An Efficient Synthesis of 4‐Naphthylpyrimidin‐2‐amine Derivatives under Solvent‐Free Conditions

A simple, efficient, and mild protocol for the synthesis of 4-naphthylpyrimidin-2-amine derivatives under solvent-free conditions by the reaction of aromatic aldehydes (or 1-naphthaldehyde), 2-acetylnaphthalene (or aromatic ketones), guanidine carbonate, and sodium hydroxide was reported. The advantages of this protocol include short reaction time, mild reaction conditions, easy workup, high yields, and environmental friendliness.

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