Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy

[1]  M. Altfeld,et al.  Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection , 2020, Nature Communications.

[2]  Lawrence M. Lifshitz,et al.  HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells , 2019, Nature Immunology.

[3]  T. Ndung’u,et al.  Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children , 2019, Front. Immunol..

[4]  R. Fulton,et al.  Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues , 2019, Nature Immunology.

[5]  T. Ndung’u,et al.  Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis , 2019, Nature.

[6]  D. Masopust,et al.  Tissue-Resident T Cells and Other Resident Leukocytes. , 2019, Annual review of immunology.

[7]  T. Ndung’u,et al.  Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children , 2019, The Journal of infectious diseases.

[8]  J. Brenchley,et al.  Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells , 2018, Nature Communications.

[9]  R. Locksley,et al.  Innate Lymphoid Cells: 10 Years On , 2018, Cell.

[10]  Yuntao Xie,et al.  KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing , 2018, Nature.

[11]  R. K. Reeves,et al.  Innate Lymphoid Cells in HIV/SIV Infections , 2017, Front. Immunol..

[12]  C. Wilhelm,et al.  Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue Protection—Linking the Nutritional State to Barrier Immunity , 2017, Front. Immunol..

[13]  Joseph C. Sun,et al.  Innate Lymphoid Cell Immunometabolism. , 2017, Journal of molecular biology.

[14]  B. Jacquelin,et al.  Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys , 2017, Nature Medicine.

[15]  H. Veiga-Fernandes,et al.  HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication , 2017, Mucosal Immunology.

[16]  C. Strassburg,et al.  Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy , 2017, PLoS pathogens.

[17]  L. Lenz,et al.  Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants , 2017, Front. Immunol..

[18]  I. Amit,et al.  Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation , 2017, Cell.

[19]  Jinfang Zhu,et al.  Transcriptional regulators dictate innate lymphoid cell fates , 2017, Protein & Cell.

[20]  B. Walker,et al.  Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection , 2016, Science Translational Medicine.

[21]  G. Silvestri,et al.  What pediatric nonprogressors and natural SIV hosts teach us about HIV , 2016, Science Translational Medicine.

[22]  Amos Tanay,et al.  The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome , 2016, Cell.

[23]  A. Fischer,et al.  Evidence of innate lymphoid cell redundancy in humans , 2016, Nature Immunology.

[24]  G. Aldrovandi,et al.  Maternal HIV infection influences the microbiome of HIV-uninfected infants , 2016, Science Translational Medicine.

[25]  R. Everett,et al.  MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus , 2016, Journal of Virology.

[26]  Olivia I. Koues,et al.  Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells , 2016, Cell.

[27]  R. Mebius,et al.  Innate lymphoid cells in secondary lymphoid organs , 2016, Immunological reviews.

[28]  U. Sauer,et al.  The maternal microbiota drives early postnatal innate immune development , 2016, Science.

[29]  S. Lewin,et al.  Paediatric HIV infection: the potential for cure , 2016, Nature Reviews Immunology.

[30]  P. Goulder,et al.  Immune activation and paediatric HIV-1 disease outcome , 2016, Current opinion in HIV and AIDS.

[31]  B. Walker,et al.  Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. , 2016, Immunity.

[32]  Åsa K. Björklund,et al.  The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing , 2016, Nature Immunology.

[33]  A. Rudensky,et al.  Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs , 2015, Science.

[34]  Zheng Zhang,et al.  Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. , 2015, The Journal of clinical investigation.

[35]  A. Lackner,et al.  Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus‐infected macaques , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  Nicolas Serafini,et al.  Transcriptional regulation of innate lymphoid cell fate , 2015, Nature Reviews Immunology.

[37]  M. Carrington,et al.  Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection , 2015, PLoS pathogens.

[38]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[39]  H. Nelson,et al.  Notch Signaling at Later Stages of NK Cell Development Enhances KIR Expression and Functional Maturation , 2014, The Journal of Immunology.

[40]  B. Blom,et al.  Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. , 2014, Blood.

[41]  P. Goulder,et al.  Immunity to HIV in Early Life , 2014, Front. Immunol..

[42]  M. Bedford,et al.  A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator , 2014, Nucleic acids research.

[43]  S. A. van de Pavert,et al.  Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity , 2014, Nature.

[44]  S. Roff,et al.  The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis , 2014, Front. Immunol..

[45]  S. Jameson,et al.  Transcriptional downregulation of S1pr1 is required for establishment of resident memory CD8+ T cells , 2013, Nature Immunology.

[46]  D. Douek,et al.  Systemic effects of inflammation on health during chronic HIV infection. , 2013, Immunity.

[47]  R. Callard,et al.  Predicting Patterns of Long-Term CD4 Reconstitution in HIV-Infected Children Starting Antiretroviral Therapy in Sub-Saharan Africa: A Cohort-Based Modelling Study , 2013, PLoS medicine.

[48]  C. Buskens,et al.  Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues , 2013, Nature Immunology.

[49]  Eric Vivier,et al.  Innate lymphoid cells — a proposal for uniform nomenclature , 2013, Nature Reviews Immunology.

[50]  S. Rowland-Jones,et al.  The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life , 2012, Front. Immun..

[51]  R. K. Reeves,et al.  Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection , 2012, Front. Immun..

[52]  C. Giaquinto,et al.  Immune reconstitution and vaccination outcome in HIV-1 infected children , 2012, Human vaccines & immunotherapeutics.

[53]  J. Church.  Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-Infected Children: Effects on Long-Term T-Cell Reconstitution , 2012, Pediatrics.

[54]  B. Walker,et al.  HIV and HLA class I: an evolving relationship. , 2012, Immunity.

[55]  P. Klenerman,et al.  The impact of differential antiviral immunity in children and adults , 2012, Nature Reviews Immunology.

[56]  R. Kaul,et al.  A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis , 2012, Mucosal Immunology.

[57]  F. Bushman,et al.  Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria , 2012, Science.

[58]  Y. Belkaid,et al.  Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection , 2012, Mucosal Immunology.

[59]  R. Callard,et al.  Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitution. , 2012, The Journal of infectious diseases.

[60]  R. Johnson,et al.  Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. , 2011, Blood.

[61]  Colin N. Dewey,et al.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.

[62]  P. Ghys,et al.  Net survival of perinatally and postnatally HIV-infected children: a pooled analysis of individual data from sub-Saharan Africa. , 2011, International journal of epidemiology.

[63]  H. Rammensee,et al.  CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. , 2010, Blood.

[64]  M. Altfeld,et al.  Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1 , 2009, Nature Medicine.

[65]  Judith N. Mandl,et al.  Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections , 2008, Nature Medicine.

[66]  Jakob Michaëlsson,et al.  Natural Killer Cells in Perinatally HIV-1-Infected Children Exhibit Less Degranulation Compared to HIV-1-Exposed Uninfected Children and Their Expression of KIR2DL3, NKG2C, and NKp46 Correlates with Disease Severity1 , 2007, The Journal of Immunology.

[67]  A. Zinn,et al.  Dynamic regulation of p53 subnuclear localization and senescence by MORC3. , 2007, Molecular biology of the cell.

[68]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[69]  L. Montaner,et al.  Dendritic and natural killer cell subsets associated with stable or declining CD4+ cell counts in treated HIV-1-infected children. , 2005, The Journal of infectious diseases.

[70]  Yibang Chen,et al.  Interaction of TRAF6 with MAST205 Regulates NF-κB Activation and MAST205 Stability* , 2004, Journal of Biological Chemistry.

[71]  Nigel Rollins,et al.  Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis , 2004, The Lancet.

[72]  R. Gelman,et al.  Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. , 2003, The Journal of allergy and clinical immunology.

[73]  Lieping Chen,et al.  Signaling Through NK Cell-Associated CD137 Promotes Both Helper Function for CD8+ Cytolytic T Cells and Responsiveness to IL-2 But Not Cytolytic Activity1 , 2002, The Journal of Immunology.

[74]  D. Ho,et al.  Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome , 1994, Journal of virology.

[75]  G. Ciliberto,et al.  Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli. , 1993, European journal of biochemistry.