Individualized treatment for a case of recurrent ovarian ependymoma

Ovarian anaplastic ependymoma is a rare gynecologic malignancy. Owing to its rarity, treatment is challenging. Unilateral ovarian ependymoma was found during laparoscopy in a 19-year-old woman. After cytoreductive surgery, three cycles of bleomycin, etoposide, and cisplatin were administered. Four years after chemotherapy, the patient experienced relapse. After the secondary cytoreductive surgery, no further treatment was performed. She is in good condition, ~19 months after secondary cytoreductive surgery using hormone-replacement therapy without chemotherapy. Some cases of ovarian ependymoma can be treated with surgery alone without chemotherapy and the outcome has been satisfying. Choosing treatment based on malignant ovarian germ cell tumors may be not optimal. Therefore, we suggest individualized treatment for ovarian ependymoma.

[1]  A. Jazaeri,et al.  Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole , 2017, Gynecologic oncology reports.

[2]  Yusuke Kobayashi,et al.  Complete response to paclitaxel, ifosfamide, and cisplatin therapy in a case of ovarian ependymoma , 2016, The journal of obstetrics and gynaecology research.

[3]  G. Fuller,et al.  Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases , 2016, The American journal of surgical pathology.

[4]  M. Rosenblum,et al.  Pelvic Ependymoma With Clinical Response to GnRH Analog Therapy: A Case Report With an Overview of Primary Extraneural Ependymomas. , 2015, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[5]  F. Nogales,et al.  Treatment of Ovarian Anaplastic Ependymoma by an Aromatase Inhibitor , 2014, Obstetrics and gynecology.

[6]  A. Pines,et al.  Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health , 2011, Climacteric : the journal of the International Menopause Society.

[7]  S. Stolnicu,et al.  Ovarian ependymomas of extra-axial type or central immunophenotypes. , 2011, Human pathology.

[8]  M. Souweidane,et al.  Recurrent ependymoma treated with high‐dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary–ovarian axis , 2007, Pediatric blood & cancer.

[9]  P. Disaia,et al.  Malignant Germ Cell Tumors of the Ovary , 2000, Obstetrics and gynecology.

[10]  R. Auerbach,et al.  ESTROGEN AND PROGESTIN RECEPTORS IN AN OVARIAN EPENDYMOMA , 1988, Obstetrics and gynecology.

[11]  R. Giuffrè,et al.  Hormones and tumours in central nervous system (CNS): steroid receptors in primary spinal cord tumours. , 1984, Neurological research.

[12]  R. Scully,et al.  Malignant neuroectodermal tumor of the ovary, a distinctive form of monodermal teratoma: Report of five cases , 1982, The American journal of surgical pathology.

[13]  V. García-Barriola,et al.  Ovarian ependymoma. A case report. , 2000, Pathology, research and practice.

[14]  D. Goldsher,et al.  Clinical and radiographic response in three children with recurrent malignant cerebral tumors with high-dose tamoxifen. , 1999, Pediatric hematology and oncology.