T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.

[1]  C. Abraham,et al.  Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens , 2019, Mucosal Immunology.

[2]  Ricardo J. Miragaia,et al.  Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation , 2017, Cell.

[3]  C. Abraham,et al.  IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome , 2018, The Journal of Immunology.

[4]  J. van Grevenynghe,et al.  IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection. , 2018, Cell reports.

[5]  Baohong Zhang,et al.  B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation , 2018, Front. Immunol..

[6]  F. Liu,et al.  Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection , 2017, Nature Communications.

[7]  S. Wenzel,et al.  IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice. , 2017, JCI insight.

[8]  F. Andris,et al.  The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells , 2017, Front. Immunol..

[9]  V. Paradis,et al.  IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. , 2016, JCI insight.

[10]  Todd M. Allen,et al.  The epigenetic landscape of T cell exhaustion , 2016, Science.

[11]  I. Udalova,et al.  A critical role for IRF5 in regulating allergic airway inflammation , 2016, Mucosal Immunology.

[12]  C. Abraham,et al.  IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. , 2016, Cell reports.

[13]  Haidong Xu,et al.  Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice , 2016, Inflammation.

[14]  M. Altfeld,et al.  Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women , 2015, The Journal of Immunology.

[15]  M. Feldmann,et al.  IRF5 controls both acute and chronic inflammation , 2015, Proceedings of the National Academy of Sciences.

[16]  C. Ishikawa,et al.  Constitutive expression of IRF-5 in HTLV-1-infected T cells. , 2015, International journal of oncology.

[17]  K. Clément,et al.  Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity , 2015, Nature Medicine.

[18]  Yuanyuan Wu,et al.  IRF5 Deficiency Ameliorates Lupus but Promotes Atherosclerosis and Metabolic Dysfunction in a Mouse Model of Lupus-Associated Atherosclerosis , 2015, The Journal of Immunology.

[19]  P. Cohen,et al.  Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells , 2014, Proceedings of the National Academy of Sciences.

[20]  Zhijian J. Chen,et al.  IKKβ is an IRF5 kinase that instigates inflammation , 2014, Proceedings of the National Academy of Sciences.

[21]  J. Ragoussis,et al.  IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages , 2014, Cell reports.

[22]  F. Lasitschka,et al.  Counter-regulation of T cell effector function by differentially activated p38 , 2014, The Journal of experimental medicine.

[23]  J. Perfect,et al.  T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation , 2014, Proceedings of the National Academy of Sciences.

[24]  Graham M Lord,et al.  Genome-Wide Regulatory Analysis Reveals That T-bet Controls Th17 Lineage Differentiation through Direct Suppression of IRF4 , 2013, The Journal of Immunology.

[25]  Daniel G. Anderson,et al.  In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. , 2013, Journal of the American College of Cardiology.

[26]  C. Abraham,et al.  NF-κB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms , 2013, Molecular and Cellular Biology.

[27]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[28]  Lisong Yang,et al.  Monocytes from Irf5−/− Mice Have an Intrinsic Defect in Their Response to Pristane-Induced Lupus , 2012, The Journal of Immunology.

[29]  Lisong Yang,et al.  Irf5‐deficient mice are protected from pristane‐induced lupus via increased Th2 cytokines and altered IgG class switching , 2012, European journal of immunology.

[30]  C. Abraham,et al.  IRF5 Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells , 2012, The Journal of Immunology.

[31]  R. Maul,et al.  Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response , 2012, Genes and Immunity.

[32]  L. Moldawer,et al.  Pleiotropic IFN-Dependent and -Independent Effects of IRF5 on the Pathogenesis of Experimental Lupus , 2012, The Journal of Immunology.

[33]  H. Lockstone,et al.  IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses , 2011, Nature Immunology.

[34]  T. Mak,et al.  Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice. , 2011, Arthritis and rheumatism.

[35]  P. Pitha,et al.  Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection , 2011, PLoS pathogens.

[36]  A. Keegan,et al.  Transcriptional Control of Rapid Recall by Memory CD4 T Cells , 2010, The Journal of Immunology.

[37]  K. Fitzgerald,et al.  Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination , 2008, Molecular and Cellular Biology.

[38]  Marta E Alarcón-Riquelme,et al.  A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus , 2006, Nature Genetics.

[39]  Katherine E. M. Hoops,et al.  Two Discrete Promoters Regulate the Alternatively Spliced Human Interferon Regulatory Factor-5 Isoforms , 2005, Journal of Biological Chemistry.

[40]  Tak W. Mak,et al.  Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors , 2005, Nature.

[41]  P. Pitha,et al.  Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes , 2002, Molecular and Cellular Biology.

[42]  Chyung-Ru Wang,et al.  Helper T cell differentiation is controlled by the cell cycle. , 1998, Immunity.

[43]  I. Udalova,et al.  Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease. , 2016, Translational research : the journal of laboratory and clinical medicine.

[44]  洋英 大西,et al.  膵疾患におけるInterferon Regulatory Factorの役割 , 2014 .

[45]  M. Kubo,et al.  The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response. , 2002, International immunology.