Assessment of Liver Enzymes , Creatine Phosphokinase and Electrolytes in Hypothyroid Patients Visiting Tertiary Centre

Various biochemical alteration in hypothyroidism has already been established. Since majority of metabolic activities occur in liver; kidney and muscle in body, so biochemical markers reflecting function of these organs are altered in hypothyroid state. The present study is designed to compare the level of enzymes like Serum Glutamate Pyruvate Transferase (SGPT), Serum Glutamate Oxaloacetate Transferase (SGOT), Alkaline Phosphatase (ALP) and Creatine Phosphokinase(CPK) along with electrolytes (Sodium, Potassium) in clinically hypothyroid patients with age and sex matched control subjects. The Study was conducted in patients visiting to Endocrinology OPD in Institute of Medicine, Nepal. Total of 49 patients diagnosed as hypothyroidism in age group 20-70 were included in the study. Patients with TSH values above 10 mIU/L were taken as cases. Total 49 individuals were taken as control in whom age and sex was matched. The mean SGOT, ALP and CPK in Hypothyroid patients was 31.65 ± 8.53IU/L, 215.96 ± 53.23U/L and 104.77 ± 47.55IU/L respectively which were significantly increased in comparison with mean value from control subjects. The mean value of SPGT was 25.73 ± 10.12IU/L which was statistically not significant as compared to normal. Likewise, the mean value of Sodium and Potassium was 138.54 ± 4.41 and 4.19 ± 0.37 which was within the normal range and statistically not significant with the control. Enzymes like SGOT, ALP & CPK level are significantly increased in hypothyroid patient and this increase is more likely due to muscle involvement in hypothyroidism.