Optimised care of elderly patients with acute coronary syndrome

Advancing life expectancy is being paralleled by a continuous increase of elderly patients with several acute cardiovascular conditions, including acute coronary syndrome (ACS). Paradoxically, despite the rising prevalence of elderly patients, older age has been a typical exclusion criterion of randomised controlled trials assessing the efficacy and safety of therapies in these patients. Therefore, the evidence to inform optimal care delivery to elderly patients with ACS is limited. Challenges in the clinical management of older patients with ACS include accurate clinical assessment, optimal selection of revascularisation and antithrombotic strategies, and decisions on the appropriate level of care once the expected patient prognosis and quality of life has been determined. In this review we provide an overview of these challenges, including practical suggestions for their management. Unless otherwise specified, by ‘elderly’ we mean individuals 75 years of age or older.

[1]  Deepak L. Bhatt,et al.  Practical considerations for cangrelor use in patients with acute coronary syndromes , 2019, European heart journal. Acute cardiovascular care.

[2]  Marco Valgimigli,et al.  2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). , 2018, European heart journal.

[3]  P. Kolh,et al.  2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. , 2018, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[4]  P. Kolh,et al.  [2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS.] , 2018, Kardiologia polska.

[5]  J. Zamorano,et al.  Frailty is an independent prognostic marker in elderly patients with myocardial infarction , 2017, Clinical cardiology.

[6]  James O. Mudd,et al.  The prevalence of frailty in heart failure: A systematic review and meta-analysis. , 2017, International journal of cardiology.

[7]  Deepak L. Bhatt,et al.  Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials , 2017, The Lancet.

[8]  H. Bueno,et al.  Editor’s Choice-The organization of chest pain units: Position statement of the Acute Cardiovascular Care Association , 2017, European heart journal. Acute cardiovascular care.

[9]  P. Dehghani,et al.  Transradial approach for coronary angiography and intervention in the elderly: A meta-analysis of 777,841 patients. , 2017, International journal of cardiology.

[10]  S. de Servi,et al.  A comparison of reduced-dose prasugrel and standard-dose clopidogrel in elderly patients with acute coronary syndromes undergoing early percutaneous revascularization: Design and rationale of the randomized Elderly-ACS 2 study. , 2016, American heart journal.

[11]  S. Windecker,et al.  Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial , 2016, British Medical Journal.

[12]  C. Held,et al.  Effect of age on efficacy and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial. , 2016, American heart journal.

[13]  J. Afilalo,et al.  Implications of Frailty in Elderly Patients With Electrophysiological Conditions. , 2016, JACC. Clinical electrophysiology.

[14]  Barbara Resnick,et al.  Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society. , 2016, Journal of the American College of Cardiology.

[15]  J. Spertus,et al.  Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention. , 2016, JAMA.

[16]  B. Bendz,et al.  Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial , 2016, The Lancet.

[17]  B. Guidet,et al.  Are elderly patients' opinions sought before admission to an intensive care unit? Results of the ICE-CUB study. , 2016, Age and ageing.

[18]  Baris Gencer,et al.  ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation , 2011 .

[19]  N. Brunetti,et al.  Pre-hospital management of patients with chest pain and/or dyspnoea of cardiac origin. A position paper of the Acute Cardiovascular Care Association (ACCA) of the ESC. , 2020, European heart journal. Acute cardiovascular care.

[20]  J. Jukema,et al.  Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome: Optimization of antiplatelet treatment in patients 70 years and older--rationale and design of the POPular AGE study. , 2015, American heart journal.

[21]  T. Therneau,et al.  Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity. , 2014, Mayo Clinic proceedings.

[22]  Mandeep Singh,et al.  Importance of frailty in patients with cardiovascular disease. , 2014, European heart journal.

[23]  S. Servi,et al.  Early invasive versus selectively invasive strategy in patients with non‐ST‐segment elevation acute coronary syndrome: Impact of age , 2014, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[24]  Daniel E Forman,et al.  Frailty assessment in the cardiovascular care of older adults. , 2014, Journal of the American College of Cardiology.

[25]  Jeroen J. Bax,et al.  2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. , 2013, European heart journal.

[26]  S. de Servi,et al.  Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial. , 2012, JACC. Cardiovascular interventions.

[27]  S. Pocock,et al.  Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials , 2011, Heart.

[28]  G. Mitchell Utility of Left Bundle Branch Block as a Diagnostic Criterion for Acute Myocardial Infarction , 2011 .

[29]  J. Ornato,et al.  Outcomes in patients with chronicity of left bundle-branch block with possible acute myocardial infarction. , 2011, American heart journal.

[30]  Kenneth Rockwood,et al.  Frailty defined by deficit accumulation and geriatric medicine defined by frailty. , 2011, Clinics in geriatric medicine.

[31]  Christopher P Cannon,et al.  Acute coronary syndromes: diagnosis and management, part I. , 2009, Mayo Clinic proceedings.

[32]  I. McDowell,et al.  A global clinical measure of fitness and frailty in elderly people , 2005, Canadian Medical Association Journal.

[33]  C. Cassel,et al.  Treatment choices at the end of life: a comparison of decisions by older patients and their physician-selected proxies. , 1989, The Gerontologist.

[34]  E. Cook,et al.  Comparison of clinical presentation of acute myocardial infarction in patients older than 65 years of age to younger patients: the Multicenter Chest Pain Study experience. , 1989, The American journal of cardiology.