Brain imaging: applications in psychiatry

Various brain imaging techniques have become available in the past decade. These include techniques to evaluate brain structure, such as computed tomography and magnetic resonance imaging, and techniques to assess functional activity, such as measurement of regional cerebral blood flow, single photon emission computed tomography, and positron emission tomography. These techniques can be used to map brain structure and function in normal human beings, and they have enlarged our knowledge of the pathophysiology of mental illnesses by demonstrating structural, metabolic, and neurochemical abnormalities in a wide range of mental disorders.

[1]  G. Sedvall,et al.  Imaging of neurotransmitter receptors in the living human brain. , 1986, Archives of general psychiatry.

[2]  R. Mathew,et al.  Regional cerebral blood flow in schizophrenia. , 1982, Archives of general psychiatry.

[3]  N Veall,et al.  The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording. , 1965, Clinical science.

[4]  Jonathan M. Links,et al.  Imaging dopamine receptors in the human brain by positron tomography , 1983 .

[5]  P. Seeman,et al.  Elevation of brain neuroleptic/dopamine receptors in schizophrenia. , 1980, The American journal of psychiatry.

[6]  D. Ingvar,et al.  ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA , 1974, Acta psychiatrica Scandinavica.

[7]  J. Ehrhardt,et al.  Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study. , 1986, Archives of general psychiatry.

[8]  G. Pearlson,et al.  Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. , 1986, Science.

[9]  L. DeLisi,et al.  Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. , 1984, Archives of general psychiatry.

[10]  R. Holloway,,et al.  Sexual dimorphism in the human corpus callosum. , 1982, Science.

[11]  M. Poulter,et al.  INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIA , 1978, The Lancet.

[12]  M D Devous,et al.  SPECT Study of Regional Cerebral Blood Flow in Alzheimer Disease , 1986, Journal of computer assisted tomography.

[13]  S. Snyder,et al.  The dopamine hypothesis of schizophrenia: focus on the dopamine receptor. , 1976, The American journal of psychiatry.

[14]  P. Seeman,et al.  Antipsychotic drug doses and neuroleptic/dopamine receptors , 1976, Nature.

[15]  D. Weinberger,et al.  Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. , 1979, Archives of general psychiatry.

[16]  P Riederer,et al.  Bimodal distribution of dopamine receptor densities in brains of schizophrenics. , 1984, Science.

[17]  J. Kleinman,et al.  Cerebral ventricular enlargement in chronic schizophrenia. An association with poor response to treatment. , 1980, Archives of general psychiatry.

[18]  N C Andreasen,et al.  Negative symptoms in schizophrenia , 1982 .

[19]  F. Benes,et al.  Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. , 1986, Archives of general psychiatry.

[20]  S. Stone-Elander,et al.  No D2 receptor increase in PET study of schizophrenia. , 1987, Archives of general psychiatry.

[21]  D. Weinberger,et al.  Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. , 1986, Archives of general psychiatry.

[22]  J. Mazziotta,et al.  Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. , 1987, Archives of general psychiatry.

[23]  S. Marder,et al.  Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. , 1983, Science.

[24]  S. Mednick,et al.  Cerebral ventricular size in the offspring of schizophrenic mothers. A preliminary study. , 1984, Archives of general psychiatry.

[25]  S H Snyder,et al.  Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs , 1976, Science.

[26]  E Courchesne,et al.  Abnormal neuroanatomy in a nonretarded person with autism. Unusual findings with magnetic resonance imaging. , 1987, Archives of neurology.

[27]  T. Crow,et al.  CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA , 1976, The Lancet.

[28]  W D Obrist,et al.  Sex and handedness differences in cerebral blood flow during rest and cognitive activity. , 1982, Science.

[29]  P. Rakić,et al.  Development of the corpus callosum and cavum septi in man , 1968, The Journal of comparative neurology.

[30]  M. Buchsbaum,et al.  Functional and anatomical brain imaging: impact on schizophrenia research. , 1987, Schizophrenia bulletin.

[31]  T Greitz,et al.  Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[32]  H. Meltzer,et al.  Biological studies in schizophrenia. , 1987, Schizophrenia bulletin.

[33]  L. DeLisi,et al.  Glucose utilization in the temporal cortex of affectively ill patients: Positron emission tomography , 1987, Biological Psychiatry.

[34]  W. Obrist,et al.  Regional cerebral blood flow estimated by 133-xenon inhalation. , 1975, Stroke.

[35]  J. Allman,et al.  Mapping human visual cortex with positron emission tomography , 1986, Nature.

[36]  N. Andreasen,et al.  Ventricular enlargement in schizophrenia: definition and prevalence. , 1982, The American journal of psychiatry.

[37]  A. Alavi,et al.  Regional brain function in schizophrenia. I. A positron emission tomography study. , 1987, Archives of general psychiatry.

[38]  T. Budinger,et al.  External imaging of cerebral muscarinic acetylcholine receptors. , 1984, Science.

[39]  M. Reivich,et al.  Brain function in psychiatric disorders. III. Regional cerebral blood flow in unmedicated schizophrenics. , 1983, Archives of general psychiatry.

[40]  F. Benes,et al.  An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. , 1987, Archives of general psychiatry.

[41]  M S Gazzaniga,et al.  No sex‐related differences in human corpus callosum based on magnetic resonance imagery , 1987, Annals of neurology.

[42]  Andrew Kertesz,et al.  Cerebral Asymmetries on Magnetic Resonance Imaging , 1986, Cortex.

[43]  G. Sedvall,et al.  Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. , 1986, Science.

[44]  R Harrop,et al.  Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease , 1986, Neurology.

[45]  W. Nauta.  The problem of the frontal lobe: a reinterpretation. , 1971, Journal of psychiatric research.

[46]  G. Reynolds.  Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia , 1983, Nature.

[47]  A. Damasio,et al.  Sign language aphasia during left-hemisphere Amytal injection , 1986, Nature.

[48]  J. Risberg,et al.  Hemispheric specialization in normal man studied by bilateral measurements of the regional cerebral blood flow. A study with the 133-Xe inhalation technique. , 1975, Brain : a journal of neurology.

[49]  D. Weinberger,et al.  Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort. , 1986, Archives of general psychiatry.

[50]  B. Bogerts,et al.  Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage , 1985 .

[51]  M. Raichle,et al.  Left globus pallidus abnormality in never-medicated patients with schizophrenia. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[52]  T. Crow,et al.  DOPAMINE D2 RECEPTORS IN SCHIZOPHRENIA STUDIED IN VIVO , 1986, The Lancet.

[53]  H. Thompson,et al.  Determination of Regional Cerebral Blood Flow by Inhalation of 133‐Xenon , 1967, Circulation research.

[54]  R. Hamer,et al.  Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. , 1983, The American journal of psychiatry.

[55]  D. Weinberger,et al.  Lateral cerebral ventricular enlargement in chronic schizophrenia. , 1979, Archives of general psychiatry.

[56]  N C Andreasen,et al.  Negative v positive schizophrenia. Definition and validation. , 1982, Archives of general psychiatry.

[57]  M E Raichle,et al.  The application of positron emission tomography to the study of panic disorder. , 1986, The American journal of psychiatry.