The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment.

OBJECTIVE This study investigated light emitting diode (LED) treatment for patients with melasma on darker skin types. BACKGROUND Melasma is a common disfiguring skin condition in women which is difficult to treat and is refractory. The cause of melasma remains unclear. METHODS In this study, 60 female participants aged between 25 and 60 years, who presented with melasma, were enrolled (n = 39.85). They were purposely assigned to two groups according to their skin types. Both groups received a total of 36 LED light treatments over a period of 9 months. RESULTS Both subjective and objective results indicated a significant improvement of melasma. Statistical analyses revealed significant improvements in both groups. CONCLUSIONS The results of this study suggest that LED is effective in managing melasma. These results will provide a basis for future therapeutic use of phototherapy to improve melasma.

[1]  A. Alexis,et al.  Melasma , 2019, Evidence-Based Procedural Dermatology.

[2]  D. Goldberg Editorial , 2018, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[3]  Pu Chen,et al.  Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[4]  A. Ehsani,et al.  Tranexamic acid in treatment of melasma: A comprehensive review of clinical studies , 2017, Dermatologic therapy.

[5]  H. Miot,et al.  African ancestry is associated with facial melasma in women: a cross-sectional study , 2017, BMC Medical Genetics.

[6]  S. Sethi,et al.  Updates in the understanding and treatments of skin & hair disorders in women of color☆☆☆★ , 2017, International journal of women's dermatology.

[7]  W. Valdar,et al.  Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations , 2016, Clinical Epigenetics.

[8]  K. Muralidhar,et al.  A clinical study of melasma and assessment of Dermatology Life Quality Index at a tertiary health care center in South India , 2016 .

[9]  Kyoung-Chan Park,et al.  Heterogeneous Pathology of Melasma and Its Clinical Implications , 2016, International journal of molecular sciences.

[10]  Roland Eils,et al.  Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms. , 2016, The Journal of allergy and clinical immunology.

[11]  I. Haq,et al.  Proposing Melasma Severity Index: A New, More Practical, Office-based Scoring System for Assessing the Severity of Melasma , 2016, Indian journal of dermatology.

[12]  J. Betkerur,et al.  Clinico-epidemiological Study and Quality of Life Assessment in Melasma , 2015, Indian journal of dermatology.

[13]  J. Maegawa,et al.  Influence of the frequency of laser toning for melasma on occurrence of leukoderma and its early detection by ultraviolet imaging , 2015, Lasers in surgery and medicine.

[14]  S. Garg,et al.  Chapter-13 Melasma and Quality of Life , 2015 .

[15]  E. Jourdan,et al.  Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. , 2015, Journal of the American Academy of Dermatology.

[16]  H. Miot,et al.  Risk factors for facial melasma in women: a case–control study , 2014, The British journal of dermatology.

[17]  L. Azulay-Abulafia,et al.  Epidemiology of melasma in Brazilian patients: a multicenter study , 2014, International journal of dermatology.

[18]  G. Kadhe,et al.  A Cross-Sectional, Multicentric Clinico-Epidemiological Study of Melasma in India , 2014, Dermatology and Therapy.

[19]  O. Dadzie,et al.  Chemical peeling in ethnic skin: an update , 2013, The British journal of dermatology.

[20]  J. Na,et al.  Effect of tranexamic acid on melasma: a clinical trial with histological evaluation , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[21]  B. N. Srinivas,et al.  A Clinical Study of Melasma and a Comparison of the Therapeutic Effect of Certain Currently Available Topical Modalities for its Treatment , 2013, Indian journal of dermatology.

[22]  H. Miot,et al.  Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women , 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

[23]  M. Timalsina,et al.  Q-Switched Neodymium-Doped Yttrium Aluminum Garnet laser therapy for pigmented skin lesions: efficacy and safety. , 2013, Kathmandu University medical journal.

[24]  P. Suchonwanit,et al.  Melasma in men , 2012, Journal of cosmetic dermatology.

[25]  Yi Sun,et al.  Treatment of Melasma With Oral Administration of Tranexamic Acid , 2012, Aesthetic Plastic Surgery.

[26]  R. Halder,et al.  Why are there so few effective treatments for pigmentary disorders of the skin , 2012 .

[27]  R. Wanitphakdeedecha,et al.  Measuring melasma patients' quality of life using willingness to pay and time trade-off methods in thai population , 2011, BMC dermatology.

[28]  P. Bahadoran,et al.  Melasma treatment with pulsed-dye laser and triple combination cream: a prospective, randomized, single-blind, split-face study. , 2011, Archives of dermatology.

[29]  S. Rathi,et al.  MELASMA: A CLINICO-EPIDEMIOLOGICAL STUDY OF 312 CASES , 2011, Indian journal of dermatology.

[30]  H. Tagami,et al.  Instrumental analysis of the pattern of improvement and that of recurrence of melasma in Thai females treated with Kligman–Willis triple combination therapy: confirmation by using its two different formulae , 2011, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[31]  Vaneeta M. Sheth,et al.  Melasma: a comprehensive update: part II. , 2011, Journal of the American Academy of Dermatology.

[32]  E. Berardesca,et al.  Characterization and evaluation of pigment distribution and response to therapy in melasma using in vivo reflectance confocal microscopy: a preliminary study , 2010, Journal of the European Academy of Dermatology and Venereology : JEADV.

[33]  N. Chan,et al.  Supply China Bags Women Handbags Mix OEM/ODM Quotes - Miracle , 2010 .

[34]  N. Kollias,et al.  Impact of long-wavelength UVA and visible light on melanocompetent skin. , 2010, The Journal of investigative dermatology.

[35]  Lam Sm Considerations in non-Caucasian facial plastic surgery. Preface. , 2010 .

[36]  H. Drexler,et al.  An overview of skin scores used for quantifying hand eczema: a critical update according to the criteria of evidence‐based medicine , 2010, The British journal of dermatology.

[37]  P. Bahadoran,et al.  In vivo reflectance confocal microscopy detects pigmentary changes in melasma at a cellular level resolution , 2009, Experimental dermatology.

[38]  Henry W. Lim,et al.  Effects of Visible Light on the Skin † , 2008, Photochemistry and photobiology.

[39]  Ki-Ho Park,et al.  A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. , 2007, Journal of photochemistry and photobiology. B, Biology.

[40]  Francisco Solano,et al.  Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. , 2006, Pigment cell research.

[41]  Keyvan Nouri,et al.  The treatment of melasma: a review of clinical trials. , 2006, Journal of the American Academy of Dermatology.

[42]  M. Picardo,et al.  Treatment of melasma. , 2006, Journal of the American Academy of Dermatology.

[43]  Xiao-ru Wang,et al.  Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. , 2005, Journal of agricultural and food chemistry.

[44]  R. Geronemus,et al.  Clinical trial of a novel non‐thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results , 2005, Lasers in surgery and medicine.

[45]  B A Russell,et al.  A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation , 2005, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[46]  B. Moncada,et al.  A double‐blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma , 2004, International journal of dermatology.

[47]  W. Roberts,et al.  Chemical peeling in ethnic/dark skin , 2004, Dermatologic therapy.

[48]  B. Rao,et al.  Melasma: A Review , 2004, Journal of cutaneous medicine and surgery.

[49]  A. Pandya,et al.  Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma , 2003, International journal of dermatology.

[50]  Alessandra Haddad,et al.  A clinical, prospective, randomized, double‐blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma , 2003, International journal of dermatology.

[51]  P. Papageorgiou,et al.  Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris , 2000, The British journal of dermatology.

[52]  R. Dash,et al.  Melasma in Men: A Hormonal Profile , 2000, The Journal of dermatology.

[53]  C R Taylor,et al.  Wood’s light in dermatology , 1999, International journal of dermatology.

[54]  Frcpi,et al.  Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. , 1999 .

[55]  P. Grimes The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. , 1999, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[56]  C. Antoniou,et al.  Melasma. Classification and treatment , 1995 .

[57]  M. Mihm,et al.  Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study. , 1981, Journal of the American Academy of Dermatology.