Visualizing Cortical Activation during Mental Calculation with Functional MRI

Cortical activation during arithmetic calculation (silent subtraction by sevens) was compared to that observed during a control condition for which subjects were required to count forward by ones. Nine normal subjects underwent 1.5-T functional magnetic resonance imaging while performing these tasks. All subjects showed bilateral premotor, posterior parietal, and prefrontal cortex activation during serial calculation. There was a large degree of individual variation in activation outside of these areas. These results confirm the role of posterior parietal cortex in arithmetic calculation and implicate other regions, including prefrontal cortex.

[1]  S. E. Henschen.  Klinische und anatomische Beiträge zur Pathologie des Gehirns , 1922 .

[2]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[3]  A. M. Hasofer.  Upcrossings of Random Fields , 1978 .

[4]  Domenico Passafiume,et al.  Calculation Disturbances in Adults with Focal Hemispheric Damage , 1982, Cortex.

[5]  R. Adler,et al.  The Geometry of Random Fields , 1982 .

[6]  E K Warrington,et al.  The Fractionation of Arithmetical Skills: A Single Case Study , 1982, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[7]  G. Radda,et al.  Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. , 1982, Biochimica et biophysica acta.

[8]  P E Roland,et al.  Localization of cortical areas activated by thinking. , 1985, Journal of neurophysiology.

[9]  Alfonso Caramazza,et al.  Cognitive mechanisms in number processing and calculation: Evidence from dyscalculia , 1985, Brain and Cognition.

[10]  Jamie I. D. Campbell,et al.  An encoding-complex view of cognitive number processing: Comment on McCloskey, Sokol, and Goodman (1986). , 1988 .

[11]  P. Goldman-Rakic.  Topography of cognition: parallel distributed networks in primate association cortex. , 1988, Annual review of neuroscience.

[12]  M. Posner,et al.  Positron Emission Tomographic Studies of the Processing of Singe Words , 1989, Journal of Cognitive Neuroscience.

[13]  Harry A. Whitaker,et al.  Acalculia: An historical review of localization , 1991, Brain and Cognition.

[14]  Karl J. Friston,et al.  Distribution of cortical neural networks involved in word comprehension and word retrieval. , 1991, Brain : a journal of neurology.

[15]  Karl J. Friston,et al.  A PET study of word finding , 1991, Neuropsychologia.

[16]  Michael McCloskey,et al.  Facts, rules and procedures in normal calculation: Evidence from multiple single-patient studies of impaired arithmetic fact retrieval , 1991, Brain and Cognition.

[17]  R. Turner,et al.  Echo-planar imaging: magnetic resonance imaging in a fraction of a second. , 1991, Science.

[18]  R. Turner,et al.  Echo‐planar time course MRI of cat brain oxygenation changes , 1991, Magnetic resonance in medicine.

[19]  Alan C. Evans,et al.  A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[20]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[21]  M. Ashcraft.  Cognitive arithmetic: A review of data and theory , 1992, Cognition.

[22]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[23]  W. Bank.  The Human Brain. Surface, Three-Dimensional Sectional Anatomy and MRI , 1993 .

[24]  K Ugurbil,et al.  Functional magnetic resonance imaging of Broca's area during internal speech. , 1993, Neuroreport.

[25]  J B Poline,et al.  Analysis of Individual Positron Emission Tomography Activation Maps by Detection of High Signal-to-Noise-Ratio Pixel Clusters , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  B. Rosen,et al.  Microscopic susceptibility variation and transverse relaxation: Theory and experiment , 1994, Magnetic resonance in medicine.

[27]  Karl J. Friston,et al.  Assessing the significance of focal activations using their spatial extent , 1994, Human brain mapping.

[28]  川島 隆太.  First International Conference on Functional Mapping of the Human Brain , 1994 .

[29]  R. Turner,et al.  MRI Functional activation of left frontal cortex during covert word production , 1994 .

[30]  Karl J. Friston,et al.  Analysis of functional MRI time‐series , 1994, Human Brain Mapping.

[31]  B. J. Casey,et al.  Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI , 1994, Human brain mapping.

[32]  Functional magnetic resonance imaging (F-MRI): basic principles and applications in neuropsychology , 1996 .

[33]  N Lange.  Statistical approaches to human brain mapping by functional magnetic resonance imaging. , 1996, Statistics in medicine.