Fabrication and comparison of MoS2 and WSe2 field-effect transistor biosensors

The authors present a study on the evolution behaviors of the transfer characteristics of MoS2 and WSe2 field-effect transistor biosensors when they are subjected to tumor necrosis factor-alpha and streptavidin solutions with varying analyte concentrations. Both MoS2 and WSe2 sensors exhibit very low detection limits (∼60 fM for tumor necrosis factor-alpha detection; ∼70 fM for streptavidin detection). However, WSe2 sensors exhibit the higher linear-regime sensitivities in comparison with MoS2 sensors. In particular, WSe2 sensors exhibit high linear-regime sensitivities up to ∼1.54%/fM for detecting streptavidin at a concentration of ∼70 fM. Such relatively higher sensitivities obtained from WSe2 sensors are attributed to their intrinsic ambipolar transfer characteristics, which make their ON-state carrier concentrations significantly lower than those of MoS2 sensors, and therefore, the target-molecule-induced doping effect results in more prominent channel conductance modulation in WSe2 transistor sensor...

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