Protocol for X-ray dosimetry in radiobiology

Purpose : To harmonize X-ray dosimetry in radiobiology to allow a direct comparison of radiobiological studies performed at institutes cooperating within the framework of the European Late Effects Project Group (EULEP). Materials and methods : The 1985 EULEP protocol for X-ray dosimetry and exposure arrangements employed for studies of late somatic effects in mammals required serious revision, e.g. due to the replacement of calibration of dosemeters in terms of exposure by calibration in terms of air kerma free-in-air. An action group established by EULEP and the European Radiation Dosimetry Group (EURADOS) updated the 1985 protocol. Results : The new EULEP-EURADOS protocol for X-ray dosimetry in radiobiology including the code of practice for irradiation of small animals and related dosimetry. The present protocol includes the changes in calibration procedures and dosimetric concepts for irradiation with medium energy X-rays since 1985. Accuracy and precision are replaced by the concept of combined (standard) uncertainty. The revised supplements provide more detailed background information. New appendices contain definitions of general terms used for measurements and mathematical expressions of the relative variances. Conclusion : Adherence to the present protocol will result in improved dosimetry and facilitates the comparison of results of radiobiological experiments obtained at different institutes.

[1]  I Nikl,et al.  Dose to the shielded thymic region of irradiated mouse cadavers. , 1977, Acta radiologica: therapy, physics, biology.

[2]  J. Hendry,et al.  Quantitative Concepts and Dosimetry in Radiobiology , 1980 .

[3]  J. H. Hendry.  Protocol for X-ray Dosimetry , 1985 .

[4]  Frank Herbert Attix,et al.  A solid water phantom material for radiotherapy x‐ray and γ‐ray beam calibrations , 1982 .

[5]  A J van der Kogel,et al.  Effect of misonidazole on the tolerance of the rat spinal cord to daily and multiple fractions per day of X rays. , 1983, The British journal of radiology.

[6]  I Nikl.  Development of media suitable for dose measurement. Dose measurement media. , 1969, Acta biochimica et biophysica; Academiae Scientiarum Hungaricae.

[7]  日本規格協会.  試験所及び校正機関の能力に関する一般要求事項 = General requirements for the competence of testing and calibration laboratories = Prescriptions générales concernant la compétence des laboratoires d'étalonnages et d'essais , 2000 .

[8]  J Zoetelief,et al.  Protocol for X-ray dosimetry and exposure arrangements employed in studies of late somatic effects in mammals. , 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[9]  J Zoetelief,et al.  Recent EULEP dosimetry intercomparisons for whole body irradiation of mice. European Late Effects Project group. , 1997, International journal of radiation biology.

[10]  J Zoetelief,et al.  Effective measuring point of ion chambers for photon dosimetry in phantoms. , 1980, The British journal of radiology.

[11]  Ezio Caroli,et al.  A catalogue of X-ray spectra of AGNs: Data presentation and analysis , 1992 .

[12]  Michael Goitein,et al.  Nonstandard deviations: Communications , 1983 .

[13]  J Zoetelief,et al.  Calculated energy response correction factors for LiF thermoluminescent dosemeters employed in the seventh EULEP dosimetry intercomparison. , 1997, Physics in medicine and biology.

[14]  A. Nahum,et al.  Calculations of ion chamber displacement effect corrections for medium-energy x-ray dosimetry. , 1995, Physics in medicine and biology.

[15]  R. Cloutier.  Tissue Substitutes in Radiation Dosimetry and Measurement. , 1989 .

[16]  B R Paliwal,et al.  A solid water phantom material for radiotherapy x-ray and gamma-ray beam calibrations. , 1982, Medical physics.

[17]  F Verhaegen,et al.  Dependence of overall correction factor of a cylindrical ionization chamber on field size and depth in medium-energy x-ray beams. , 1996, Medical physics.

[18]  D Harder,et al.  Muscle- and fat-equivalent polyethylene-based phantom materials for x-ray dosimetry at tube voltages below 100 kV. , 1986, Physics in medicine and biology.

[19]  J Zoetelief,et al.  Dosimetry intercomparison for partial body x-irradiation of rats. , 1980, Physics in medicine and biology.

[20]  D. R. White,et al.  Anthropomorphic Phantom Materials , 1982 .

[21]  G Scarpa,et al.  Use of thermoluminescent dosimeters for measuring dose distribution with high spatial resolution in partial-body irradiation of small animals. , 1979, The British journal of radiology.

[22]  J. Zoetelief,et al.  Protocol for X-ray dosimetry : EULEP , 1985 .

[23]  J Zoetelief,et al.  Dosimetry for total body irradiation of rhesus monkeys with 300 kV X-rays. , 1998, International journal of radiation biology.

[24]  A Wambersie,et al.  What degree of accuracy is required and can be achieved in photon and neutron therapy? , 1987, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.