Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation
暂无分享,去创建一个
S. Meuth | T. Budde | G. Seebohm | T. Ruck | T. Baukrowitz | S. Bittner | B. Wünsch | Petra Hundehege | T. Müntefering | S. Bock | A. Herrmann | M. Kuzikov | P. Gribbon | S. Albrecht | Niklas Huntemann | Christopher Nelke | Christina B. Schroeter | Marcus Schewe | Lucas Spohler | L. C. Neelsen | Lea C. Neelsen
[1] M. Xie,et al. The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood–Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice , 2022, Molecular Neurobiology.
[2] S. Meuth,et al. Mini-Review: Two Brothers in Crime – The Interplay of TRESK and TREK in Human Diseases , 2021, Neuroscience Letters.
[3] U. Dannlowski,et al. K2P18.1 translates T cell receptor signals into thymic regulatory T cell development , 2021, Cell research.
[4] W. González,et al. Molecular Pharmacology of K2P Potassium Channels. , 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
[5] R. Olcese,et al. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury , 2020, Scientific Reports.
[6] J. Rosenberg,et al. K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions , 2020, Science Advances.
[7] A. Mathie,et al. Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. , 2019, Biochemical and biophysical research communications.
[8] M. Xie,et al. Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice , 2019, Journal of Neuroinflammation.
[9] C. Heurteaux,et al. Role of TREK-1 in Health and Disease, Focus on the Central Nervous System , 2019, Front. Pharmacol..
[10] B. L. de Groot,et al. A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels , 2019, Science.
[11] A. Renslo,et al. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels , 2018, ACS chemical neuroscience.
[12] D. Rivière,et al. eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data , 2018, bioRxiv.
[13] H. Pape,et al. Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels , 2017, Brain Structure and Function.
[14] D. Minor,et al. K2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site , 2017, Nature.
[15] Matthew T. Dickerson,et al. Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. , 2017, ACS chemical neuroscience.
[16] M. Xie,et al. Deficiency of TREK‐1 potassium channel exacerbates secondary injury following spinal cord injury in mice , 2017, Journal of neurochemistry.
[17] H. Wiendl,et al. The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells. , 2016, American journal of physiology. Cell physiology.
[18] B. L. de Groot,et al. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels , 2016, Cell.
[19] H. Pape,et al. Differential phospholipase C‐dependent modulation of TASK and TREK two‐pore domain K+ channels in rat thalamocortical relay neurons , 2015, The Journal of physiology.
[20] H. Pape,et al. The role of two-pore-domain background K+ (K2P) channels in the thalamus , 2015, Pflügers Archiv - European Journal of Physiology.
[21] N. Franks,et al. Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels , 2014, Pflügers Archiv - European Journal of Physiology.
[22] S. Meuth,et al. TREK-King the Blood–Brain-Barrier , 2014, Journal of Neuroimmune Pharmacology.
[23] H. Pape,et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS , 2013, Nature Medicine.
[24] A. Renslo,et al. A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels , 2013, ACS chemical biology.
[25] H. Pape,et al. Ca2+-dependent large conductance K+ currents in thalamocortical relay neurons of different rat strains , 2013, Pflügers Archiv - European Journal of Physiology.
[26] Zhaobing Gao,et al. Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants , 2012, PloS one.
[27] R. Peyronnet,et al. A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases , 2011, PloS one.
[28] H. Pape,et al. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons , 2011, Pflügers Archiv - European Journal of Physiology.
[29] E. Chevet,et al. Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design , 2010, PLoS biology.
[30] Ryan Bogdan,et al. Variation in TREK1 gene linked to depression‐resistant phenotype is associated with potentiated neural responses to rewards in humans , 2009, Human brain mapping.
[31] P. Moorjani,et al. Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR*D Study , 2008, Neuropsychopharmacology.
[32] G. Debonnel,et al. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype , 2006, Nature Neuroscience.
[33] M. Lazdunski,et al. Cross‐talk between the mechano‐gated K2P channel TREK‐1 and the actin cytoskeleton , 2005, EMBO reports.
[34] T. Neelands,et al. BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties , 2005, Journal of Pharmacology and Experimental Therapeutics.
[35] S. Dworetzky,et al. A Thallium-Sensitive, Fluorescence-Based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian Cells , 2004, Journal of biomolecular screening.
[36] M. Lazdunski,et al. TREK‐1, a K+ channel involved in neuroprotection and general anesthesia , 2004, The EMBO journal.
[37] B. Robertson,et al. A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[38] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.