Preclinical evaluation of wound contraction property of ocimum sanctum with and without supportive treatment of silver sulfadiazine in Rabbits

Burns remain a major public health problem all over the world, especially in developing countries. Pseudomonas aeruginosa is a major cause of infection and a contributing factor in the death of patients with burns. So, there is a growing need to develop drugs which will prevent infections and complications more effectively than the presently used drugs. Ocimum sanctum L. (Holy basil in English and Tulsi in Hindi) has been shown to have antioxidant properties, which may be responsible and favorable for faster wound healing. The present study was carried out to evaluate the wound contraction property of Ocimum sanctum in thermal burns with and without supportive treatment of Ointment Silver Sulfadiazine. After the end of treatment at 28th day, group treated with Ointment Silver sulfadiazine + Ocimum sanctum showed 93.17±4.34 percent wound contraction (p-value0.000, p<0.05 Significant) which was the maximum among all groups.