Diter von Wettstein, Professor of Genetics and Master of Translating Science into Applications.

The present and subsequent chapters in this volume are dedicated to the life and research of Professor Diter von Wettstein who contributed immensely to the development of science and education. His contributions spanned various fields of science such as genetics, physiology, ultrastructural analysis, molecular biology, genomics, and biotechnology including genome editing. He performed and promoted pioneering research in the fields of epigenetics, directed evolution of enzymes, synthetic biology (promoter and gene optimizations), and genomics (genome sequencing of baker's yeast). Glimpses of his time at the Carlsberg Laboratory and Washington State University, with examples from the research performed at these institutions, are included in this chapter. His life is an inspiration to the next generation of biologists. Despite difficult situations, his persistent efforts and keen desire to learn enabled him to overcome obstacles. He always tried to attain the best, excelling in translating fundamental knowledge into applications.

[1]  K. K. Thomsen,et al.  Hybrid bacillus endo-(1–3, 1–4)-β-glucanases: Construction of recombinant genes and molecular properties of the gene products , 1989, Carlsberg research communications.

[2]  D. von Wettstein,et al.  Supplements of transgenic malt or grain containing (1,3-1,4)-ß-glucanase increase the nutritive value of barley-based broiler diets to that of maize , 2003, British poultry science.

[3]  C. Konzak,et al.  Generation of Doubled Haploid Transgenic Wheat Lines by Microspore Transformation , 2013, PloS one.

[4]  R. Brueggeman,et al.  Genetically engineered stem rust resistance in barley using the Rpg1 gene , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Wettstein.  Fascination with Chloroplasts and Chromosome Pairing , 2006 .

[6]  K. Murphy,et al.  Assessment of Genetic Diversity among Barley Cultivars and Breeding Lines Adapted to the US Pacific Northwest, and Its Implications in Breeding Barley for Imidazolinone-Resistance , 2014, PloS one.

[7]  Bao Liu,et al.  Structural genes of wheat and barley 5-methylcytosine DNA glycosylases and their potential applications for human health , 2012, Proceedings of the National Academy of Sciences.

[8]  G. Mikhaylenko,et al.  Improved barley broiler feed with transgenic malt containing heat-stable (1,3-1,4)-beta-glucanase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Hoober.  Diter von Wettstein (Dietrich Holger Wettstein Ritter von Westersheim): September 20, 1929-April 13, 2017 , 2017, Photosynthesis Research.

[10]  K. K. Thomsen,et al.  Transgenic barley expressing a protein-engineered, thermostable (1,3-1,4)-beta-glucanase during germination. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[11]  C. Osorio.  Development of transgenic barley expressing human type I collagen , 2004 .

[12]  D. von Wettstein,et al.  Growth inhibition of the cereal root pathogens Rhizoctonia solani AG8, R. oryzae and Gaeumannomyces graminis var. tritici by a recombinant 42-kDa endochitinase from Trichoderma harzianum , 2006 .

[13]  Karl-Heinz Kogel,et al.  Transcriptome and metabolome profiling of field-grown transgenic barley lack induced differences but show cultivar-specific variances , 2010, Proceedings of the National Academy of Sciences.

[14]  K. K. Thomsen,et al.  Inheritance of a Codon‐Optimized Transgene Expressing Heat Stable (1,3‐1,4)‐β‐Glucanase in Scutellum and Aleurone of Germinating Barley , 2004 .

[15]  T. Okita,et al.  The production of recombinant proteins in transgenic barley grains. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[16]  S. Ullrich,et al.  Single nucleotide mutation in the barley acetohydroxy acid synthase (AHAS) gene confers resistance to imidazolinone herbicides , 2011, Proceedings of the National Academy of Sciences.

[17]  Diter von Wettstein,et al.  From Analysis of Mutants to Genetic Engineering , 2007 .

[18]  D. von Wettstein,et al.  T-DNA integration into the barley genome from single and double cassette vectors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  D. Wettstein,et al.  Registration of ‘Radiant’ Barley , 2004 .

[20]  Bao Liu,et al.  Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac disease , 2018, Functional & Integrative Genomics.