Keratinocyte growth factor: a unique player in epithelial repair processes.

[1]  D. Lacey,et al.  Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. , 1998, Cancer research.

[2]  T. Arakawa,et al.  Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. , 1998, Biochemical and biophysical research communications.

[3]  P. Finch,et al.  Altered expression of keratinocyte growth factor and its receptor in psoriasis. , 1997, The American journal of pathology.

[4]  J. Rubin,et al.  Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries , 1997, Journal of cellular physiology.

[5]  S. Werner,et al.  Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression , 1997, Oncogene.

[6]  S. Werner,et al.  A novel type of glutathione peroxidase: expression and regulation during wound repair. , 1997, The Biochemical journal.

[7]  S. Knox,et al.  Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor. , 1997, Radiation research.

[8]  J. Weiner,et al.  A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. , 1997, Development.

[9]  R. Mohan,et al.  IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: interleukin-1 beta expression in the cornea. , 1997, Cornea.

[10]  D. Kamp,et al.  KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. , 1997, The American journal of physiology.

[11]  S. Hayward,et al.  Growth factors in bladder wound healing. , 1997, The Journal of urology.

[12]  B. Guery,et al.  Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs. , 1997, American journal of respiratory and critical care medicine.

[13]  R. Deterding,et al.  Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor. , 1997, Proceedings of the Association of American Physicians.

[14]  C. Waters,et al.  KGF prevents hydrogen peroxide-induced increases in airway epithelial cell permeability. , 1997, The American journal of physiology.

[15]  S. Werner,et al.  The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene , 1997, Oncogene.

[16]  D. Lacey,et al.  Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. , 1997, Cancer research.

[17]  N. Fusenig,et al.  Interleukin-1-induced growth factor expression in postmitotic and resting fibroblasts. , 1996, The Journal of investigative dermatology.

[18]  T. Ulich,et al.  Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. , 1996, The American journal of pathology.

[19]  P. Finch,et al.  Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair. , 1996, The American journal of physiology.

[20]  R. Deterding,et al.  Keratinocyte growth factor reduces lung damage due to acid instillation in rats. , 1996, American journal of respiratory cell and molecular biology.

[21]  J. Nathans,et al.  Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Hofschneider,et al.  Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease. , 1996, The American journal of pathology.

[23]  N. Itoh,et al.  Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[24]  S. Werner,et al.  Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. , 1996, Cytokine.

[25]  C. MacArthur,et al.  Receptor Specificity of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[26]  R. Galiano,et al.  Keratinocyte growth factor induces granulation tissue in ischemic dermal wounds. Importance of epithelial-mesenchymal cell interactions. , 1996, Archives of surgery.

[27]  B. Guery,et al.  Keratinocyte growth factor attenuates lung leak induced by alpha-naphthylthiourea in rats. , 1996, Critical care medicine.

[28]  J. Rubin,et al.  Glucocorticoids inhibit keratinocyte growth factor production in primary dermal fibroblasts. , 1996, Endocrinology.

[29]  N. Bucay,et al.  Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations. , 1996, Oncogene.

[30]  D. Lacey,et al.  Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. , 1996, Gastroenterology.

[31]  G. Martin,et al.  Fibroblast growth factor signalling in the hair growth cycle: Expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[32]  S. Finkelstein,et al.  Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. , 1996, Gastroenterology.

[33]  E. Fuchs,et al.  Keratinocyte growth factor is required for hair development but not for wound healing. , 1996, Genes & development.

[34]  D. Danilenko,et al.  Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor. , 1995, The American journal of pathology.

[35]  K. Csaky,et al.  Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin , 1995, The Journal of experimental medicine.

[36]  D. Lacey,et al.  Keratinocyte growth factor causes proliferation of urothelium in vivo. , 1995, The Journal of urology.

[37]  J. Rubin,et al.  Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. , 1995, The Journal of clinical investigation.

[38]  S. Werner,et al.  Suppression of keratinocyte growth factor expression by glucocorticoids in vitro and during wound healing. , 1995, The Journal of investigative dermatology.

[39]  J. Rubin,et al.  Keratinocyte growth factor increases mRNAs for SP-A and SP-B in adult rat alveolar type II cells in culture. , 1995, The American journal of physiology.

[40]  D. Danilenko,et al.  Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. , 1995, The American journal of pathology.

[41]  J. Firth,et al.  Keratinocyte growth factor stimulation of gelatinase (matrix metalloproteinase-9) and plasminogen activator in histiotypic epithelial cell culture. , 1995, The Journal of investigative dermatology.

[42]  J. Rubin,et al.  Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[43]  C. Lengel,et al.  Cloning and characterization of the promoter region of the human keratinocyte growth factor gene , 1995, The Journal of Biological Chemistry.

[44]  J. Rubin,et al.  Keratinocyte growth factor , 1995, Cell biology international.

[45]  W. Havran,et al.  Modulation of epithelial cell growth by intraepithelial gamma delta T cells. , 1994, Science.

[46]  P. Hofschneider,et al.  The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. , 1994, Science.

[47]  S. Werner,et al.  Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. , 1994, Oncogene.

[48]  R. Whitehead,et al.  Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. , 1994, The Journal of clinical investigation.

[49]  S. Werner,et al.  Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. , 1994, The Journal of investigative dermatology.

[50]  R. Cardiff,et al.  Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. , 1994, The American journal of pathology.

[51]  S Tsunekawa,et al.  Fibroblast growth factors modulate intestinal epithelial cell growth and migration. , 1994, Gastroenterology.

[52]  J. Xu,et al.  Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. , 1994, The Journal of biological chemistry.

[53]  J. Rubin,et al.  Regulation of keratinocyte growth factor gene expression by interleukin 1. , 1994, The Journal of biological chemistry.

[54]  D. Danilenko,et al.  Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor , 1994, The Journal of experimental medicine.

[55]  J. A. Quayle,et al.  Cytokine expression by inflammatory neutrophils. , 1994, FEMS immunology and medical microbiology.

[56]  F. Fuller-Pace,et al.  FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions , 1994, Mechanisms of Development.

[57]  H. Ueno,et al.  Dominant-negative mutations of platelet-derived growth factor (PDGF) receptors. Inhibition of receptor function by ligand-dependent formation of heterodimers between PDGF alpha- and beta-receptors. , 1993, The Journal of biological chemistry.

[58]  A. Gottlieb,et al.  Human keratinocyte growth factor effects in a porcine model of epidermal wound healing , 1993, The Journal of experimental medicine.

[59]  J. Rubin,et al.  Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. , 1993, The Journal of clinical investigation.

[60]  D. Givol,et al.  Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). , 1993, Developmental biology.

[61]  N. Fusenig,et al.  Mutual induction of growth factor gene expression by epidermal-dermal cell interaction , 1993, The Journal of cell biology.

[62]  S. Werner,et al.  Targeted expression of a dominant‐negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. , 1993, The EMBO journal.

[63]  D Ron,et al.  Keratinocyte growth factor (FGF-7) stimulates migration and plasminogen activator activity of normal human keratinocytes. , 1993, The Journal of investigative dermatology.

[64]  T. Kurokawa,et al.  Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property , 1993, Molecular and cellular biology.

[65]  E. Fuchs,et al.  Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. , 1993, The EMBO journal.

[66]  J. Rubin,et al.  Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. , 1993, The Journal of biological chemistry.

[67]  B. Olwin,et al.  Identification of a cysteine-rich receptor for fibroblast growth factors , 1992, Molecular and cellular biology.

[68]  K. Matsumoto,et al.  Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[69]  S. Werner,et al.  Large induction of keratinocyte growth factor expression in the dermis during wound healing. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[70]  H. Ueno,et al.  A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. , 1992, The Journal of biological chemistry.

[71]  S. Werner,et al.  Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities , 1992, Molecular and cellular biology.

[72]  D. Podolsky,et al.  Inflammatory bowel disease (1) , 1991, The New England journal of medicine.

[73]  H. Ueno,et al.  Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor , 1991, Science.

[74]  S. Mizel,et al.  Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes. , 1991, The Journal of clinical investigation.

[75]  A. Ullrich,et al.  A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization , 1991, Molecular and cellular biology.

[76]  A. Ullrich,et al.  Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells , 1990, Molecular and cellular biology.

[77]  S. Akira,et al.  A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family. , 1990, The EMBO journal.

[78]  J. Rubin,et al.  Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. , 1989, Science.

[79]  E. Fuchs,et al.  Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[80]  D. Birnbaum,et al.  Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. , 1989, Oncogene.

[81]  J. Rubin,et al.  Purification and characterization of a newly identified growth factor specific for epithelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[82]  M J Banda,et al.  Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. , 1988, Science.

[83]  M. Goldfarb,et al.  The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors , 1988, Molecular and cellular biology.

[84]  I. Adamson,et al.  Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. , 1988, The American journal of pathology.

[85]  M. Ittmann,et al.  An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family , 1987, Cell.

[86]  J. Fiddes,et al.  Human basic fibroblast growth factor: nucleotide sequence and genomic organization. , 1986, The EMBO journal.

[87]  R. Bradshaw,et al.  Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[88]  S. O’Brien,et al.  Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. , 1986, Science.

[89]  G. Peters,et al.  Sequence, topography and protein coding potential of mouse int‐2: a putative oncogene activated by mouse mammary tumour virus. , 1986, The EMBO journal.

[90]  W. Cowan,et al.  Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[91]  R. Clark,et al.  Cutaneous tissue repair: practical implications of current knowledge. II. , 1985, Journal of the American Academy of Dermatology.

[92]  Z. Borok,et al.  Na+-K+-ATPase expression in alveolar epithelial cells: upregulation of active ion transport by KGF. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[93]  S. Rivkees Basic and Clinical Aspects , 1997 .

[94]  B. A. Gilchrest,et al.  Regulation of keratinocyte growth factor gene expression in human skin fibroblasts. , 1996, Journal of dermatological science.

[95]  M. Blumenberg,et al.  Keratinocyte growth factor and keratin gene regulation. , 1995, Journal of dermatological science.

[96]  D. Johnson,et al.  Structural and functional diversity in the FGF receptor multigene family. , 1993, Advances in cancer research.

[97]  R. Panos Cytokines and alveolar type II cells , 1993 .

[98]  D. Moscatelli,et al.  The FGF family of growth factors and oncogenes. , 1992, Advances in cancer research.

[99]  T. Fleming,et al.  Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[100]  L. Goldsmith Physiology, biochemistry, and molecular biology of the skin , 1991 .

[101]  R. Sartor Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease , 1991, Immunologic research.

[102]  H. Shepard,et al.  Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α , 1987, Nature.