CRISPR/Cas9‐mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β‐1,2‐xylose and core α‐1,3‐fucose
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Rainer Fischer | Markus Sack | Sruthy Maria Augustine | Julia Jansing | Luisa Bortesi | R. Fischer | M. Sack | S. M. Augustine | L. Bortesi | Julia Jansing
[1] Lisa Hensley,et al. Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques , 2012, Proceedings of the National Academy of Sciences.
[2] R. Hellens,et al. Advanced Engineering of Lipid Metabolism in Nicotiana benthamiana Using a Draft Genome and the V2 Viral Silencing-Suppressor Protein , 2012, PloS one.
[3] P. Lerouge,et al. Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose. , 2003, Glycobiology.
[4] M. Sack,et al. Putting the Spotlight Back on Plant Suspension Cultures , 2016, Front. Plant Sci..
[5] F. Altmann,et al. Reduced paucimannosidic N‐glycan formation by suppression of a specific β‐hexosaminidase from Nicotiana benthamiana , 2016, Plant biotechnology journal.
[6] George M. Church,et al. Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 , 2013, Nature Biotechnology.
[7] N. Smargiasso,et al. Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans , 2017, Front. Plant Sci..
[8] J. Doudna,et al. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , 2012, Science.
[9] R. Hoess,et al. Bacteriophage P 1 Site-specific Recombination , 2001 .
[10] S. Marillonnet,et al. Magnifection--a new platform for expressing recombinant vaccines in plants. , 2005, Vaccine.
[11] L. Vézina,et al. Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines. , 2014, Vaccine.
[12] P. Rudd,et al. Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story , 2017, PloS one.
[13] R. Dwek,et al. Function and glycosylation of plant-derived antiviral monoclonal antibody , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[14] V. Orbović,et al. Modification of the PthA4 effector binding elements in Type I CsLOB1 promoter using Cas9/sgRNA to produce transgenic Duncan grapefruit alleviating XccΔpthA4:dCsLOB1.3 infection. , 2016, Plant biotechnology journal.
[15] D. Aviezer,et al. Glycosylation and functionality of recombinant glucocerebrosidase from various production systems , 2014 .
[16] Detlef Weigel,et al. Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease , 2013, Nature Biotechnology.
[17] Per Capita,et al. About the authors , 1995, Machine Vision and Applications.
[18] Erin L. Doyle,et al. Targeting DNA Double-Strand Breaks with TAL Effector Nucleases , 2010, Genetics.
[19] David Passmore,et al. Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor , 2006, Nature Biotechnology.
[20] Lukas A. Mueller,et al. The Sol Genomics Network (SGN)—from genotype to phenotype to breeding , 2014, Nucleic Acids Res..
[21] L. Presta,et al. Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity* , 2002, The Journal of Biological Chemistry.
[22] Yoram Tekoah,et al. Large-scale production of pharmaceutical proteins in plant cell culture-the Protalix experience. , 2015, Plant biotechnology journal.
[23] R. Dwek,et al. N-glycosylation and the production of recombinant glycoproteins , 1989 .
[24] S. Schillberg,et al. Application of a Scalable Plant Transient Gene Expression Platform for Malaria Vaccine Development , 2015, Front. Plant Sci..
[25] G. Lomonossoff,et al. pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. , 2009, Plant biotechnology journal.
[26] J. Scheller,et al. Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants. , 2008, Plant biotechnology journal.
[27] Zhanguo Xin,et al. High-throughput DNA extraction method suitable for PCR. , 2003, BioTechniques.
[28] R. Hellens,et al. The extremophile Nicotiana benthamiana has traded viral defence for early vigour , 2015, Nature Plants.
[29] Yoram Tekoah,et al. Plant specific N-glycans do not have proven adverse effects in humans , 2016, Nature Biotechnology.
[30] M. Menossi,et al. Heating Greatly Speeds Coomassie Blue Staining and Destaining , 2022 .
[31] J. Perrine. As Plants , 2018 .
[32] G. Grabowski,et al. Taliglucerase alfa: an enzyme replacement therapy using plant cell expression technology. , 2014, Molecular genetics and metabolism.
[33] Kabin Xie,et al. Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system , 2015, Proceedings of the National Academy of Sciences.
[34] Xuecheng Wang,et al. Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation , 2015, Genome Biology.
[35] Jin-Soo Kim,et al. Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases , 2014, Genome research.
[36] N. Sternberg,et al. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. , 1981, Journal of molecular biology.
[37] O. Bohorov,et al. Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody , 2011, PloS one.
[38] T. Hackl,et al. Glycan modulation and sulfoengineering of anti–HIV-1 monoclonal antibody PG9 in plants , 2015, Proceedings of the National Academy of Sciences.
[39] N. Bohorova,et al. Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant , 2011, Proceedings of the National Academy of Sciences.
[40] R. Reski,et al. Glyco-engineering of moss lacking plant-specific sugar residues. , 2005, Plant biology.
[41] G. Stiegler,et al. Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure. , 2008, Plant biotechnology journal.
[42] Yang Lei,et al. CRISPR-P: a web tool for synthetic single-guide RNA design of CRISPR-system in plants. , 2014, Molecular plant.
[43] Yoram Tekoah,et al. Establishment of a tobacco BY2 cell line devoid of plant‐specific xylose and fucose as a platform for the production of biotherapeutic proteins , 2017, Plant biotechnology journal.
[44] T. Mor,et al. Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story , 2015, Biotechnology Letters.
[45] F. Altmann,et al. N-Glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1. , 2000, Analytical biochemistry.
[46] Daniel F Voytas,et al. Multiplexed, targeted gene editing in Nicotiana benthamiana for glyco-engineering and monoclonal antibody production. , 2016, Plant biotechnology journal.
[47] R. Kunert,et al. Production of a monoclonal antibody in plants with a humanized N-glycosylation pattern. , 2007, Plant biotechnology journal.
[48] Aureliano Bombarely,et al. A draft genome sequence of Nicotiana benthamiana to enhance molecular plant-microbe biology research. , 2012, Molecular plant-microbe interactions : MPMI.
[49] W F Thompson,et al. Nuclear scaffolds and scaffold-attachment regions in higher plants. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[50] Renate Kunert,et al. In Planta Protein Sialylation through Overexpression of the Respective Mammalian Pathway , 2010, The Journal of Biological Chemistry.
[51] D. Wallach,et al. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. , 1971, Biochemistry.
[52] A. Trkola,et al. Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1 , 1996, Journal of virology.
[53] A. Regev,et al. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System , 2015, Cell.
[54] R. Fischer,et al. Overcoming low yields of plant‐made antibodies by a protein engineering approach , 2016, Biotechnology journal.
[55] Carl T. Wittwer,et al. uAnalyze: Web-Based High-Resolution DNA Melting Analysis with Comparison to Thermodynamic Predictions , 2012, IEEE/ACM Transactions on Computational Biology and Bioinformatics.
[56] A. Hiatt,et al. Production of antibodies in transgenic plants , 1989, Nature.
[57] R. Knegtel,et al. Mutation of amino acids in the alpha 1,3-fucosyltransferase motif affects enzyme activity and Km for donor and acceptor substrates. , 2004, Glycobiology.
[58] H. Steinkellner,et al. Plant glyco-biotechnology on the way to synthetic biology , 2014, Front. Plant Sci..
[59] M. Schmid,et al. Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana , 2003, Science.
[60] Yoram Tekoah,et al. Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems , 2013, Bioscience reports.
[61] P. Lerouge,et al. Down-regulated expression of plant-specific glycoepitopes in alfalfa. , 2008, Plant biotechnology journal.
[62] Rainer Fischer,et al. The increasing value of plant-made proteins. , 2015, Current opinion in biotechnology.
[63] P. Lerouge,et al. N-Glycoprotein biosynthesis in plants: recent developments and future trends , 1998, Plant Molecular Biology.
[64] S Chandrasegaran,et al. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[65] J. Bardwell,et al. Heating greatly speeds Coomassie blue staining and destaining. , 2000, BioTechniques.
[66] B. van Steensel,et al. Easy quantitative assessment of genome editing by sequence trace decomposition , 2014, Nucleic acids research.
[67] Carole Plasson,et al. Plant-specific glycosylation patterns in the context of therapeutic protein production. , 2010, Plant biotechnology journal.
[68] H. Steinkellner,et al. Generation of Arabidopsis thaliana plants with complex N‐glycans lacking β1,2‐linked xylose and core α1,3‐linked fucose , 2004 .
[69] H. Katinger,et al. Functional analysis of the broadly neutralizing human anti‐HIV‐1 antibody 2F5 produced in transgenic BY‐2 suspension cultures , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[70] F. Bai,et al. Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity. , 2016, The Journal of general virology.