angiogenesis angiopoietin-1 and its potential relationship to myeloma-induced Proangiogenic properties of human myeloma cells: production of

doi:10.1182/blood-2002-10-3257Prepublished online March 20, 2003;2003 102: 638-645€€€€Caramatti, Lina Mangoni and Vittorio RizzoliPier Paolo Fattori, Gabriella Sammarelli, Gian Carlo Gazzola, Regis Bataille, Camillo Almici, CeciliaSabrina Bonomini, Paolo Lunghi, Magda Hojden, Giovenzio Genestreti, Mirija Svaldi, Paolo Coser, Nicola Giuliani, Simona Colla, Mirca Lazzaretti, Roberto Sala, Giovanni Roti, Cristina Mancini,€

[1]  Thomas N. Sato,et al.  Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. , 1997, Science.

[2]  P. Richardson,et al.  Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications , 2001, Leukemia.

[3]  K. Pienta,et al.  Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line. , 1998, Journal of the National Cancer Institute.

[4]  T. Suda,et al.  In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells. , 1999, Biochemical and biophysical research communications.

[5]  M. Jourdan,et al.  Spontaneous secretion of tumor necrosis factor‐beta by human myeloma cell lines , 1989, Cancer.

[6]  B. Bussolati,et al.  Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. , 2001, The American journal of pathology.

[7]  G. Yancopoulos,et al.  New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF , 1999, Oncogene.

[8]  A. Waage,et al.  Concomitant Expression of Hepatocyte Growth Factor/Scatter Factor and the Receptor c-MET in Human Myeloma Cell Lines* , 1996, The Journal of Biological Chemistry.

[9]  P. Richardson,et al.  Novel therapies targeting the myeloma cell and its bone marrow microenvironment. , 2001, Seminars in oncology.

[10]  P. Oettgen,et al.  NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin‐1: A potential mechanism for Tie2 regulation during hypoxia , 2002, Journal of cellular biochemistry.

[11]  S. Kitano,et al.  Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. , 2001, Cancer research.

[12]  M. Dewhirst,et al.  Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. , 1997, The Journal of clinical investigation.

[13]  H. Namba,et al.  Tie-2 and angiopoietin-1 expression in human thyroid tumors. , 2002, Thyroid : official journal of the American Thyroid Association.

[14]  D. Ribatti,et al.  Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. , 1999, Blood.

[15]  P. Rood,et al.  Immortalisation of human bone marrow endothelial cells: characterisation of new cell lines , 2000, European journal of clinical investigation.

[16]  M. Shikami,et al.  Expression of endothelial cell-associated molecules in AML cells , 2002, Leukemia.

[17]  G. Yancopoulos,et al.  Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. , 1998, Immunity.

[18]  W. Bellamy Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies. , 2001, Seminars in oncology.

[19]  Thomas N. Sato,et al.  Increased vascularization in mice overexpressing angiopoietin-1. , 1998, Science.

[20]  J. Partanen,et al.  Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells , 1997, British journal of haematology.

[21]  S. Tian,et al.  Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1 , 2002, British Journal of Cancer.

[22]  K. Wagner,et al.  Tie2 Receptor Expression Is Stimulated by Hypoxia and Proinflammatory Cytokines in Human Endothelial Cells , 2000, Circulation research.

[23]  Stanley J. Wiegand,et al.  Vascular-specific growth factors and blood vessel formation , 2000, Nature.

[24]  Y. Kotake,et al.  Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  A. Feller,et al.  Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid leukemia. , 2002, Leukemia research.

[26]  M. Jourdan,et al.  Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. , 1994, Blood.

[27]  S. McLeskey,et al.  Expression and function of angiopoietin-1 in breast cancer , 2000, British Journal of Cancer.

[28]  R. Fonseca,et al.  Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[29]  T. Sonoki,et al.  Expressions of vascular endothelial growth factor and angiopoietin-2 in myeloma cells. , 2003, Haematologica.

[30]  N. Munshi,et al.  Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis. , 2001, Seminars in oncology.

[31]  W. Berdel,et al.  Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. , 2000, Blood.

[32]  M. Jourdan,et al.  Cytokine gene expression in human multiple myeloma , 1993, British journal of haematology.

[33]  K. Plate,et al.  Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. , 1998, The American journal of pathology.

[34]  D. Ribatti,et al.  Bone marrow angiogenesis in patients with active multiple myeloma. , 2001, Seminars in oncology.

[35]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[36]  M. Mollenauer,et al.  Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression. , 2001, Blood.

[37]  J. Lim,et al.  Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells. , 2001, Investigative ophthalmology & visual science.

[38]  M. Makuuchi,et al.  Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. , 1999, The Journal of clinical investigation.