Regulatory role of E3 ubiquitin ligases in normal B lymphopoiesis and B-cell malignancies.

[1]  Li Yang,et al.  E3 ubiquitin ligase neural precursor cell‐expressed developmentally downregulated gene 4 motivates FOXA1 ubiquitination and restrains proliferation of diffuse large B‐cell lymphoma cells via the Wnt/β‐Catenin pathway , 2023, Cell biology international.

[2]  R. Bonasio,et al.  DLBCL associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemo-resistance. , 2023, Blood.

[3]  M. Kreft,et al.  Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation , 2023, Frontiers in Immunology.

[4]  Jeong-Ok Lee,et al.  Bcl-6-dependent risk stratification by nuclear expression of Peli1 in diffuse large B-cell lymphoma , 2022, Journal of Cancer.

[5]  Wei Yang,et al.  Aberrant SPOP-CHAF1A ubiquitination axis triggers tumor autophagy that endows a therapeutical vulnerability in diffuse large B cell lymphoma , 2022, Journal of translational medicine.

[6]  Zhengsheng Wu,et al.  LncRNA FIRRE stimulates PTBP1‐induced Smurf2 decay, stabilizes B‐cell receptor, and promotes the development of diffuse large B‐cell lymphoma , 2022, Hematological oncology.

[7]  M. Safa,et al.  Inhibition of Skp2 enhances doxorubicin‐induced cell death in B cell precursor acute lymphoblastic leukemia , 2022, Cell biology international.

[8]  R. Gartenhaus,et al.  PARK2 regulates eIF4B-driven lymphomagenesis. , 2022, Molecular cancer research : MCR.

[9]  M. Renna,et al.  IBtkα Activates the β-Catenin-Dependent Transcription of MYC through Ubiquitylation and Proteasomal Degradation of GSK3β in Cancerous B Cells , 2022, International journal of molecular sciences.

[10]  Michael L. Wang,et al.  Epstein Barr virus–positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo , 2021, Blood advances.

[11]  L. Staudt,et al.  Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma. , 2021, Blood advances.

[12]  Lunquan Sun,et al.  Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration , 2021, Journal of immunology research.

[13]  C. Fontanillo,et al.  Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen. , 2021, Blood advances.

[14]  R. Kuiper,et al.  Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma , 2021, Familial Cancer.

[15]  Zhenyu Li,et al.  Fbw7 Inhibits the Progression of Activated B-Cell Like Diffuse Large B-Cell Lymphoma by Targeting the Positive Feedback Loop of the LDHA/lactate/miR-223 Axis , 2020, Frontiers in Oncology.

[16]  Xu Wang,et al.  MYD88 L265P Elicits Mutation-specific Ubiquitination to Drive NF-κB Activation and Lymphomagenesis. , 2020, Blood.

[17]  C. Goodnow,et al.  Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice , 2020, bioRxiv.

[18]  K. Elenitoba-Johnson,et al.  FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells , 2020, Cancer Research.

[19]  Michael R. Green,et al.  E3 Ligase, UBR5, HECT domain mutations in lymphoma control maturation of B cells. , 2020, Blood.

[20]  L. Staudt,et al.  Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14 , 2020, Proceedings of the National Academy of Sciences.

[21]  Jie Zhu,et al.  CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling , 2019, Leukemia.

[22]  Qiaojun He,et al.  Kelch-like proteins: physiological functions and relationships with diseases. , 2019, Pharmacological research.

[23]  J. Gribben,et al.  Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation , 2019, Cell reports.

[24]  Yan Li,et al.  The E3 ubiquitin ligase Itch is required for B-cell development , 2019, Scientific Reports.

[25]  J. Doench,et al.  CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation , 2019, Cell reports.

[26]  Bochra Zidi,et al.  TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling , 2018, Proceedings of the National Academy of Sciences.

[27]  H. Eibel,et al.  BAFF and BAFF-Receptor in B Cell Selection and Survival , 2018, Front. Immunol..

[28]  Kou-Juey Wu,et al.  Ubiquitination by HUWE1 in tumorigenesis and beyond , 2018, Journal of Biomedical Science.

[29]  Yaofeng Zhao,et al.  Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development , 2018, International immunology.

[30]  Jianxun Song,et al.  The endoplasmic reticulum–resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice , 2018, The Journal of Biological Chemistry.

[31]  K. Young,et al.  MYD88 L265P Mutation in Lymphoid Malignancies. , 2018, Cancer research.

[32]  Michael R. Green,et al.  Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor Roquin2 , 2018, Nature Cell Biology.

[33]  M. Mallardo,et al.  The expression of inhibitor of bruton’s tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis , 2018, Cell Death & Disease.

[34]  B. Bertocci,et al.  Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation , 2017, The Journal of Immunology.

[35]  D. Vaux,et al.  Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. , 2017, The Journal of Biological Chemistry.

[36]  Su Yao,et al.  Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation , 2017, Journal of Experimental & Clinical Cancer Research.

[37]  S. Miyamoto,et al.  FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma , 2016, Oncogene.

[38]  Sohee Oh,et al.  PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma , 2016, Modern Pathology.

[39]  E. Wolf,et al.  The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment , 2016, Nature immunology.

[40]  K. Basso,et al.  FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. , 2016, Blood.

[41]  C. K. Watts,et al.  Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer , 2015, Molecular Cancer Research.

[42]  L. Staudt,et al.  B-cell receptor signaling in diffuse large B-cell lymphoma. , 2015, Seminars in hematology.

[43]  L. Staudt,et al.  Protein ubiquitination in lymphoid malignancies , 2015, Immunological reviews.

[44]  Ji-Eun Kim,et al.  Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. , 2014, The Journal of clinical investigation.

[45]  V. Pant,et al.  Limiting the power of p53 through the ubiquitin proteasome pathway , 2014, Genes & development.

[46]  Rudolf Grosschedl,et al.  The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function , 2014, Immunological reviews.

[47]  K. Tarte,et al.  A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells. , 2014, Blood.

[48]  K. Iwai,et al.  Mechanism Underlying IκB Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex , 2014, Molecular and Cellular Biology.

[49]  P. Moynagh.  The roles of Pellino E3 ubiquitin ligases in immunity , 2014, Nature Reviews Immunology.

[50]  W. Gu,et al.  Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC. , 2013, Leukemia research.

[51]  Charusheila Ramkumar,et al.  Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1 , 2013, Nature Communications.

[52]  Xiao-Ming Yin,et al.  The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation , 2013, Autophagy.

[53]  Bodo Grimbacher,et al.  B-cell biology and development. , 2013, The Journal of allergy and clinical immunology.

[54]  L. Staudt,et al.  Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma , 2013, Proceedings of the National Academy of Sciences.

[55]  Christian Langer,et al.  SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma , 2012, Nature Cell Biology.

[56]  P. Fox,et al.  Pellino 2 Is critical for Toll-like Receptor/Interleukin-1 Receptor (TLR/IL-1R)-mediated Post-transcriptional Control* , 2012, The Journal of Biological Chemistry.

[57]  Charusheila Ramkumar,et al.  Smurf2 regulates the senescence response and suppresses tumorigenesis in mice. , 2012, Cancer research.

[58]  C. Paige,et al.  The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation. , 2012, Seminars in immunology.

[59]  Bill B. Chen,et al.  F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. , 2012, Blood.

[60]  L. Staudt,et al.  Pathogenesis of human B cell lymphomas. , 2012, Annual review of immunology.

[61]  A. Hoffmann,et al.  Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma , 2012, Nature Cell Biology.

[62]  T. Mak,et al.  The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis , 2012, The Journal of experimental medicine.

[63]  Michele Pagano,et al.  FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas , 2012, Nature.

[64]  Yi Tang,et al.  A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20 , 2011, Nature Medicine.

[65]  W. Guo,et al.  Genome‐wide copy number analyses identified novel cancer genes in hepatocellular carcinoma , 2011, Hepatology.

[66]  Anthony W. Purcell,et al.  Linear ubiquitination prevents inflammation and regulates immune signalling , 2011, Nature.

[67]  A. Ma,et al.  Ubiquitin makes its mark on immune regulation. , 2010, Immunity.

[68]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[69]  K. Okkenhaug,et al.  The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development , 2010, Science Signaling.

[70]  J. Lötvall,et al.  B Cells: From Early Development to Regulating Allergic Diseases , 2010, Archivum Immunologiae et Therapiae Experimentalis.

[71]  A. Strasser,et al.  Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development , 2010, Nature Immunology.

[72]  G. D. Gatta,et al.  Hematopoietic Stem Cell Differentiation Regulated by a Single Ubiquitin Ligase: Substrate Complex , 2009, Nature Immunology.

[73]  D. Rotin,et al.  Physiological functions of the HECT family of ubiquitin ligases , 2009, Nature Reviews Molecular Cell Biology.

[74]  M. Reth,et al.  Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling , 2009, Nature Reviews Immunology.

[75]  S. Akira,et al.  Involvement of linear polyubiquitylation of NEMO in NF-κB activation , 2009, Nature Cell Biology.

[76]  Carl W. Miller,et al.  FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. , 2008, Leukemia research.

[77]  R. DePinho,et al.  Distinct roles for Foxo1 at multiple stages of B cell differentiation , 2008, Nature Immunology.

[78]  Linheng Li,et al.  Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. , 2008, Genes & development.

[79]  T. Yamazaki,et al.  Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. , 2008, Blood.

[80]  L. Hendershot,et al.  Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. , 2007, Molecular cell.

[81]  P. Moynagh,et al.  Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family , 2007, Journal of Biological Chemistry.

[82]  R. Hardy,et al.  Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. , 2007, Immunity.

[83]  M. Busslinger,et al.  Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5 , 2006, Molecular and Cellular Biology.

[84]  Gabriel Pons,et al.  MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. , 2006, Blood.

[85]  P. Sicinski,et al.  A unique function for cyclin D3 in early B cell development , 2006, Nature Immunology.

[86]  Claudia Waskow,et al.  The BTB-kelch Protein KLHL6 Is Involved in B-Lymphocyte Antigen Receptor Signaling and Germinal Center Formation , 2005, Molecular and Cellular Biology.

[87]  Jun Qin,et al.  ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor , 2005, Cell.

[88]  U. Siebenlist,et al.  Control of lymphocyte development by nuclear factor-κB , 2005, Nature Reviews Immunology.

[89]  E. Lam,et al.  Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells , 2005, Oncogene.

[90]  C. Elly,et al.  Differential Regulation of the B Cell Receptor-mediated Signaling by the E3 Ubiquitin Ligase Cbl* , 2004, Journal of Biological Chemistry.

[91]  C. Mackay,et al.  B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells1 , 2004, The Journal of Immunology.

[92]  H. Young,et al.  Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members , 2004, Molecular and Cellular Biology.

[93]  A. Kudo,et al.  EBF‐regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells , 2003, European journal of immunology.

[94]  T. Greiner,et al.  Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis , 2003, The EMBO journal.

[95]  J. Weill,et al.  Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. , 2003, Molecular immunology.

[96]  A. Sánchez-Aguilera,et al.  Cell cycle deregulation in B-cell lymphomas. , 2003, Blood.

[97]  J. Ihle,et al.  Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex , 2002, Molecular and Cellular Biology.

[98]  E. Vigorito,et al.  A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation , 2002, The Journal of experimental medicine.

[99]  R. Gerstein,et al.  The Earliest Step in B Lineage Differentiation from Common Lymphoid Progenitors Is Critically Dependent upon Interleukin 7 , 2002, The Journal of experimental medicine.

[100]  Yun-Cai Liu,et al.  Cbl and Cbl-b in T-cell regulation. , 2002, Trends in immunology.

[101]  H. Fleming,et al.  Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. , 2001, Immunity.

[102]  W. Langdon,et al.  Cbl: many adaptations to regulate protein tyrosine kinases , 2001, Nature Reviews Molecular Cell Biology.

[103]  M. Roussel,et al.  Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. , 1999, Genes & development.

[104]  F. Alt,et al.  Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. , 1999, Science.

[105]  A. Israël,et al.  Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha. , 1997, The Journal of biological chemistry.

[106]  T. Kinoshita,et al.  The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. , 1994, Blood.

[107]  Hai Qi,et al.  External signals regulate germinal center fate‐determining transcription factors in the A20 lymphoma cell line , 2018, Molecular immunology.