Toxicology and biocompatibility of bioglasses.

Evidence for the lack of toxicity of various bioglass formulations has been deduced from studies carried out, both in vivo and in vitro, in several different centers. Recent studies of the authors, described here, include testing of solid bioglass implants in the soft tissues of rats and rabbits for time periods of up to eight weeks. Two new techniques are described for the toxicological testing of particulate biomaterials. These tests, which involve rat peritoneal macrophages in culture and a mouse pulmonary biomaterial embolus model, indicate the biocompatibility of bioglass powders. Thus, the surface activity so critical in bone adhesion is without toxic effect in non-osseous tissues in contact with solid bioglass implants. Should wear occur and produce particulate bioglass, the material should be eliminated without consequence.

[1]  J. Autian,et al.  The new field of plastics toxicology--methods and results. , 1973, CRC critical reviews in toxicology.

[2]  E. Ethridge,et al.  The implantation of natural tooth form bioglasses in baboons. A preliminary report. , 1976, Oral surgery, oral medicine, and oral pathology.

[3]  L L Hench,et al.  Compositional dependence of the formation of calcium phosphate films on bioglass. , 1980, Journal of biomedical materials research.

[4]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[5]  S D Cook,et al.  Implant-bone interface characteristics of bioglass dental implants. , 1980, Journal of biomedical materials research.

[6]  Joshua R. Smith,et al.  Bone dynamics associated with the controlled loading of bioglass-coated aluminum oxide endosteal implants. , 1979, American journal of orthodontics.

[7]  B. Moffett,et al.  The loading of bioglass-coated aluminium oxide implants to produce sutural expansion of the maxillary complex in the pigtail monkey (Macaca nemestrina). , 1980, Archives of oral biology.

[8]  W. H. Lawrence,et al.  TOXICITY OF PLASTICS USED IN MEDICAL PRACTICE. I. INVESTIGATION OF TISSUE RESPONSE IN ANIMALS BY CERTAIN UNIT PACKAGED POLYVINYL CHLORIDE ADMINISTRATION DEVICES. , 1963, Journal of pharmaceutical sciences.

[9]  P. Kennedy,et al.  Pathology of domestic animals , 1970 .

[10]  J. Calnan The use of inert plastic material in reconstructive surgery. I. A biological test for tissue acceptance. II. Tissue reactions to commonly used materials. , 1963, British journal of plastic surgery.

[11]  L L Hench,et al.  Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial. , 1982, Journal of biomedical materials research.