Metastasis of adenocarcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature.

SUMMARY Polyps are the most common benign lesions in the endometrium. Metastasis to the endometrial polyp from a distant primary tumor is rare. Breast carcinoma is the most frequent extragenital cancer that metastasizes to the endometrial polyp. We report the case of a 63-year-old with metastatic gall bladder adenocarcinoma involving endometrial polyps detected by endometrial curetting. It was the first sign of her metastatic disease. After this diagnosis, bone metastases were detected during radiologic screening. Gastrointestinal tumor metastasis to an endometrial polyp is a very rare event, but if a patient with a known primary extragenital tumor has abnormal vaginal bleeding, the possibility of metastasis should be included in the differential diagnosis.

[1]  W. Lau,et al.  Gallbladder cancer--a comprehensive review. , 2008, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[2]  J. Donohue,et al.  Diagnosis and Surgical Management of Gallbladder Cancer: A Review , 2007, Journal of Gastrointestinal Surgery.

[3]  L. Elavathil,et al.  Metastatic breast lobular carcinoma to tamoxifen-associated endometrial polyp: case report and literature review. , 2005, Annals of diagnostic pathology.

[4]  M. Deavers,et al.  Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma. , 2005, Gynecologic oncology.

[5]  E. Yavuz,et al.  Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp. , 2005, Gynecologic oncology.

[6]  C. Scopa,et al.  Metastases of breast carcinoma to the uterus. Report of two cases, one harboring a primary endometrioid carcinoma, with review of the literature. , 2005, Gynecologic oncology.

[7]  J. Ortiz-Rey,et al.  Metastatic Lobular Breast Carcinoma to an Endometrial Polyp Diagnosed by Hysteroscopic Biopsy , 2003, Obstetrics and gynecology.

[8]  T. Rollason Blaustein’s Pathology of the Female Genital Tract , 2003, Springer New York.

[9]  Joseph P Houghton,et al.  Metastatic Breast Lobular Carcinoma Involving Tamoxifen-Associated Endometrial Polyps: Report of Two Cases and Review of Tamoxifen-Associated Polypoid Uterine Lesions , 2003, Modern Pathology.

[10]  A. Taylor,et al.  Metastatic carcinoma of breast diagnosed following hysteroscopy and endometrial biopsy , 2002, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[11]  D. Schust,et al.  Primary adenocarcinoma of the gallbladder presenting as primary gynecologic malignancy: A report of two cases , 1994, Obstetrics and gynecology.

[12]  Moore Dh,et al.  Primary adenocarcinoma of the gallbladder presenting as primary gynecologic malignancy: a report of two cases. , 1994 .

[13]  M. Sherman,et al.  Uterine Serous Carcinoma A Morphologically Diverse Neoplasm With Unifying Clinicopathologic Features , 1992, The American journal of surgical pathology.

[14]  V. Livolsi,et al.  Postmenopausal Bleeding From Unusual Endometrial Polyps in Women on Chronic Tamoxifen Therapy , 1992, Obstetrics and gynecology.

[15]  J. Sullivan,et al.  Breast carcinoma metastatic to endometrial polyp. , 1990, Gynecologic oncology.

[16]  E. Silva,et al.  Serous carcinoma in endometrial polyps. , 1990, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[17]  F. Borchard,et al.  Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature , 1985, Journal of surgical oncology.

[18]  M. Mazur,et al.  Metastases to the female genital tract: Analysis of 325 cases , 1984, Cancer.

[19]  W. R. Hart,et al.  Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases , 1982, Cancer.

[20]  A. Ferenczy,et al.  Homologous mixed Müllerian tumors (carcinosarcomal) confined to endometrial polyps. , 1975, American journal of obstetrics and gynecology.

[21]  H. Fox,et al.  A KRUKENBERG TUMOUR OF THE UTERINE CERVIX , 1967, The Journal of obstetrics and gynaecology of the British Commonwealth.

[22]  F. Vellios,et al.  Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. , 1963, American journal of clinical pathology.

[23]  F. Askin,et al.  Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. , 1990, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[24]  R. Demopoulos Benign Diseases of the Endometrium , 1977 .