Antibacterial evaluation of some benzimidazole derivatives and their zinc(II) complexes

Zinc(II) chloride was reacted with some 1-benzylbenzimidazole deriva- tives (L) to give complexes of the formula ZnL 2 Cl 2 . All the ligands and their zinc(II) complexes were evaluated for their in vitro antibacterial activity against Pseudomo- nas aeruginosa, Bacillus cereus, Staphylococcus aureus and Sarcina lutea .T he ma- jority of the investigated compounds displayed in vitro antimicrobial activity aga- inst very persistent microorganisms. It was found that all the tested compounds were more active against gram-positive than gram-negative bacteria. The minimum in- hibitory concentration (MIC) was determined for all ligands and their complexes. The effect of the structure of the ligands and complexes on the antimicrobial activity is discussed. The complexes were found to be more toxic than the ligands.

[1]  D. Boykin,et al.  Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines. , 2005, European journal of medicinal chemistry.

[2]  J. D. Baldeck,et al.  Antimicrobial actions of benzimidazoles against oral streptococci. , 2005, Oral microbiology and immunology.

[3]  A. Khalafi-nezhad,et al.  Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives. , 2005, Bioorganic & medicinal chemistry.

[4]  Hacer Karatas,et al.  Synthesis and Potent Antimicrobial Activity of Some Novel 4‐(5, 6‐Dichloro‐1H‐benzimidazol‐2‐yl)‐N‐substituted Benzamides , 2004, Archiv der Pharmazie.

[5]  R. Butcher,et al.  Spectroscopic, structural and antibacterial properties of copper(II) complexes with bio-relevant 5-methyl-3-formylpyrazole N(4)-benzyl-N(4)-methylthiosemicarbazone , 2003, Molecular and Cellular Biochemistry.

[6]  F. Perna,et al.  Antimicrobial activity of esomeprazole versus omeprazole against Helicobacter pylori. , 2003, The Journal of antimicrobial chemotherapy.

[7]  H. Alakomi,et al.  Characterization of the action of selected essential oil components on gram-negative bacteria , 1998 .

[8]  J. Canadanovic-Brunet,et al.  Synthesis, AntiBacteriol, and Antifungal Activities of Some New Benzimidazoles. , 1992, Bioscience, biotechnology, and biochemistry.

[9]  E. Bruck,et al.  National Committee for Clinical Laboratory Standards. , 1980, Pediatrics.

[10]  D. Cvetković,et al.  Antibacterial and antifungal activity of zinc(II) complexes with some 2-methylbenzimidazole derivatives , 2005 .

[11]  O. S. Podunavac-Kuzmanovic,et al.  SYNTHESIS, PHYSICO-CHEMICAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF 2-AMINOBENZIMIDAZOLE COMPLEXES WITH DIFFERENT METAL IONS , 2004 .

[12]  F. Hirayama,et al.  Potent antibacterial activity of Y-754, a novel benzimidazole compound with selective action against Helicobacter pylori , 2004, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[13]  R. Hancock,et al.  The bacterial outer membrane as a drug barrier. , 1997, Trends in microbiology.