This article studies the adaptive backstepping control problem for a class of fractional-order (FO) nonlinear systems subject to input quantization and unknown control directions by combining with an indirect FO Lyapunov stability method, and a command filter-based FO dynamic surface control (FODSC) technique. First, a modified FODSC method is utilized to reduce the computational complexity existing in the conventional recursive procedure in which an FO command filter is designed to obtain the command signals and their FO derivatives. Furthermore, the Nussbaum function and neuro-fuzzy networks (NFNs) are adopted to deal with the problem of the unknown control directions and unknown nonlinear functions existing in the system. Moreover, by introducing the compensation and prediction mechanism to controller design, the adaptive controllers, and adaptive laws are constructed to ensure that all the signals of the controlled systems are bounded. Finally, two examples are given to show the validity of the developed control method.