Evolution: Revenge of the hopeful monster

Experiments have revealed how single mutations can have huge effects that drive evolution. But small steps pave the way, finds Tanguy Chouard.

[1]  Richard E. Lenski,et al.  Mechanisms Causing Rapid and Parallel Losses of Ribose Catabolism in Evolving Populations of Escherichia coli B , 2001, Journal of bacteriology.

[2]  H. A. Orr,et al.  The genetic theory of adaptation: a brief history , 2005, Nature Reviews Genetics.

[3]  Jeremy Schmutz,et al.  Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles , 2005, Science.

[4]  R. Ricklefs,et al.  Darwin's bridge between microevolution and macroevolution , 2009, Nature.

[5]  R. Lenski,et al.  Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli , 2008 .

[6]  D. Schluter,et al.  Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks , 2004, Nature.

[7]  E. Ortlund,et al.  An epistatic ratchet constrains the direction of glucocorticoid receptor evolution , 2009, Nature.

[8]  Alex A. Pollen,et al.  cis-Regulatory Changes in Kit Ligand Expression and Parallel Evolution of Pigmentation in Sticklebacks and Humans , 2007, Cell.

[9]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[10]  Jeremy Schmutz,et al.  Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer , 2010, Science.

[11]  D. Schluter,et al.  The genetic architecture of divergence between threespine stickleback species , 2001, Nature.

[12]  R. Lenski,et al.  Punctuated Evolution Caused by Selection of Rare Beneficial Mutations , 1996, Science.

[13]  Jeffrey E. Barrick,et al.  Genome evolution and adaptation in a long-term experiment with Escherichia coli , 2009, Nature.

[14]  A. Dean,et al.  Mechanistic approaches to the study of evolution: the functional synthesis , 2007, Nature Reviews Genetics.