Chemistry and Pharmacology of Anticancer Drugs

INTRODUCTION TO CANCER Terminology Metastases Diagnosis and Screening Formation of Cancer Cells (Tumorigenesis) Mechanisms of Genomic Damage Treatments Discovery of Anticancer Drugs and Preclinical Evaluation Accessibility of Drugs to Tumor Cells Achieving Selective Toxicity Limiting the Toxicity of Chemotherapeutic Agents Overview of Mechanisms of Action of Chemotherapeutic Agents Drug Resistance Combination Chemotherapy Use of Adjuvants Infertility Following Cancer Treatments ANTIMETABOLITES DHFR Inhibitors (Antifolates) Purine Antimetabolites Pyrimidine Antimetabolites Thymidylate Synthase Inhibition Adenosine Deaminase Inhibition Ribonucleotide Reductase Inhibition DNA-INTERACTIVE AGENTS Alkylating Agents Cross-Linking Agents Intercalating Agents Topoisomerase Inhibitors DNA-Cleaving Agents ANTITUBULIN AGENTS Vinca Alkaloids The Taxanes MOLECULARLY TARGETED AGENTS Kinase Inhibitors Inhibition of Ras Pathway Signaling Cell Cycle Inhibitors Proteasome Inhibitors mTOR Inhibitors HORMONAL THERAPIES Breast Cancer Prostatic Cancer Neuroendocrine Tumors: Somatostatin Analogs Estrogen Therapy Progestogen Therapy TUMOR-TARGETING STRATEGIES Antibody-Based Approaches Vascular-Targeting Strategies X-DEPT (Biphasic) Strategies Enzymatic Targeting Photoactivated Drugs (Photodynamic Therapy) Boron Neutron Capture Therapy Novel Drug Delivery Approaches BIOLOGICAL AGENTS Biological Response Modifiers Immunotherapy Enzyme-Based Therapies Vaccines THE FUTURE Novel Biological Targets and Therapeutic Strategies New Research Tools and Methodologies Chemopreventive Agents PERSONALIZED TREATMENTS Screening for Risk of Disease Development Prognosis and Staging Screening for Risk of Recurrence of Disease Selecting Best Treatments for Patients Predicting Side Effects of Chemotherapeutic Agents Pharmacogenomics in Clinical Trials ADJUNCT THERAPIES Anti-emetic Agents Steroidal Agents Adjuvent Enzymes Other Therapies Index *Each chapter includes an Introduction and a Further Reading section.