Mutation scan of the D1 dopamine receptor gene in 22 cases of bipolar I disorder.

In a previous study [Coon et al., Am J Hum Genet 52:1234-1249, 1993], we found suggestive evidence of linkage between manic-depressive illness (MDI) in eight multiplex pedigrees and D5S62, a DNA marker mapping to the telomeric region of 5q. As the D1 dopamine receptor gene (DRD1) maps to this region and as alterations in dopaminergic neurotransmission have been indirectly implicated in the pathogenesis of MDI, we directly searched for mutations in the coding region of the DRD1 gene in 22 unrelated cases of bipolar I (BPI) disorder derived from multiplex families. Using single strand conformation polymorphism (SSCP) analysis, we did not observe any abnormal SSCP variants in the BPI cases that differed from controls.

[1]  M. Grompe,et al.  The rapid detection of unknown mutations in nucleic acids , 1993, Nature genetics.

[2]  H. Coon,et al.  A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance. , 1993, American journal of human genetics.

[3]  R. Sunahara,et al.  Schizophrenia: Dopamine D1 Receptor Sequence Is Normal, But Has DNA Polymorphisms , 1993, Neuropsychopharmacology.

[4]  D. Yandell,et al.  How sensitive is PCR‐SSCP? , 1993, Human mutation.

[5]  L. Kalaydjieva,et al.  High percentage acrylamide gels improve resolution in SSCP analysis. , 1992, Nucleic acids research.

[6]  T. Suppes,et al.  Clozapine in the treatment of dysphoric mania , 1992, Biological Psychiatry.

[7]  K. Sakimura,et al.  Molecular diversity of the NMDA receptor channel , 1992, Nature.

[8]  S. Nakanishi,et al.  A family of metabotropic glutamate receptors , 1992, Neuron.

[9]  D. Sibley,et al.  Molecular biology of dopamine receptors. , 1992, Trends in pharmacological sciences.

[10]  L. Heston,et al.  Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. , 1992, Genomics.

[11]  D. Grandy,et al.  Molecular biology of the dopamine receptors. , 1991, European journal of pharmacology.

[12]  Philip Seeman,et al.  Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine , 1991, Nature.

[13]  D. Grandy,et al.  A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP. , 1990, American journal of human genetics.

[14]  R. Rozmahel,et al.  Human dopamine D1 receptor encoded by an intronless gene on chromosome 5 , 1990, Nature.

[15]  D. Grandy,et al.  Cloning and expression of human and rat Dt dopamine receptors , 1990, Nature.

[16]  M. Caron,et al.  Molecular cloning and expression of the gene for a human D1 dopamine receptor , 1990, Nature.

[17]  C. Caskey,et al.  Molecular scanning methods of mutation detection. , 1990, The Journal of biological chemistry.

[18]  J. Ott.  Genetic linkage and complex diseases: A comment , 1990 .

[19]  N. Risch,et al.  Genetic linkage and complex diseases, with special reference to psychiatric disorders , 1990, Genetic epidemiology.

[20]  T. Sekiya,et al.  Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. , 1989, Genomics.

[21]  P. Seeburg,et al.  Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family , 1987, Nature.

[22]  J. Endicott,et al.  A diagnostic interview: the schedule for affective disorders and schizophrenia. , 1978, Archives of general psychiatry.

[23]  J. Mendlewicz,et al.  Adoption study supporting genetic transmission in manic–depressive illness , 1977, Nature.

[24]  A. Bertelsen,et al.  A Danish Twin Study of Manic-Depressive Disorders , 1977, British Journal of Psychiatry.

[25]  D. Murphy,et al.  Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients , 1971, Nature.