Contrast enhancement of optical coherence tomography images using branched gold nanoparticles

We propose the use of branched gold nanoparticles (B-GNPs) as a contrast agent for optical coherence tomography (OCT) imaging. Our results show that even when the central source of our OCT (1325 nm) is too far from the maximum peak of the plasmon resonance, branched nanoparticles scatter light very efficiently at this wavelength. B-GNPs were tested as a contrast agent in water and agarose-TiO2 tissue phantoms; the estimated increments in contrast were 9.19 dB and 15.07 dB for branched nanoparticles in water with concentrations of 2.2 × 109 NPs/mL and 6.6 × 109 NPs/mL, respectively, while for agarose-TiO2 tissue phantoms the estimated value was 3.17 dB. These results show the promising application of B-GNPs as a contrast agent for tissue imaging using OCT, not only for sources at 1325nm but also at other central wavelengths located between 800 and 1000 nm.

[1]  Anant Agrawal,et al.  Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells. , 2006, Journal of biomedical optics.

[2]  L. Liz‐Marzán,et al.  High-yield synthesis and optical response of gold nanostars , 2008, Nanotechnology.

[3]  Jian Zhang,et al.  Concave cubic gold nanocrystals with high-index facets. , 2010, Journal of the American Chemical Society.

[4]  Srirang Manohar,et al.  Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics. , 2011, Nano letters.

[5]  J. Hafner,et al.  Plasmon resonances of a gold nanostar. , 2007, Nano letters.

[6]  Emilia Giorgetti,et al.  Synthesis and modelling of gold nanostars with tunable morphology and extinction spectrum , 2011 .

[7]  Haolong Li,et al.  In situ fabrication of flower-like gold nanoparticles in surfactant-polyoxometalate-hybrid spherical assemblies. , 2010, Chemical communications.

[8]  Younan Xia,et al.  Polyol Synthesis of Silver Nanoparticles: Use of Chloride and Oxygen to Promote the Formation of Single-Crystal, Truncated Cubes and Tetrahedrons , 2004 .

[9]  Claire M. Cobley,et al.  Controlling the synthesis and assembly of silver nanostructures for plasmonic applications. , 2011, Chemical reviews.

[10]  I. Kityk,et al.  Second order optical effects in Au nanoparticle-deposited ZnO nanocrystallite films , 2008, Nanotechnology.

[11]  Daniel L Marks,et al.  Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography. , 2004, Optics letters.

[12]  Young L. Kim,et al.  Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening. , 2006, Journal of biomedical optics.

[13]  Luis M Liz-Marzán,et al.  Shape control in gold nanoparticle synthesis. , 2008, Chemical Society reviews.

[14]  John Ballato,et al.  Monopod, bipod, tripod, and tetrapod gold nanocrystals. , 2003, Journal of the American Chemical Society.

[15]  T. Sakata,et al.  Synthesis and morphology of star-shaped gold nanoplates protected by poly(N -vinyl-2-pyrrolidone) , 2005 .

[16]  Catherine J. Murphy,et al.  Wet Chemical Synthesis of High Aspect Ratio Cylindrical Gold Nanorods , 2001 .

[17]  Liesbet Lagae,et al.  Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy. , 2011, ACS nano.

[18]  Joseph A Izatt,et al.  Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. , 2004, Optics letters.

[19]  S.A. Boppart.  Advances in Contrast Enhancement for Optical Coherence Tomography , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[20]  I. Kityk,et al.  Nonlinear optical properties of Au nanoparticles on indium–tin oxide substrate , 2005 .

[21]  Changhuei Yang,et al.  Molecular Contrast Optical Coherence Tomography: A Review¶ , 2005, Photochemistry and photobiology.

[22]  Francesco Stellacci,et al.  High-Yield Synthesis of Multi-Branched Urchin-Like Gold Nanoparticles , 2006 .

[23]  P. Nordlander,et al.  Plasmons in strongly coupled metallic nanostructures. , 2011, Chemical reviews.

[24]  J. Kimling,et al.  Turkevich method for gold nanoparticle synthesis revisited. , 2006, The journal of physical chemistry. B.

[25]  Joseph A Izatt,et al.  Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. , 2004, Optics letters.

[26]  Garnett W. Bryant,et al.  Metal‐nanoparticle plasmonics , 2008 .

[27]  Andrey L Rogach,et al.  Nonspherical Noble Metal Nanoparticles: Colloid‐Chemical Synthesis and Morphology Control , 2010, Advanced materials.

[28]  M Yu Kirillin,et al.  Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation , 2008, Physics in medicine and biology.

[29]  Scott C. Brown,et al.  Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives , 2011, Analytical and bioanalytical chemistry.

[30]  Robert Wilson.  The use of gold nanoparticles in diagnostics and detection. , 2008, Chemical Society reviews.

[31]  Jennifer K Barton,et al.  Optical coherence tomography with plasmon resonant nanorods of gold. , 2007, Optics letters.

[32]  Mostafa A. El-Sayed,et al.  Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method , 2003 .

[33]  Younan Xia,et al.  Gold nanocages as contrast agents for spectroscopic optical coherence tomography. , 2005, Optics letters.

[34]  Catherine J. Murphy,et al.  Seeding Growth for Size Control of 5−40 nm Diameter Gold Nanoparticles , 2001 .

[35]  Daniel X. Hammer,et al.  Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study , 2011, Biomedical optics express.