2 Gradients? , 2019, Antioxidants & redox signaling.
[13] M. Bergo,et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis , 2019, Cell.
[14] B. Ueberheide,et al. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1 , 2019, Cell.
[15] B. Stockwell,et al. Intercellular interaction dictates cancer cell ferroptosis via Merlin-YAP signalling , 2019, Nature.
[16] S. Eriksson,et al. TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy , 2019, Proceedings of the National Academy of Sciences.
[17] John G Doench,et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. , 2019, Cell metabolism.
[18] G. G. Galli,et al. The landscape of cancer cell line metabolism , 2019, Nature Medicine.
[19] Emanuel J. V. Gonçalves,et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens , 2019, Nature.
[20] J. Rabinowitz,et al. Serine Metabolism Supports Macrophage IL-1β Production. , 2019, Cell metabolism.
[21] J. Rabinowitz,et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism , 2019, Nature Metabolism.
[22] D. Sabatini,et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death , 2019, Nature.
[23] C. Chelala,et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion , 2018, Developmental cell.
[24] J. Asara,et al. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer , 2018, bioRxiv.
[25] K. Tenbrock,et al. Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression , 2018, Front. Immunol..
[26] Christian M. Metallo,et al. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma , 2018, Cell.
[27] Hong Jiang,et al. Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis. , 2018, Cancer letters.
[28] P. Schultz,et al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signaling , 2018, Nature.
[29] Michael D. Pluth,et al. Cytochrome c Reduction by H2S Potentiates Sulfide Signaling. , 2018, ACS chemical biology.
[30] Y. Urano,et al. N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production. , 2018, Cell chemical biology.
[31] C. Orengo,et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells , 2018, The Biochemical journal.
[32] Matthew E. Ritchie,et al. Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment. , 2018, Cell metabolism.
[33] Michael D. Brooks,et al. Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. , 2018, Cell metabolism.
[34] Anton Simeonov,et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy , 2018, Science Translational Medicine.
[35] M. Karin,et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. , 2017, Cancer cell.
[36] I. DikalovSergey,et al. Electron Paramagnetic Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine Spin Probes , 2017 .
[37] M. Mintun,et al. Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation , 2017, ACS chemical neuroscience.
[38] D. Sabatini,et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis , 2017, Nature.
[39] Benjamin F. Cravatt,et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer , 2017, Cell.
[40] B. Stockwell,et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease , 2017, Cell.
[41] Francisco J. Sánchez-Rivera,et al. Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis , 2017, Nature Medicine.
[42] R. Deberardinis,et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis , 2017, Nature.
[43] Jill P. Mesirov,et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway , 2017, Nature.
[44] Stuart L. Schreiber,et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition , 2017, Nature.
[45] S. Gygi,et al. The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival , 2017, Nature.
[46] Christopher D. McFarland,et al. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo , 2017, Nature Methods.
[47] T. Mak,et al. Glutathione Primes T Cell Metabolism for Inflammation , 2017, Immunity.
[48] M. Duchen,et al. Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells , 2017, The Biochemical journal.
[49] A. Warnatsch,et al. Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size , 2017, Immunity.
[50] X. Mao,et al. Glutathione-s-transferase A 4 (GSTA4) suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting AKT pathway. , 2017, American journal of translational research.
[51] H. Sies. Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress☆ , 2017, Redox biology.
[52] J. Zubieta,et al. Preparation of an 18 F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species. , 2017, Chemistry.
[53] M. Dore,et al. Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia , 2016, Medicine.
[54] Leonard D. Goldstein,et al. Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers. , 2016, Cell reports.
[55] Brandon Da Silva,et al. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer , 2016, Cell.
[56] T. Akaike,et al. The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation. , 2016, Free radical biology & medicine.
[57] Christian M. Metallo,et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth , 2016, Nature.
[58] B. Faubert,et al. Metabolic Heterogeneity in Human Lung Tumors , 2016, Cell.
[59] O. Sansom,et al. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine , 2016, Genes & development.
[60] Eugenia G. Giannopoulou,et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH , 2015, Science.
[61] R. Deberardinis,et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer , 2015, Nature Genetics.
[62] M. Bergo,et al. Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.
[63] R. Deberardinis,et al. Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.
[64] R. Banerjee,et al. Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways. , 2015, Nature chemical biology.
[65] D. Sabatini,et al. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.
[66] Elaine Fuchs,et al. TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma , 2015, Cell.
[67] S. Eriksson,et al. Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver , 2015, Nature Communications.
[68] S. Inoue,et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.
[69] S. Altekruse,et al. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma , 2015, Clinical Cancer Research.
[70] S. Knapp,et al. Abstract IA09: Copper is required for oncogenic BRAF signaling and tumorigenesis , 2014 .
[71] D. Wink,et al. Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility. , 2014, Free radical biology & medicine.
[72] Christopher J. Chang,et al. A Boronate-Caged [18F]FLT Probe for Hydrogen Peroxide Detection Using Positron Emission Tomography , 2014, Journal of the American Chemical Society.
[73] Hong Jiang,et al. Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. , 2014, American journal of cancer research.
[74] T. Copetti,et al. A mitochondrial switch promotes tumor metastasis. , 2014, Cell reports.
[75] T. Shlomi,et al. Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.
[76] Adam M. Feist,et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. , 2014, Molecular cell.
[77] N. Colburn,et al. Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis. , 2014, Carcinogenesis.
[78] Lucio Luzzatto,et al. G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications , 2014, British journal of haematology.
[79] E. Larsson,et al. Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.
[80] Matthew E. Welsch,et al. Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.
[81] A. Holmgren,et al. The thioredoxin antioxidant system. , 2014, Free radical biology & medicine.
[82] Andrea Glasauer,et al. Targeting SOD1 reduces experimental non–small-cell lung cancer. , 2014, The Journal of clinical investigation.
[83] E. White,et al. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. , 2013, Cancer discovery.
[84] S. Florian,et al. Deletion of Glutathione Peroxidase-2 Inhibits Azoxymethane-Induced Colon Cancer Development , 2013, PloS one.
[85] Kwok-Kin Wong,et al. Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. , 2013, The Journal of clinical investigation.
[86] Gabriela Kalna,et al. ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation , 2013, Cell stem cell.
[87] G. Piazza,et al. An Undesired Effect of Chemotherapy , 2013, The Journal of Biological Chemistry.
[88] S. Werner,et al. Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis. , 2013, Cancer research.
[89] John M. Asara,et al. Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.
[90] Caitlyn W. Barrett,et al. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. , 2013, Cancer research.
[91] Karen Blyth,et al. Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells , 2012, Nature.
[92] H. Aburatani,et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. , 2012, Cancer cell.
[93] M. R. Lamprecht,et al. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.
[94] G. Sauvageau,et al. A role for GPx3 in activity of normal and leukemia stem cells. , 2012 .
[95] P. Chakravarty,et al. Increased skin papilloma formation in mice lacking glutathione transferase GSTP. , 2011, Cancer research.
[96] P. Carmeliet,et al. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling , 2011, Cancer cell.
[97] N. Grishin,et al. Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. , 2011, Cancer cell.
[98] Scott E. Kern,et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.
[99] Jorming Goh,et al. Mitochondrial targeted catalase suppresses invasive breast cancer in mice , 2011, BMC Cancer.
[100] Linda Partridge,et al. Unraveling the biological roles of reactive oxygen species. , 2011, Cell metabolism.
[101] G. Bornkamm,et al. Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation. , 2010, Cancer research.
[102] Q. Wei,et al. Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. , 2010, Journal of the National Cancer Institute.
[103] E. Kremmer,et al. System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency* , 2010, The Journal of Biological Chemistry.
[104] W. Wheaton,et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.
[105] E. White,et al. A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 , 2010, Molecular and Cellular Biology.
[106] Mihee M. Kim,et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 , 2010, Nature Cell Biology.
[107] O. Sansom,et al. Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi , 2009, Proceedings of the National Academy of Sciences.
[108] Yan Li,et al. Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.
[109] Hanna Y. Irie,et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.
[110] Peng Huang,et al. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.
[111] M. Cha,et al. Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma , 2009, Journal of experimental & clinical cancer research : CR.
[112] Elias S. J. Arnér. Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions. , 2009, Biochimica et biophysica acta.
[113] N. Leslie,et al. Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity , 2009, The EMBO journal.
[114] Irving L. Weissman,et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells , 2009, Nature.
[115] M. McMahon,et al. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. , 2009, Trends in biochemical sciences.
[116] Shelly C. Lu. Regulation of glutathione synthesis. , 2009, Molecular aspects of medicine.
[117] J. Crowley,et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). , 2009, JAMA.
[118] A. Townsend,et al. Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin , 2008, Molecular Cancer Therapeutics.
[119] C. Winterbourn,et al. Thiol chemistry and specificity in redox signaling. , 2008, Free radical biology & medicine.
[120] Rui Wang,et al. Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. , 2008, Biochemical and biophysical research communications.
[121] Rogerio Margis,et al. Glutathione peroxidase family – an evolutionary overview , 2008, The FEBS journal.
[122] J. Hayashi,et al. ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis , 2008, Science.
[123] M. Cappellini,et al. Glucose-6-phosphate dehydrogenase deficiency , 2008, The Lancet.
[124] M. Trujillo,et al. Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. , 2007, Archives of biochemistry and biophysics.
[125] Jonathan Pevsner,et al. HIF-dependent antitumorigenic effect of antioxidants in vivo. , 2007, Cancer cell.
[126] Jinsong Liu,et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.
[127] Eyal Gottlieb,et al. TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis , 2006, Cell.
[128] P. Chumakov,et al. The antioxidant function of the p53 tumor suppressor , 2005, Nature Medicine.
[129] D. Albertson,et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability , 2005, Nature.
[130] Michael M Lieber,et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). , 2005, Journal of the National Cancer Institute.
[131] V. Vasiliou,et al. Analysis of the glutathione S-transferase (GST) gene family , 2004, Human Genomics.
[132] C. Epstein,et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. , 2003, Physiological genomics.
[133] S. Orkin,et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression , 2003, Nature.
[134] T. Tsuzuki,et al. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. , 2003, Cancer research.
[135] Benjamin P Tu,et al. The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. , 2002, Molecular cell.
[136] D. Albanes,et al. Selenium, vitamin E, and prostate cancer--ready for prime time? , 1998, Journal of the National Cancer Institute.
[137] A. Townsend,et al. Coordinated Action of Glutathione S-Transferases (GSTs) and Multidrug Resistance Protein 1 (MRP1) in Antineoplastic Drug Detoxification , 1998, The Journal of Biological Chemistry.
[138] G. Paine-Murrieta,et al. Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells. , 1996, Cancer research.
[139] J. Imlay,et al. Superoxide accelerates DNA damage by elevating free-iron levels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[140] C. Winterbourn. Toxicity of iron and hydrogen peroxide: the Fenton reaction. , 1995, Toxicology letters.
[141] B. Ames,et al. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[142] I. Hirono. Mechanism of natural and acquired resistance to methyl-bis-(beta-chlorethyl)-amine N-oxide in ascites tumors. , 1961, Gan.
[143] F. Figge. Cosmic Radiation and Cancer. , 1947, Science.
[144] Jacob D. Jaffe,et al. Next-generation characterization of the Cancer Cell Line Encyclopedia , 2019, Nature.
[145] A. Masamune,et al. Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma. , 2018, American journal of physiology. Gastrointestinal and liver physiology.
[146] Brian J. Smith,et al. O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. , 2017, Cancer cell.
[147] Shelly C. Lu. Glutathione synthesis. , 2013, Biochimica et biophysica acta.
[148] J. Crowley,et al. Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial ( SELECT ) , 2011 .
[149] M. Aitio. N-acetylcysteine -- passe-partout or much ado about nothing? , 2006, British journal of clinical pharmacology.
[150] J. D. Engel,et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.
[151] D. Albanes,et al. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.
[152] Riley Pa. Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation , 1994 .
[153] P. Riley. Free radicals in biology: oxidative stress and the effects of ionizing radiation. , 1994, International journal of radiation biology.