Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice

[1]  M. Herkenham,et al.  CCR2 monocytes repair cerebrovascular damage caused by chronic social defeat stress , 2022, Brain, Behavior, and Immunity.

[2]  Yu-Qiang Ding,et al.  Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines , 2021, Neuron.

[3]  Juan Daniel Flórez Weidinger,et al.  Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation , 2021, Nature Neuroscience.

[4]  M. Weissman,et al.  Dorsolateral Prefrontal Cortex and Subcallosal Cingulate Connectivity Show Preferential Antidepressant Response in Major Depressive Disorder. , 2020, Biological psychiatry. Cognitive neuroscience and neuroimaging.

[5]  M. Horchar,et al.  Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress , 2020, Neuropsychopharmacology.

[6]  D. Reich,et al.  Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease , 2019, bioRxiv.

[7]  M. Horchar,et al.  Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress , 2019, Brain, Behavior, and Immunity.

[8]  R. Horton,et al.  Reducing the global burden of depression: a Lancet–World Psychiatric Association Commission , 2019, The Lancet.

[9]  Ninon Burgos,et al.  New advances in the Clinica software platform for clinical neuroimaging studies , 2019 .

[10]  Mitchell H. Murdock,et al.  Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation , 2019, Science.

[11]  Dustin Scheinost,et al.  Lower synaptic density is associated with depression severity and network alterations , 2019, Nature Communications.

[12]  Jian-Guo Chen,et al.  SAR405, a Highly Specific VPS34 Inhibitor, Disrupts Auditory Fear Memory Consolidation of Mice via Facilitation of Inhibitory Neurotransmission in Basolateral Amygdala , 2019, Biological Psychiatry.

[13]  G. D. Liberto,et al.  Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping , 2018, Cell.

[14]  D. Lewis,et al.  Opposite Molecular Signatures of Depression in Men and Women , 2018, Biological Psychiatry.

[15]  B. Baban,et al.  Complement component 3a receptor deficiency attenuates chronic stress-induced monocyte infiltration and depressive-like behavior , 2018, Brain, Behavior, and Immunity.

[16]  R. Duman,et al.  Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior , 2018, Biological Psychiatry.

[17]  Sophie E. Holmes,et al.  Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder , 2017, Neuropsychopharmacology.

[18]  M. Nomoto,et al.  Microglia may compensate for dopaminergic neuron loss in experimental Parkinsonism through selective elimination of glutamatergic synapses from the subthalamic nucleus , 2017, Glia.

[19]  E. Nestler,et al.  VGF function in depression and antidepressant efficacy , 2017, Molecular Psychiatry.

[20]  Elly Nedivi,et al.  Spine Dynamics: Are They All the Same? , 2017, Neuron.

[21]  Beth Stevens,et al.  Microglia emerge as central players in brain disease , 2017, Nature Medicine.

[22]  Beth Stevens,et al.  Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice , 2017, Science Translational Medicine.

[23]  T. Olender,et al.  Developmental activities of the complement pathway in migrating neurons , 2017, Nature Communications.

[24]  M. Friedrich.  Depression Is the Leading Cause of Disability Around the World. , 2017, JAMA.

[25]  Edmund Wong,et al.  Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder , 2016, Human brain mapping.

[26]  C. Limatola,et al.  Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress , 2016, Brain, Behavior, and Immunity.

[27]  Robert E. Schmidt,et al.  A complement–microglial axis drives synapse loss during virus-induced memory impairment , 2016, Nature.

[28]  Ben A. Barres,et al.  Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.

[29]  Lixin Liu,et al.  Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain , 2016, Journal of Neuroinflammation.

[30]  Shaomin Li,et al.  Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline , 2015, The Journal of Neuroscience.

[31]  F. Baas,et al.  Complement C1q‐C3–associated synaptic changes in multiple sclerosis hippocampus , 2015, Annals of neurology.

[32]  J. Andrews-Hanna,et al.  Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity. , 2015, JAMA psychiatry.

[33]  T. Nabeshima,et al.  Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC , 2015, Neuropsychopharmacology.

[34]  Emily K. Lehrman,et al.  An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. , 2014, Journal of visualized experiments : JoVE.

[35]  Ju Lu,et al.  Spatiotemporal dynamics of dendritic spines in the living brain , 2014, Front. Neuroanat..

[36]  Stephen M. Smith,et al.  Permutation inference for the general linear model , 2014, NeuroImage.

[37]  Guy C. Brown,et al.  Microglial phagocytosis of live neurons , 2014, Nature Reviews Neuroscience.

[38]  Francesco Sforazzini,et al.  Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior , 2014, Nature Neuroscience.

[39]  Nanxin Li,et al.  Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses , 2013, Biological Psychiatry.

[40]  M. Nilsson,et al.  Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function , 2013, Current drug targets.

[41]  M. Bennett,et al.  Stress-Induced Grey Matter Loss Determined by MRI Is Primarily Due to Loss of Dendrites and Their Synapses , 2013, Molecular Neurobiology.

[42]  G. Aghajanian,et al.  Synaptic Dysfunction in Depression: Potential Therapeutic Targets , 2012, Science.

[43]  G. Rajkowska,et al.  Decreased Expression of Synapse-Related Genes and Loss of Synapses in Major Depressive Disorder , 2012, Nature Medicine.

[44]  Ben A. Barres,et al.  Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner , 2012, Neuron.

[45]  John W. Thatcher,et al.  Aberrant functional connectivity of cortico-basal ganglia circuits in major depression , 2012, Neuroscience Letters.

[46]  S. Russo,et al.  A standardized protocol for repeated social defeat stress in mice , 2011, Nature Protocols.

[47]  Arno Klein,et al.  A reproducible evaluation of ANTs similarity metric performance in brain image registration , 2011, NeuroImage.

[48]  Nanxin Li,et al.  mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists , 2010, Science.

[49]  W. Drevets,et al.  Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide , 2009, Neuroscience & Biobehavioral Reviews.

[50]  Glenda M. MacQueen,et al.  Posterior Hippocampal Volumes Are Associated with Remission Rates in Patients with Major Depressive Disorder , 2008, Biological Psychiatry.

[51]  G. Aghajanian,et al.  Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy , 2008, Proceedings of the National Academy of Sciences.

[52]  John D. Lambris,et al.  The Classical Complement Cascade Mediates CNS Synapse Elimination , 2007, Cell.

[53]  Scott J. Russo,et al.  Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions , 2007, Cell.

[54]  W. Gan,et al.  Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex , 2007, Nature Neuroscience.

[55]  Tobias M. Rasse,et al.  Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses , 2007, Nature Protocols.

[56]  M. Sheng,et al.  Dentritic spines : structure, dynamics and regulation , 2001, Nature Reviews Neuroscience.

[57]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[58]  P. Butko,et al.  Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.