Relatively anterior lens position in primary angle-closure glaucoma eyes with long axial length

Purpose: To evaluate the refractive status and ocular biometric parameters in primary angle-closure glaucoma (PACG) eyes with different axial lengths (ALs). Methods: In total, 742 Chinese PACG subjects with complete ophthalmic examinations were enrolled. The refractive status was categorized as myopia (spherical equivalent [SE] ≤−0.5 D), emmetropia (−0.5 D < SE < +0.5 D), and hyperopia (SE ≥+0.5 D), whereas the AL was divided into short (AL <22.5 mm), regular (22.5 ≤ AL <23.5 mm), and long (AL ≥23.5 mm). The refractive status and ocular biometric parameters were compared among different AL groups. Results: The mean AL of the PACG eyes was 22.53 ± 0.84 mm (range: 19.68–25.57 mm). The refractive status was significantly different among different AL groups (P < 0.001). Also, 92.6% of hyperopic PACG eyes showed AL <23.5 mm, and 19.0% of myopic PACG eyes showed AL ≥23.5 mm. The SE showed significant differences among different AL groups only in the hyperopic subjects (P = 0.012). The AL was significantly longer in myopic eyes (P < 0.001). The PACG eyes with longer AL exhibited lower keratometry, longer central anterior chamber depth and corneal diameter, and lens position and relative lens position closer to the anterior (P < 0.001). Conclusion: Axial hyperopia was common in PACG eyes, and axial myopia was not uncommon. Relatively anterior lens position could explain the occurrence of PACG in the eyes with long AL.

[1]  Narendra K. Puttaiah,et al.  Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma. , 2020, Journal of glaucoma.

[2]  R. Husain,et al.  Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease , 2020, Ophthalmic Research.

[3]  Xinghuai Sun,et al.  Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine , 2019, EPMA Journal.

[4]  Tin Aung,et al.  Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial , 2019, The Lancet.

[5]  Xinghuai Sun,et al.  What Are the Characteristics of Primary Angle Closure With Longer Axial Length? , 2018, Investigative ophthalmology & visual science.

[6]  Jelinar Mohamed-Noor,et al.  Refractive errors and biometry of primary angle-closure disease in a mixed Malaysian population. , 2017, International journal of ophthalmology.

[7]  X. Kong,et al.  Changes of anterior segment parameters in primary angle closure with axial myopia: a retrospective study of 369 patients grouped by axial length , 2016, Acta ophthalmologica.

[8]  Peiquan Zhao,et al.  Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study , 2016, PloS one.

[9]  M. He,et al.  Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes. , 2015, Investigative ophthalmology & visual science.

[10]  M. He,et al.  Does Myopia Affect Angle Closure Prevalence. , 2015, Investigative ophthalmology & visual science.

[11]  T. Wong,et al.  Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. , 2014, Ophthalmology.

[12]  T. Aung,et al.  Myopia in asian subjects with primary angle closure: implications for glaucoma trends in East Asia. , 2014, Ophthalmology.

[13]  P. Mitchell,et al.  Myopia, axial length, and age-related cataract: the Singapore Malay eye study. , 2013, Investigative ophthalmology & visual science.

[14]  S. Chatterjee,et al.  Acute primary angle closure in a patient with high myopia: a case report. , 2013, Journal of the Indian Medical Association.

[15]  D. Sherpa,et al.  Association between axial length of the eye and primary angle closure glaucoma. , 2009, Kathmandu University medical journal.

[16]  J. Jonas,et al.  Anterior chamber depth and chamber angle and their associations with ocular and general parameters: the Beijing Eye Study. , 2008, American journal of ophthalmology.

[17]  G. Spaeth,et al.  The Prevalence of Myopia in Eyes With Angle Closure , 2007, Journal of glaucoma.

[18]  D. Walton,et al.  Anterior axial lens subluxation, progressive myopia, and angle-closure glaucoma: recognition and treatment of atypical presentation of ectopia lentis. , 2006, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[19]  R. Ritch,et al.  Angle closure in highly myopic eyes. , 2006, Ophthalmology.

[20]  P. Mitchell,et al.  Five-year refractive changes in an older population: the Blue Mountains Eye Study. , 2003, Ophthalmology.

[21]  R. Lowe,et al.  Aetiology of the anatomical basis for primary angle-closure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma. , 1970, The British journal of ophthalmology.

[22]  N. Risch,et al.  The Association of Refractive Error with Glaucoma in a Multiethnic Population. , 2016, Ophthalmology.

[23]  G. Marchini,et al.  New findings in the diagnosis and treatment of primary angle-closure glaucoma. , 2015, Progress in brain research.