Cholesterol and statins in Alzheimer's disease: Current controversies

[1]  Matthew P. Frosch,et al.  The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease , 2010, Neuron.

[2]  Yaakov Stern,et al.  Contribution of vascular risk factors to the progression in Alzheimer disease. , 2009, Archives of neurology.

[3]  H. Ogura,et al.  Study of neuroprotection of donepezil, a therapy for Alzheimer's disease. , 2008, Chemico-biological interactions.

[4]  R. Resende,et al.  Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death , 2008, Neuroscience.

[5]  C. Oliveira,et al.  The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway , 2008, Neurobiology of Disease.

[6]  M. Lynch,et al.  A Pivotal Role for Interleukin-4 in Atorvastatin-associated Neuroprotection in Rat Brain* , 2008, Journal of Biological Chemistry.

[7]  Á. Martín-Requero,et al.  HMG-CoA Reductase Inhibitor Simvastatin Inhibits Cell Cycle Progression at the G1/S Checkpoint in Immortalized Lymphocytes from Alzheimer's Disease Patients Independently of Cholesterol-Lowering Effects , 2008, Journal of Pharmacology and Experimental Therapeutics.

[8]  S. Paul,et al.  Geranylgeranyl pyrophosphate stimulates γ‐secretase to increase the generation of Aβ and APP‐CTFγ , 2008 .

[9]  G. Landreth,et al.  Statins Reduce Amyloid-β Production through Inhibition of Protein Isoprenylation* , 2007, Journal of Biological Chemistry.

[10]  T. J. Lee,et al.  Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons. , 2007, American journal of physiology. Heart and circulatory physiology.

[11]  Yu Lin,et al.  The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation. , 2007, American journal of physiology. Heart and circulatory physiology.

[12]  Alun Williams,et al.  Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Aβ1–42 , 2007, Neuropharmacology.

[13]  P. Agostinho,et al.  Susceptibility of hippocampal neurons to Aβ peptide toxicity is associated with perturbation of Ca2+ homeostasis , 2007, Brain Research.

[14]  B. Tycko,et al.  Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome , 2007, Neuroscience Letters.

[15]  W. G. Wood,et al.  Simvastatin protects neurons from cytotoxicity by up‐regulating Bcl‐2 mRNA and protein , 2007 .

[16]  Shan Wang,et al.  The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. , 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[17]  T. Kashour,et al.  Lovastatin protects human neurons against Aβ-induced toxicity and causes activation of β-catenin–TCF/LEF signaling , 2007, Neuroscience Letters.

[18]  M. Nöldner,et al.  Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment , 2007, Neurobiology of Disease.

[19]  M. Lynch,et al.  The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β1–42 in the rat hippocampus in vivo , 2007, Neuropharmacology.

[20]  S. Teramukai,et al.  Prevention and Treatment of Dementia or Alzheimer’s Disease by Statins: A Meta-Analysis , 2007, Dementia and Geriatric Cognitive Disorders.

[21]  F. Panza,et al.  TOTAL CHOLESTEROL LEVELS AND THE RISK OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE , 2007, Journal of the American Geriatrics Society.

[22]  R. Lester,et al.  Simvastatin enhances learning and memory independent of amyloid load in mice , 2006, Annals of neurology.

[23]  B. Austen,et al.  Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. , 2006, The Biochemical journal.

[24]  J. Schulz,et al.  Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons , 2006, Neurobiology of Disease.

[25]  F. Panza,et al.  Lipid metabolism in cognitive decline and dementia , 2006, Brain Research Reviews.

[26]  T. Hartmann,et al.  Altered membrane fluidity and lipid raft composition in presenilin‐deficient cells , 2006, Acta neurologica Scandinavica. Supplementum.

[27]  J. Lehmann,et al.  Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin. , 2006, Journal of molecular biology.

[28]  B. Kriem,et al.  Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway , 2006, Neurobiology of Disease.

[29]  A. Chiloeches,et al.  RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion , 2006, Apoptosis.

[30]  K. Welsh-Bohmer,et al.  Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers , 2006, Neurology.

[31]  C Rosendorff,et al.  Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers , 2006, Neurology.

[32]  R. Wurtman,et al.  The 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons , 2006, Journal of neurochemistry.

[33]  J. Rutishauser The role of statins in clinical medicine--LDL--cholesterol lowering and beyond. , 2006, Swiss medical weekly.

[34]  Ding-I Yang,et al.  Statins Prevent β-Amyloid Inhibition of Sympathetic α7-nAChR-Mediated Nitrergic Neurogenic Dilation in Porcine Basilar Arteries , 2005 .

[35]  A. Nordberg,et al.  Lovastatin stimulates up‐regulation of α7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the α‐form of secreted amyloid precursor protein , 2005, Journal of neuroscience research.

[36]  T. Taverne,et al.  RAC1 Inhibition Targets Amyloid Precursor Protein Processing by γ-Secretase and Decreases Aβ Production in Vitro and in Vivo* , 2005, Journal of Biological Chemistry.

[37]  B. Strooper,et al.  Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin , 2005, Nature Cell Biology.

[38]  B. Miskie,et al.  Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease , 2005, Lipids in Health and Disease.

[39]  J. Koenigsknecht-Talboo,et al.  Mechanisms of Statin-mediated Inhibition of Small G-protein Function* , 2005, Journal of Biological Chemistry.

[40]  M. J. Bragado,et al.  Lovastatin inhibits the growth and survival pathway of phosphoinositide 3‐kinase/protein kinase B in immortalized rat brain neuroblasts , 2005, Journal of neurochemistry.

[41]  M. Endres Statins and Stroke , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[42]  Z. Nagy The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease , 2005, Journal of cellular and molecular medicine.

[43]  K. Blennow,et al.  Statin treatment and a disease-specific pattern of β-amyloid peptides in Alzheimer’s disease , 2005, Experimental Brain Research.

[44]  M. M. Mielke,et al.  High total cholesterol levels in late life associated with a reduced risk of dementia , 2005, Neurology.

[45]  R. Vassar,et al.  Statins Cause Intracellular Accumulation of Amyloid Precursor Protein, β-Secretase-cleaved Fragments, and Amyloid β-Peptide via an Isoprenoid-dependent Mechanism* , 2005, Journal of Biological Chemistry.

[46]  T. Kodama,et al.  Association of active γ-secretase complex with lipid rafts Published, JLR Papers in Press, Feburary 16, 2005. DOI 10.1194/jlr.M400333-JLR200 , 2005, Journal of Lipid Research.

[47]  Albert Hofman,et al.  Serum lipids and hippocampal volume: The link to Alzheimer's disease? , 2005, Annals of neurology.

[48]  Patrick Browne,et al.  Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. , 2005, Archives of neurology.

[49]  W. L. Ting,et al.  High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase , 2005, British journal of pharmacology.

[50]  Alexei R. Koudinov,et al.  Cholesterol homeostasis failure as a unifying cause of synaptic degeneration , 2005, Journal of the Neurological Sciences.

[51]  R. Lerner,et al.  Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. , 2005, Biochemistry.

[52]  P. Zuo,et al.  Effects of Aβ25–35 on neurogenesis in the adult mouse subventricular zone and dentate gyrus , 2005, Neurological research.

[53]  M. Endres,et al.  Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neurones , 2005, Journal of neurochemistry.

[54]  D. Alkon,et al.  Oxidation of Cholesterol by Amyloid Precursor Protein and β-Amyloid Peptide* , 2005, Journal of Biological Chemistry.

[55]  M. Schubert-Zsilavecz,et al.  Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex , 2005, Journal of Pharmacology and Experimental Therapeutics.

[56]  D. Sparks,et al.  Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. , 2005, Archives of general psychiatry.

[57]  Andrew Cordle,et al.  Neurobiology of Disease 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate-Amyloid-Induced Microglial Inflammatory Responses , 2005 .

[58]  D. Sparks,et al.  Is there a characteristic lipid profile in Alzheimer's disease? , 2005, Journal of Alzheimer's disease : JAD.

[59]  M. Ehrenstein,et al.  Statins for atherosclerosis--as good as it gets? , 2005, The New England journal of medicine.

[60]  G. Prendergast,et al.  Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK , 2005, PLoS medicine.

[61]  E. Hull,et al.  Nitric oxide mediates glutamate-evoked dopamine release in the medial preoptic area , 2004, Neuroscience.

[62]  C. Haass,et al.  A lipid boundary separates APP and secretases and limits amyloid β-peptide generation , 2004, The Journal of cell biology.

[63]  A. Delacourte,et al.  Neuronal membrane cholesterol loss enhances amyloid peptide generation , 2004, The Journal of cell biology.

[64]  B. Wolozin,et al.  Cholesterol, statins and dementia , 2004, Current opinion in lipidology.

[65]  R. Nitsch,et al.  BACE1 Overexpression Regulates Amyloid Precursor Protein Cleavage and Interaction with the ShcA Adapter , 2004, Annals of the New York Academy of Sciences.

[66]  M. Crisby,et al.  Rosuvastatin reduces caspase-3 activity and up-regulates α-secretase in human neuroblastoma SH-SY5Y cells exposed to Aβ , 2004, Neuroscience Letters.

[67]  E. Reiman,et al.  Vascular risk factors, incidence of MCI, and rates of progression to dementia , 2004, Neurology.

[68]  G. Lynch,et al.  Inhibition of Geranylgeranylation Mediates the Effects of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Inhibitors on Microglia* , 2004, Journal of Biological Chemistry.

[69]  E. B. Larson,et al.  Statin therapy and risk of dementia in the elderly , 2004, Neurology.

[70]  P. Wong,et al.  Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes* , 2004, Journal of Biological Chemistry.

[71]  Yun Bai,et al.  Lovastatin modulation of microglial activation via suppression of functional CD40 expression , 2004, Journal of neuroscience research.

[72]  M. Kuroda,et al.  Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. , 2004, FEBS letters.

[73]  C. Caltagirone,et al.  Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators , 2004, Neurobiology of Aging.

[74]  D. Selkoe,et al.  A Seed for Alzheimer Amyloid in the Brain , 2004, The Journal of Neuroscience.

[75]  E. Godaux,et al.  A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. , 2004, The Journal of clinical investigation.

[76]  B. Kriem,et al.  Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of the amyloid‐β peptide , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[77]  Eric J Topol,et al.  Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins , 2004, The Lancet.

[78]  M. Endres,et al.  HMG‐CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis , 2004, Journal of neurochemistry.

[79]  R. Nixon Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. , 2004, The American journal of pathology.

[80]  T. Bird,et al.  Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. , 2004, The American journal of pathology.

[81]  K. Blennow,et al.  Plasma Levels of β-Amyloid(1-40), β-Amyloid(1-42), and Total β-Amyloid Remain Unaffected in Adult Patients With Hypercholesterolemia After Treatment With Statins , 2004 .

[82]  M. Mattson,et al.  Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[83]  Y. Lyubchenko,et al.  Residues 17–20 and 30–35 of beta‐amyloid play critical roles in aggregation , 2004, Journal of neuroscience research.

[84]  T. Bayer,et al.  Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease Published, JLR Papers in Press, October 1, 2003. DOI 10.1194/jlr.M300320-JLR200 , 2004, Journal of Lipid Research.

[85]  K. Spence,et al.  3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity , 2003, The Journal of Neuroscience.

[86]  R. Mayeux,et al.  Stroke and the risk of Alzheimer disease. , 2003, Archives of neurology.

[87]  Valentina Gelfanova,et al.  Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho , 2003, Science.

[88]  T. Lüscher,et al.  Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. , 2003, Cardiovascular research.

[89]  D. Lütjohann,et al.  24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism , 2003, Pharmacopsychiatry.

[90]  J. H. Boo,et al.  Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice , 2003, Neurobiology of Aging.

[91]  S. Hazen,et al.  Statins Promote Potent Systemic Antioxidant Effects Through Specific Inflammatory Pathways , 2003, Circulation.

[92]  L. Thal,et al.  Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology , 2003, Neurology.

[93]  Elinor Miller,et al.  Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial). , 2003, The American journal of cardiology.

[94]  Deborah Gustafson,et al.  An 18-year follow-up of overweight and risk of Alzheimer disease. , 2003, Archives of internal medicine.

[95]  M. Mercken,et al.  Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo , 2003, The Journal of Neuroscience.

[96]  K. Duff,et al.  Use of in Vivo Models to Study the Role of Cholesterol in the Etiology of Alzheimer's Disease , 2003, Neurochemical Research.

[97]  D. Sparks,et al.  Is Cholesterol a Culprit in Alzheimer's Disease? , 2003, International Psychogeriatrics.

[98]  Yi Li,et al.  Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke , 2003, Annals of neurology.

[99]  W. G. Wood,et al.  Cholesterol Distribution in the Golgi Complex of DITNC1 Astrocytes Is Differentially Altered by Fresh and Aged Amyloid β-Peptide-(1–42)* , 2003, The Journal of Biological Chemistry.

[100]  K. Blennow,et al.  Treatment with Simvastatin in Patients with Alzheimer’s Disease Lowers Both α- and β-Cleaved Amyloid Precursor Protein , 2003, Dementia and Geriatric Cognitive Disorders.

[101]  S. DeKosky,et al.  22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion* , 2003, Journal of Biological Chemistry.

[102]  B. Strooper,et al.  Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex , 2003, Neuron.

[103]  Rudolph E. Tanzi,et al.  Alzheimer's disease: the cholesterol connection , 2003, Nature Neuroscience.

[104]  G. Eckert,et al.  Statin effects on cholesterol micro-domains in brain plasma membranes. , 2003, Biochemical pharmacology.

[105]  B. Winblad,et al.  Pulse Pressure and Risk of Alzheimer Disease in Persons Aged 75 Years and Older: A Community-Based, Longitudinal Study , 2003, Stroke.

[106]  E. Istvan,et al.  Statin inhibition of HMG-CoA reductase: a 3-dimensional view. , 2003, Atherosclerosis. Supplements.

[107]  Colin J Barrow,et al.  Cholesterol is necessary both for the toxic effect of Aβ peptides on vascular smooth muscle cells and for Aβ binding to vascular smooth muscle cell membranes , 2003, Journal of neurochemistry.

[108]  S. Lindgren,et al.  Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro. , 2003, Pharmacological research.

[109]  C. Haass,et al.  Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts , 2003, The Journal of cell biology.

[110]  T. Ohm,et al.  Blockade of HMG‐CoA reductase activity causes changes in microtubule‐stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease , 2003, The European journal of neuroscience.

[111]  E. Istvan Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. , 2002, American heart journal.

[112]  R. Campenot,et al.  Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann–Pick C1‐deficient neurons , 2002, Journal of neurochemistry.

[113]  V. Papadopoulos,et al.  22R‐Hydroxycholesterol protects neuronal cells from β‐amyloid‐induced cytotoxicity by binding to β‐amyloid peptide , 2002 .

[114]  P. Macfarlane,et al.  Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial , 2002, The Lancet.

[115]  S. Youssef,et al.  The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease , 2002, Nature.

[116]  K. Zou,et al.  Amyloid β‐protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade , 2002, Journal of neuroscience research.

[117]  F. Mach,et al.  Statins: the new aspirin? , 2002, Cellular and Molecular Life Sciences CMLS.

[118]  M. Hecker,et al.  3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase-Independent Inhibition of CD40 Expression by Atorvastatin in Human Endothelial Cells , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[119]  N. Arispe,et al.  Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AβP (1–40) and (1–42) peptides , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[120]  C. Rabiner,et al.  Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease , 2002, Neuroscience.

[121]  U. Igbavboa,et al.  Brain membrane cholesterol domains, aging and amyloid beta-peptides , 2002, Neurobiology of Aging.

[122]  Arto Mannermaa,et al.  Apolipoprotein E 4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease , 2002, Annals of Internal Medicine.

[123]  J. Liao Isoprenoids as mediators of the biological effects of statins. , 2002, The Journal of clinical investigation.

[124]  B. Winblad,et al.  Statins in the Prevention and Treatment of Alzheimer Disease , 2002, Alzheimer disease and associated disorders.

[125]  Y. Kozutsumi,et al.  Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. , 2002, Biochemistry.

[126]  Peter Schönknecht,et al.  Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls , 2002, Neuroscience Letters.

[127]  Xianwu Li,et al.  Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells* , 2002, The Journal of Biological Chemistry.

[128]  A. Zeiher,et al.  Double-Edged Role of Statins in Angiogenesis Signaling , 2002, Circulation research.

[129]  L. Launer,et al.  Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. , 2002, Diabetes.

[130]  J. Buxbaum,et al.  Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. , 2002, Frontiers in bioscience : a journal and virtual library.

[131]  D. Paris,et al.  Statins inhibit Aβ-neurotoxicity in vitro and Aβ-induced vasoconstriction and inflammation in rat aortae , 2002 .

[132]  B. de Strooper,et al.  A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[133]  J. Leverenz,et al.  Diet-induced hypercholesterolemia enhances brain A&bgr; accumulation in transgenic mice , 2002, Neuroreport.

[134]  E. Barrett-Connor,et al.  Serum lipoprotein levels, statin use, and cognitive function in older women. , 2002, Archives of neurology.

[135]  R. Pepperkok,et al.  Inhibition of Intracellular Cholesterol Transport Alters Presenilin Localization and Amyloid Precursor Protein Processing in Neuronal Cells , 2002, The Journal of Neuroscience.

[136]  Á. Pascual,et al.  3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. , 2002, Atherosclerosis.

[137]  C. Heeschen,et al.  Statins Have Biphasic Effects on Angiogenesis , 2002, Circulation.

[138]  S. Younkin,et al.  Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains , 2002, Neurobiology of Disease.

[139]  U. Beisiegel,et al.  Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. , 2002, Archives of neurology.

[140]  K. Zou,et al.  Cholesterol‐dependent modulation of dendrite outgrowth 
and microtubule stability in cultured neurons , 2002, Journal of neurochemistry.

[141]  C. Göritz,et al.  CNS synaptogenesis promoted by glia-derived cholesterol. , 2001, Science.

[142]  A. Sidhu,et al.  Neurodegeneration in Niemann-Pick type C disease mice , 2001, Experimental Brain Research.

[143]  J. Marx Bad for the Heart, Bad For the Mind? , 2001, Science.

[144]  M. Mercken,et al.  A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease , 2001, Neurobiology of Disease.

[145]  B. Hyman,et al.  Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide , 2001, Nature Cell Biology.

[146]  A. McIntosh,et al.  Recent Advances in Membrane Microdomains: Rafts, Caveolae, and Intracellular Cholesterol Trafficking , 2001, Experimental biology and medicine.

[147]  J. Seeger,et al.  Clinically relevant differences between the statins: implications for therapeutic selection. , 2001, The American journal of medicine.

[148]  J. Dichgans,et al.  Cholesterol and Alzheimer’s disease , 2001, Neurology.

[149]  P. Mcgeer,et al.  3-Hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain , 2001, Neuroreport.

[150]  Q. Fan,et al.  A Novel Action of Alzheimer's Amyloid β-Protein (Aβ): Oligomeric Aβ Promotes Lipid Release , 2001, The Journal of Neuroscience.

[151]  A. Koudinov,et al.  Essential role for cholesterol in synaptic plasticity and neuronal degeneration , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[152]  David J. Cummins,et al.  Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[153]  J Tuomilehto,et al.  Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study , 2001, BMJ.

[154]  T. Ohm,et al.  Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons , 2001, Acta Neuropathologica.

[155]  Joerg Kallen,et al.  Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site , 2001, Nature Medicine.

[156]  B. Wolozin A fluid connection: Cholesterol and Aβ , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[157]  E. Kojro,et al.  Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[158]  G. Reichmann,et al.  Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation1 , 2001, The Journal of Immunology.

[159]  A Ogunniyi,et al.  Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana. , 2001, JAMA.

[160]  Y. Ihara,et al.  Accumulation and Aggregation of Amyloid β-Protein in Late Endosomes of Niemann-Pick Type C Cells* , 2001, The Journal of Biological Chemistry.

[161]  A. Álvarez,et al.  Lovastatin Induces Apoptosis of Spontaneously Immortalized Rat Brain Neuroblasts: Involvement of Nonsterol Isoprenoid Biosynthesis Inhibition , 2001, Molecular and Cellular Neuroscience.

[162]  Q. Fan,et al.  Cholesterol‐dependent modulation of tau phosphorylation in cultured neurons , 2001, Journal of neurochemistry.

[163]  J. Poirier,et al.  Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism , 2000, Annals of the New York Academy of Sciences.

[164]  H Jick,et al.  Statins and the risk of dementia , 2000, The Lancet.

[165]  Joachim Herz,et al.  Apolipoprotein E receptors: linking brain development and alzheimer's disease , 2000, Nature Reviews Neuroscience.

[166]  I. Shiojima,et al.  The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. , 2000, Nature Medicine.

[167]  C. Schnitzler,et al.  BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein , 2000 .

[168]  Rong Wang,et al.  Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model , 2000, Neurobiology of Disease.

[169]  R Brookmeyer,et al.  Age-specific incidence rates of Alzheimer’s disease , 2000, Neurology.

[170]  M. Kitagawa,et al.  Geranylgeranyl-Pyrophosphate, an Isoprenoid of Mevalonate Cascade, Is a Critical Compound for Rat Primary Cultured Cortical Neurons to Protect the Cell Death Induced by 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibition , 2000, The Journal of Neuroscience.

[171]  O. F. Olesen,et al.  High Density Lipoprotein Inhibits Assembly of Amyloid β-Peptides into Fibrils , 2000 .

[172]  F. Jessen,et al.  Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. , 2000, Journal of lipid research.

[173]  R. Doms,et al.  Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network* , 2000, The Journal of Biological Chemistry.

[174]  K. Suzuki,et al.  Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. , 1999, The Biochemical journal.

[175]  R. Mayeux,et al.  APOE genotype, plasma lipids, lipoproteins, and AD in community elderly , 1999, Neurology.

[176]  D J Stephens,et al.  The role of cholesterol in the biosynthesis of beta-amyloid. , 1999, Neuroreport.

[177]  C. Haass,et al.  Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture* , 1999, The Journal of Biological Chemistry.

[178]  E. Larson,et al.  Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA: the Kame Project. , 1999, The journals of gerontology. Series B, Psychological sciences and social sciences.

[179]  E. Larson,et al.  Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA , 1999 .

[180]  M. Emmerling,et al.  Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels. , 1998, Biochemical and biophysical research communications.

[181]  D. Peterson,et al.  Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[182]  Joseph D. Buxbaum,et al.  Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor* , 1998, The Journal of Biological Chemistry.

[183]  B. Greenberg,et al.  Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol* , 1998, The Journal of Biological Chemistry.

[184]  B. Strooper,et al.  Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[185]  R. Perona,et al.  Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases* , 1998, The Journal of Biological Chemistry.

[186]  A. Namboodiri,et al.  Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. , 1997, The Journal of clinical investigation.

[187]  C. Masters,et al.  Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides , 1997, Nature Medicine.

[188]  D. Wilson,et al.  Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. , 1997, The American journal of pathology.

[189]  A. Fagan,et al.  High density lipoprotein decreases β‐amyloid toxicity in cortical cell culture , 1997 .

[190]  T. Iwatsubo,et al.  The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[191]  A. Hofman,et al.  Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study , 1997, The Lancet.

[192]  B. Austen,et al.  Metabolites of the β‐amyloid precursor protein generated by β‐secretase localise to the trans‐golgi network and late endosome in 293 cells , 1996 .

[193]  Y. Wu,et al.  Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. , 1996, Biophysical journal.

[194]  W. G. Wood,et al.  Increasing Age Alters Transbilayer Fluidity and Cholesterol Asymmetry in Synaptic Plasma Membranes of Mice , 1996, Journal of neurochemistry.

[195]  W. Klein,et al.  Cholesterol Modulates -Secretase Cleavage of Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.

[196]  L. McConlogue,et al.  Differential Effects of a Rab6 Mutant on Secretory Versus Amyloidogenic Processing of Alzheimers -Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.

[197]  L. McConlogue,et al.  The Ras-related GTP-binding Protein, Rab1B, Regulates Early Steps in Exocytic Transport and Processing of β-Amyloid Precursor Protein (*) , 1995, The Journal of Biological Chemistry.

[198]  L. Svennerholm,et al.  Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years , 1994, Journal of neurochemistry.

[199]  M. Pericak-Vance,et al.  Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[200]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[201]  P. Matsudaira,et al.  Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[202]  D. Sparks,et al.  Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease , 1990, Neurobiology of Aging.

[203]  J. Hayes,et al.  Lecithin: cholesterol acyltransferase in Down's syndrome. , 1983, Clinica chimica acta; international journal of clinical chemistry.

[204]  M. Kuroda,et al.  Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity , 1976, Atherosclerosis. Supplements.

[205]  F. Rivero,et al.  Rho GTPases , 2012, Methods in Molecular Biology.

[206]  C. Oliveira,et al.  Neuroprotective effects of statins in an in vitro model of Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.

[207]  A. Miserez,et al.  Statins induce differentiation and cell death in neurons and astroglia , 2007, Glia.

[208]  D. Jun,et al.  Differential effects of statins and alendronate on cholinesterases in serum and brain of rats. , 2007, Physiological research.

[209]  T. Kashour,et al.  Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. , 2007, Neuroscience letters.

[210]  W. G. Wood,et al.  Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice , 2007, NeuroMolecular Medicine.

[211]  A. Confaloni,et al.  Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE , 2007, Journal of Molecular Neuroscience.

[212]  B. Wolff,et al.  ISOPRENOID DEPLETION BY STATINS ANTAGONIZES CYTOKINE , 2007 .

[213]  L. Puglielli,et al.  Role of acyl-coenzyme A , 2007, Journal of Molecular Neuroscience.

[214]  S. Mayer,et al.  Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage , 2006, Neurology.

[215]  Ding-I Yang,et al.  Statins prevent beta-amyloid inhibition of sympathetic alpha7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[216]  S. Filipek,et al.  Genetic aspects of Alzheimer's disease. , 2004, Acta neurobiologiae experimentalis.

[217]  H. Braak,et al.  Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. , 2003, Archives of neurology.

[218]  F. Pfrieger Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[219]  F. Jessen,et al.  24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. , 2002, Journal of psychiatric research.

[220]  D. Paris,et al.  Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. , 2002, Atherosclerosis.

[221]  H. Zhang,et al.  Huperzine A attenuates amyloid β‐peptide fragment 25‐35‐induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase‐3 activation , 2002, Journal of neuroscience research.

[222]  Vicki Olm,et al.  Statin therapy for Alzheimer's disease: will it work? , 2002, Journal of molecular neuroscience : MN.

[223]  V. Papadopoulos,et al.  22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. , 2002, Journal of neurochemistry.

[224]  P. M. Davis,et al.  Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors. , 2001, International immunopharmacology.

[225]  J. Buxbaum,et al.  Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. , 2001, Journal of Alzheimer's disease : JAD.

[226]  T. Kubo,et al.  Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments. , 2001, Neuroscience.

[227]  M. Hennerici,et al.  Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[228]  O. F. Olesen,et al.  High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils. , 2000, Biochemical and biophysical research communications.

[229]  Brian,et al.  THE ROLE OF CHOLESTEROL IN BIOSYNTHESIS OF β-AMYLOID , 1999 .

[230]  A. Fagan,et al.  High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture. , 1997, Neuroreport.