Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives

Aims/HypothesisInsulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients.MethodsAdiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes.ResultsIn the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (p < 0.001). There was no correlation with antibody status or later development of diabetes. In 24 Ab+ relatives sampled fasted, adiponectin levels correlated significantly with homeostasis model assessment of insulin sensitivity (p = 0.006). In Ab+ relatives (n = 211), adiponectin levels could not predict type 1 diabetes nor complement risk assessment based on islet antibodies, HLA-DQ genotype and pancreatic hormones in Cox regression analysis.Conclusions/InterpretationAdiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.

[1]  C. Mathieu,et al.  Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes , 2005, Diabetologia.

[2]  A. Gressner,et al.  Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. , 2004, Clinical chemistry.

[3]  T. Wilkin The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes , 2001, Diabetologia.

[4]  W. Hanif,et al.  Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males , 2005, Diabetologia.

[5]  Rui Mao,et al.  Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes , 2005, Diabetologia.

[6]  John A Wagner,et al.  Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity* , 2004, Journal of Biological Chemistry.

[7]  L. Harrison,et al.  Insulin resistance is a risk factor for progression to Type 1 diabetes , 2004, Diabetologia.

[8]  J. Ludvigsson,et al.  A high weight gain early in life is associated with an increased risk of Type 1 (insulin-dependent) diabetes mellitus , 2004, Diabetologia.

[9]  R. Paschke,et al.  Regulation of adipocytokines and insulin resistance , 2003, Diabetologia.

[10]  J. Levy,et al.  Use and abuse of HOMA modeling. , 2004, Diabetes care.