Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase‐catalysed bioactivation of nitroglycerin

Background and purpose:  Vascular tolerance to nitroglycerin (GTN) may be caused by impaired GTN bioactivation due to inactivation of mitochondrial aldehyde dehydrogenase (ALDH2). As relaxation to GTN is reduced but still sensitive to ALDH2 inhibitors in ascorbate deficiency, we compared the contribution of ALDH2 inactivation to GTN hyposensitivity in ascorbate deficiency and classical in vivo nitrate tolerance.

[1]  A. Daiber,et al.  Vascular tolerance to nitroglycerin in ascorbate deficiency: results are in favour of an important role of oxidative stress in nitrate tolerance. , 2008, Cardiovascular research.

[2]  B. Mayer,et al.  The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles , 2008, British journal of pharmacology.

[3]  B. Mayer,et al.  Vascular tolerance to nitroglycerin in ascorbate deficiency. , 2008, Cardiovascular research.

[4]  M. Weyand,et al.  Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  J. M. May,et al.  Inflammation in the vascular bed: importance of vitamin C. , 2008, Pharmacology & therapeutics.

[6]  W. Goessler,et al.  Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases* , 2008, Journal of Biological Chemistry.

[7]  B. Mayer.  Lack of evidence for a role of oxidative stress in vascular tolerance to nitroglycerin in ascorbate deficiency , 2008 .

[8]  D. Fernandes,et al.  Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation , 2008, Proceedings of the National Academy of Sciences.

[9]  R. Wadsworth,et al.  Selective Arterial Dilatation by Glyceryl Trinitrate Is Not Associated with Nitric Oxide Formation in vitro , 2008, Journal of Vascular Research.

[10]  C. Vahl,et al.  Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. , 2007, Journal of the American College of Cardiology.

[11]  T. Meinertz,et al.  Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation. , 2007, Journal of molecular and cellular cardiology.

[12]  R. Blomhoff,et al.  Stability of whole blood and plasma ascorbic acid , 2007, European Journal of Clinical Nutrition.

[13]  H. Weiner,et al.  Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH‐2−/− mice , 2007, British journal of pharmacology.

[14]  T. Münzel,et al.  Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity , 2007, Journal of Biological Chemistry.

[15]  J. Esplugues,et al.  Complex I Dysfunction and Tolerance to Nitroglycerin: An Approach Based on Mitochondrial-Targeted Antioxidants , 2006, Circulation research.

[16]  J. Stamler,et al.  Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. , 2006, Trends in cardiovascular medicine.

[17]  A. Banes,et al.  Ascorbic acid-independent synthesis of collagen in mice. , 2006, American journal of physiology. Endocrinology and metabolism.

[18]  J. Esplugues,et al.  Discrepancies Between Nitroglycerin and NO-Releasing Drugs on Mitochondrial Oxygen Consumption, Vasoactivity, and the Release of NO , 2005, Circulation research.

[19]  T. Münzel,et al.  Explaining the phenomenon of nitrate tolerance. , 2005, Circulation research.

[20]  T. Münzel,et al.  Heterozygous Deficiency of Manganese Superoxide Dismutase in Mice (Mn-SOD+/-): A Novel Approach to Assess the Role of Oxidative Stress for the Development of Nitrate Tolerance , 2005, Molecular Pharmacology.

[21]  Morris J. Brown,et al.  Aldehyde Dehydrogenase 2 Plays a Role in the Bioactivation of Nitroglycerin in Humans , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[22]  J. Stamler,et al.  An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[23]  John X. Wilson.  Regulation of vitamin C transport. , 2005, Annual review of nutrition.

[24]  B. Mayer,et al.  Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. , 2005, The Biochemical journal.

[25]  J. Stepien,et al.  Aldehyde dehydrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. , 2004, European journal of pharmacology.

[26]  J. Stamler,et al.  Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. , 2004, The Journal of clinical investigation.

[27]  V. Vasiliou,et al.  Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. , 2003, Molecular pharmacology.

[28]  T. Münzel,et al.  Does Nitric Oxide Mediate the Vasodilator Activity of Nitroglycerin? , 2003, Circulation research.

[29]  J. Stamler,et al.  Identification of the enzymatic mechanism of nitroglycerin bioactivation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Horowitz,et al.  Nitroglycerin Tolerance in Human Vessels: Evidence for Impaired Nitroglycerin Bioconversion , 2000, Circulation.

[31]  N. Maeda,et al.  Aortic wall damage in mice unable to synthesize ascorbic acid. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Taro Tokui,et al.  A family of mammalian Na+-dependent L-ascorbic acid transporters , 1999, Nature.

[33]  J. Horiot,et al.  Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat. , 1999, Free radical biology & medicine.

[34]  B. Peterkofsky,et al.  Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels. , 1999, The Journal of nutrition.

[35]  N. Fink,et al.  Dietary supplement with vitamin C prevents nitrate tolerance. , 1998, The Journal of clinical investigation.

[36]  B. Hinz,et al.  Vitamin C attenuates nitrate tolerance independently of its antioxidant effect , 1998, FEBS letters.

[37]  Y. Sugishita,et al.  Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. , 1998, Journal of the American College of Cardiology.

[38]  Y. Sugishita,et al.  Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure. , 1998, Circulation.

[39]  I. Tsukamoto,et al.  Change in the level of vitamin C and lipid peroxidation in tissues of the inherently scorbutic rat during ascorbate deficiency , 1996 .

[40]  F. Murad,et al.  Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines. , 1989, The Journal of pharmacology and experimental therapeutics.

[41]  A. Taylor,et al.  Relationship between dietary intake and tissue levels of reduced and total vitamin C in the nonscorbutic guinea pig. , 1989, The Journal of nutrition.

[42]  J. Brien,et al.  Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta. , 1986, The Journal of pharmacology and experimental therapeutics.