Role of Hageman factor in the initiation of clotting by glass; evidence that glass frees Hageman factor from inhibition.

Abstract Evidence is presented that the clot-promoting effect of glass or of certain other adsorbents upon normal human plasma requires the presence of Hageman factor. Human or duck plasma, deficient in Hageman factor, inhibited the clot-promoting effect of glass or barium carbonate upon normal human plasma. The clot-promoting property of normal plasma, once activated, deteriorated rapidly, apparently as the result of enzymatic destruction. These observations suggest that the fluidity of blood within blood vessels may be maintained by inhibitors directed against Hageman factor.

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