Ropivacaine 1 mg  ·  ml−1 does not decrease the need for epidural fentanyl after hip replacement surgery

Background: Ropivacaine is a new long‐acting local anesthetic. Laboratory trials have demonstrated a synergistic analgesic effect between intrathecal opioids and local anesthetics. We tested the hypothesis that addition of ropivacaine 1 mg  ·  ml−1 to epidural fentanyl (10 μg  ·  ml−1) postoperatively decreases the need for fentanyl, improves the quality of analgesia and decreases the side‐effects of fentanyl.

[1]  M. Paech,et al.  A comparison of epidural ropivacaine infusion alone and in combination with 1, 2, and 4 microg/mL fentanyl for seventy-two hours of postoperative analgesia after major abdominal surgery. , 1999, Anesthesia and analgesia.

[2]  Spencer S. Liu,et al.  Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. , 1999, Anesthesiology.

[3]  E. McArthur,et al.  Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section. , 1999, British journal of anaesthesia.

[4]  A. Sandler,et al.  A review of the use of fentanyl analgesia in the management of acute pain in adults. , 1999, Anesthesiology.

[5]  K.,et al.  Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. , 1997, British journal of anaesthesia.

[6]  J. Laitinen,et al.  Intravenous ketoprofen for pain relief after total hip or knee replacement , 1996, Acta anaesthesiologica Scandinavica.

[7]  E. Crosby,et al.  Continuous epidural infusion of ropivacaine for the prevention of postoperative pain after major orthopaedic surgery: a dose-finding study , 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[8]  V. Vainionpää,et al.  0.1% Bupivacaine Does Not Reduce the Requirement for Epidural Fentanyl Infusion After Major Abdominal Surgery , 1994, Regional Anesthesia & Pain Medicine.

[9]  N. Badner,et al.  Bupivacaine 0.125% improves continuous postoperative epidural fentanyl analgesia after abdominal or thoracic surgery , 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[10]  M. Paech,et al.  Postoperative Epidural Fentanyl Infusion—is the Addition of 0.1% Bupivacaine of Benefit? , 1994, Anaesthesia and Intensive Care.

[11]  M. Kaneko,et al.  Synergistic Antinociceptive Interaction after Epidural Coadministration of Morphine and Lidocaine in Rats , 1994, Anesthesiology.

[12]  J. S. Goldberg,et al.  Use of patient-controlled analgesia to compare the efficacy of epidural to intravenous fentanyl administration. , 1992, Anesthesia and analgesia.

[13]  L. Nuutinen,et al.  Intravenous diclofenac coupled with PCA fentanyl for pain relief after total hip replacement. , 1992, Anesthesiology.

[14]  L. Nuutinen,et al.  A randomized double-blind comparison of epidural versus intravenous fentanyl infusion for analgesia after thoracotomy. , 1991, Anesthesiology.

[15]  T. Baker.  A HIGH DOSE REGIMEN OF TRIAMCINOLONE INDUCES RESISTANCE TO VECURONIUM NEUROMUSCULAR BLOCK IN CATS , 1991 .

[16]  D. Breen,et al.  Patient‐controlled on‐demand epidural fentanyl , 1991, Anaesthesia.

[17]  N. Badner,et al.  Low‐Dose Bupivacaine Does Not Improve Postoperative Epidural Fentanyl Analgesia in Orthopedic Patients , 1991, Anesthesia and analgesia.

[18]  S. Day,et al.  Sample size estimation for comparing two or more treatment groups in clinical trials. , 1991, Statistics in medicine.

[19]  B. Covino,et al.  Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. , 1990, Anesthesiology.

[20]  B. Covino,et al.  Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog , 1989, Anesthesia and analgesia.

[21]  M. Jensen,et al.  The Subjective Experience of Acute Pain An Assessment of the Utility of 10 Indices , 1989, The Clinical journal of pain.

[22]  B. Covino,et al.  Comparative Pharmacokinetics of Bupivacaine and Ropivacaine, a New Amide Local Anesthetic , 1988, Anesthesia and analgesia.

[23]  J. Kinney,et al.  SPLANCHNIC OXYGEN CONSUMPTION AND SUBSTRATE RALANCE FOLLOWING ACCIDENTAL INJURY , 1984 .

[24]  L. Mather,et al.  Intrathecal and epidural administration of opioids. , 1984, Anesthesiology.

[25]  E. Welchew.  The optimum concentration for epidural fentanyl. A randomised, double-blind comparison with and without 1:200 000 adrenaline. , 1984, Anaesthesia.

[26]  E. Welchew.  The optimum concentration for epidural fentanyl , 1983 .