DNA ploidy compared with human papilloma virus testing (Hybrid Capture II) and conventional cervical cytology as a primary screening test for cervical high‐grade lesions and cancer in 1555 patients with biopsy confirmation

Because 80% of cervical cancers arise in low‐resource settings, many inexpensive strategies are being tested. In that spirit, the authors are testing large‐scale genomic or DNA ploidy measurements as an inexpensive and semiautomated strategy.

[1]  G. Haroske,et al.  Part I: Basic Considerations and Recommendations for Preparation, Measurement and Interpretation , 1998, Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology.

[2]  R. Bollmann,et al.  Aberrant, highly hyperdiploid cells in human papillomavirus‐positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix , 2005, Cancer.

[3]  B Palcic,et al.  Nuclear texture measurements in image cytometry. , 1995, Pathologica.

[4]  A. Böcking,et al.  Diagnostic and prognostic use of DNA image cytometry in cervical squamous intraepithelial lesions and invasive carcinoma , 2003, Zhonghua bing li xue za zhi = Chinese journal of pathology.

[5]  Thin-layer cervical cytology: a new meta-analysis , 2006, The Lancet.

[6]  Thomas C Wright,et al.  2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities. , 2002, Journal of lower genital tract disease.

[7]  J. L. Benedet,et al.  Organisation and results of the cervical cytology screening programme in British Columbia, 1955-85 , 1988, British medical journal.

[8]  Branko Palcic,et al.  Detection of Cervical Cancer and High Grade Neoplastic Lesions by a Combination of Liquid‐Based Sampling Preparation and DNA Measurements Using Automated Image Cytometry , 2005, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[9]  L. Belghiti,et al.  Prognostic factors in breast cancer , 2002 .

[10]  S. Edge,et al.  Prognostic factors in breast cancer , 2005 .

[11]  J. L. Benedet,et al.  Cervical intraepithelial neoplasia in British Columbia: a comprehensive program for detection, diagnosis, and treatment. , 1981, Gynecologic oncology.

[12]  L. Irwig,et al.  Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review , 2006, The Lancet.

[13]  J. Sudbø,et al.  Retracted: The evolution of predictive oncology and molecular‐based therapy for oral cancer prevention , 2005, International journal of cancer.

[14]  R. Richards-Kortum,et al.  Optical technologies for cervical neoplasia: update of an NCI program project grant. , 2005, Clinical advances in hematology & oncology : H&O.

[15]  J. Dillner,et al.  Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence. , 2005, Gynecologic oncology.

[16]  B Palcic,et al.  The use of an automated image cytometer for screening and quantitative assessment of cervical lesions in the British Columbia Cervical Smear Screening Programme , 1997, Cytopathology : official journal of the British Society for Clinical Cytology.

[17]  D. M. Parkin,et al.  Corrigendum to “Cancer burden in the year 2000. The global picture” [European Journal of Cancer,37(Suppl. 8) (2001) S4–S66] , 2003 .

[18]  J. Sudbø,et al.  The influence of resection and aneuploidy on mortality in oral leukoplakia. , 2004, The New England journal of medicine.

[19]  Calum MacAulay,et al.  Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issues. , 2005, Gynecologic oncology.

[20]  L Irwig,et al.  Meta-analysis of Pap test accuracy. , 1995, American journal of epidemiology.

[21]  A. Shaw.  Human papillomavirus vaccines in development: if they're successful in clinical trials, how will they be implemented? , 2005, Gynecologic oncology.

[22]  Thomas C Wright,et al.  Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities , 2002 .

[23]  J. Sudbø,et al.  Retracted: Comparison of histological grading and large‐scale genomic status (DNA ploidy) as prognostic tools in oral dysplasia , 2001, The Journal of pathology.

[24]  Calum MacAulay,et al.  Quality Assurance System Using Statistical Process Control: An Implementation for Image Cytometry , 2004, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[25]  Eric Lucas,et al.  Initial results from a randomized trial of cervical visual screening in rural south India , 2004, International journal of cancer.

[26]  F. Bray,et al.  Cancer burden in the year 2000. The global picture. , 2001, European journal of cancer.

[27]  G. Haroske,et al.  Part II: Specific Recommendations for Quality Assurance , 1998, Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology.

[28]  G. Papanicolaou,et al.  The diagnostic value of vaginal smears in carcinoma of the uterus. 1941. , 1941, Archives of pathology & laboratory medicine.

[29]  Martial Guillaud,et al.  Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues , 2004, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[30]  R. Bollmann,et al.  Human papillomavirus typing and DNA ploidy determination of squamous intraepithelial lesions in liquid‐based cytologic samples , 2002, Cancer.

[31]  L Gaffikin,et al.  A critical assessment of screening methods for cervical neoplasia , 2005, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[32]  M. Follen,et al.  Surrogate endpoint biomarkers and their modulation in cervical chemoprevention trials , 2001, Cancer.

[33]  Papanicolaou Gn,et al.  The diagnostic value of vaginal smears in carcinoma of the uterus. 1941. , 1997 .

[34]  M. Schiffman,et al.  Adding a test for human papillomavirus DNA to cervical-cancer screening. , 2003, The New England journal of medicine.

[35]  C. Clavel,et al.  DNA image cytometry and human papillomavirus (HPV) detection help to select smears at high risk of high‐grade cervical lesions , 2001, The Journal of pathology.

[36]  Martial Guillaud,et al.  Exploratory analysis of quantitative histopathology of cervical intraepithelial neoplasia: Objectivity, reproducibility, malignancy‐associated changes, and human papillomavirus , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[37]  K Vajda,et al.  [Prognostic factors in breast cancer]. , 1998, Orvosi hetilap.

[38]  C. MacAulay,et al.  Oncometrics Imaging Corporation and Xillix Technologies Corporation. Use of the Cyto-Savant in quantitative cytology. , 1996, Acta Cytologica.