PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
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M. Moriguchi | T. Okanoue | Yusuke Ito | J. Kamon | H. Fujii | Yuya Seko | K. Yamaguchi | Y. Itoh | A. Umemura | Seita Kataoka | Keiichiroh Okuda | K. Yasui | H. Ishiba | N. Tochiki | Shinya Okishio | Kota Yano | A. Takahashi | Yu Liu | Daiki Takahashi
[1] M. Karin,et al. An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis , 2020, Science.
[2] A. Duseja,et al. Peroxisome Proliferator-Activated Receptors and Their Agonists in Nonalcoholic Fatty Liver Disease. , 2019, Journal of clinical and experimental hepatology.
[3] D. Schuppan,et al. Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer , 2019, American journal of physiology. Gastrointestinal and liver physiology.
[4] S. Sabbioni,et al. Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma , 2019, Oncogene.
[5] W. Seeger,et al. Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis , 2019, Nature Communications.
[6] D. Détaille,et al. Role of Mitochondria in the Mechanism(s) of Action of Metformin , 2019, Front. Endocrinol..
[7] Vahid Mohammadkarimi,et al. Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial , 2019, European journal of gastroenterology & hepatology.
[8] M. Larocca,et al. Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration , 2019, Scientific Reports.
[9] J. Gromada,et al. Preemptive Activation of the Integrated Stress Response Protects Mice From Diet‐Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction , 2018, Hepatology.
[10] B. Aronow,et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. , 2018, JCI insight.
[11] M. Yoneda,et al. Current and future pharmacological therapies for NAFLD/NASH , 2017, Journal of Gastroenterology.
[12] Hai Yuan,et al. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms , 2017, Oncotarget.
[13] G. Steinberg,et al. AMPK as a Therapeutic Target for Treating Metabolic Diseases , 2017, Trends in Endocrinology & Metabolism.
[14] R. Pais,et al. Fatty liver and renal function impairment - Time for awareness? , 2017, Journal of hepatology.
[15] Philippe Lehert,et al. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. , 2016, Gastroenterology.
[16] W. Wahli,et al. Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD , 2016, Gut.
[17] M. Bhat,et al. AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells , 2016, Cell Death and Disease.
[18] J. Boyer,et al. Fibrates and cholestasis , 2015, Hepatology.
[19] E. van Marck,et al. PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. , 2015, Journal of hepatology.
[20] Vanessa Souza-Mello,et al. Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease. , 2015, World journal of hepatology.
[21] Philippe Lefebvre,et al. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. , 2015, Journal of hepatology.
[22] E. Fontaine,et al. Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model , 2014, Diabetes.
[23] B. Viollet,et al. Metformin: from mechanisms of action to therapies. , 2014, Cell metabolism.
[24] K. Petersen,et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes , 2014, Nature.
[25] A. Gastaldelli,et al. HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH , 2014, PloS one.
[26] Shih-Yi Lin,et al. Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. , 2014, Endocrinology.
[27] D. Rutkowski,et al. The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis , 2013, PLoS genetics.
[28] E. Mercken,et al. Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.
[29] K. Ichihara,et al. Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR. , 2013, Journal of pharmacological sciences.
[30] Hao Wang,et al. Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress , 2013, Diabetes.
[31] H. Tilg,et al. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis , 2010, Hepatology.
[32] Michael Müller,et al. Peroxisome Proliferator-Activated Receptor Alpha Target Genes , 2010, PPAR research.
[33] J. Flier,et al. Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State , 2010, Diabetes.
[34] M. Martínez-Chantar,et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. , 2010, Gastroenterology.
[35] B. Neuschwander‐Tetri,et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. , 2010, The New England journal of medicine.
[36] C. C. Brackett. Clarifying metformin's role and risks in liver dysfunction. , 2010, Journal of the American Pharmacists Association : JAPhA.
[37] J. Suttles,et al. Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype1 , 2008, The Journal of Immunology.
[38] M. Katze,et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.
[39] H. Tilg,et al. Inflammatory Mechanisms in the Regulation of Insulin Resistance , 2008, Molecular medicine.
[40] B. Göke,et al. The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes , 2007, Diabetes & vascular disease research.
[41] S. Kliewer,et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.
[42] S. McCall,et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.
[43] S. Kahn,et al. Mechanisms linking obesity to insulin resistance and type 2 diabetes , 2006, Nature.
[44] G. Targher,et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. , 2005, Diabetes.
[45] G. Gibbons,et al. A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. , 2005, The Biochemical journal.
[46] Roger A. Davis,et al. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ , 2004 .
[47] E. Bruckert,et al. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women , 2004, International Journal of Obesity.
[48] Kohjiro Ueki,et al. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[49] Roger A. Davis,et al. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. , 2004, The Journal of clinical investigation.
[50] B. Neuschwander‐Tetri,et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.
[51] B. Spiegelman,et al. IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.
[52] J. Ludwig,et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. , 1980, Mayo Clinic proceedings.