Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK.

[1]  M. Askarian-Amiri,et al.  Signaling Pathways in Melanogenesis , 2016, International journal of molecular sciences.

[2]  Anuradha,et al.  FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes , 2016, Dermatologic therapy.

[3]  S. Chang,et al.  FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes , 2016, Pigment cell & melanoma research.

[4]  Eun-Young Kim,et al.  Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes , 2016, Scientific Reports.

[5]  M. Fukuda,et al.  RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes* , 2015, The Journal of Biological Chemistry.

[6]  M. Koketsu,et al.  Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF. , 2015, Journal of food science.

[7]  Jongsung Lee,et al.  Antibacterial Effects of Afzelin Isolated from Cornus macrophylla on Pseudomonas aeruginosa, A Leading Cause of Illness in Immunocompromised Individuals , 2014, Molecules.

[8]  R. Abdulah,et al.  Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. , 2012, Oncology letters.

[9]  Jongsung Lee,et al.  Mechanisms of melanogenesis inhibition by propafenone , 2010, Archives of Dermatological Research.

[10]  W. Flurkey,et al.  Variations in IC50 Values with Purity of Mushroom Tyrosinase , 2009, International journal of molecular sciences.

[11]  L. Steardo,et al.  Cannabidiol: A Promising Drug for Neurodegenerative Disorders? , 2009, CNS neuroscience & therapeutics.

[12]  Hyun Jung Kim,et al.  Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg , 2008, Archives of pharmacal research.

[13]  Jongsung Lee,et al.  Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling. , 2007, Life sciences.

[14]  S. Petrosino,et al.  Endocannabinoids and the regulation of their levels in health and disease , 2007, Current opinion in lipidology.

[15]  G. Scott,et al.  sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism. , 2006, The Journal of investigative dermatology.

[16]  N. Kogan.  Cannabinoids and cancer. , 2005, Mini reviews in medicinal chemistry.

[17]  T. Klein.  Cannabinoid-based drugs as anti-inflammatory therapeutics , 2005, Nature Reviews Immunology.

[18]  F. Bermúdez-Silva,et al.  The endocannabinoid system: physiology and pharmacology. , 2005, Alcohol and alcoholism.

[19]  Miyako Yoshida,et al.  Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. , 2005, Biological & pharmaceutical bulletin.

[20]  G. Wang,et al.  The effect of antisense tyrosinase‐related protein 1 on melanocytes and malignant melanoma cells , 2004, The British journal of dermatology.

[21]  Friedrich Beermann,et al.  Melanocytes and Pigmentation Are Affected in Dopachrome Tautomerase Knockout Mice , 2004, Molecular and Cellular Biology.

[22]  M. Khaled,et al.  Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway. , 2003, The Journal of investigative dermatology.

[23]  C. Newton,et al.  The cannabinoid system and immune modulation , 2003, Journal of leukocyte biology.

[24]  R. Mechoulam,et al.  Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. , 2002, Chemistry and physics of lipids.

[25]  M. Khaled,et al.  Glycogen Synthase Kinase 3β Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis* , 2002, The Journal of Biological Chemistry.

[26]  S. Sohn,et al.  Melasma: histopathological characteristics in 56 Korean patients , 2002, The British journal of dermatology.

[27]  R. Sturm.  Skin colour and skin cancer - MC1R, the genetic link. , 2002, Melanoma research.

[28]  R. Boissy,et al.  Tyrp1 and oculocutaneous albinism type 3. , 2001, Pigment cell research.

[29]  F. Solano,et al.  Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. , 2001, Journal of cell science.

[30]  K. Wakamatsu,et al.  Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. , 2001, Pigment cell research.

[31]  G. Barsh,et al.  Characterization of genes modulated during pheomelanogenesis using differential display. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[32]  K Takahashi,et al.  Functional Analysis of Microphthalmia-associated Transcription Factor in Pigment Cell-specific Transcription of the Human Tyrosinase Family Genes* , 1997, The Journal of Biological Chemistry.

[33]  A. Houghton,et al.  A melanosomal membrane protein is a cell surface target for melanoma therapy. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[34]  V. del Marmol,et al.  Tyrosinase and related proteins in mammalian pigmentation , 1996, FEBS letters.

[35]  G. Imokawa,et al.  Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis. , 1995, Journal of cell science.

[36]  G. Imokawa,et al.  Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. , 1994, The EMBO journal.

[37]  A. Ferré-D’Amaré,et al.  Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences , 1994, Nature Genetics.

[38]  K. Urabe,et al.  Functional analysis of the slaty gene product (TRP2) as dopachrome tautomerase and the effect of a point mutation on its catalytic function. , 1994, Biochemical and biophysical research communications.

[39]  J. Nordlund.  The pigmentary system and inflammation. , 1992, Pigment cell research.

[40]  T. Sarna,et al.  Properties and function of the ocular melanin--a photobiophysical view. , 1992, Journal of photochemistry and photobiology. B, Biology.

[41]  N. Copeland,et al.  A second tyrosinase‐related protein, TRP‐2, maps to and is mutated at the mouse slaty locus. , 1992, The EMBO journal.

[42]  A. Houghton,et al.  Biosynthesis and intracellular movement of the melanosomal membrane glycoprotein gp75, the human b (brown) locus product. , 1991, Experimental cell research.

[43]  H. Tagami,et al.  Possible Functional Impairment of Langerhans' Cells in Vitiliginous Skin: Reduced Ability to Elicit Dinitrochlorobenzene Contact Sensitivity Reaction and Decreased Stimulatory Effect in the Allogeneic Mixed Skin Cell Lymphocyte Culture Reaction , 1987 .

[44]  H. Tagami,et al.  Possible functional impairment of Langerhans' cells in vitiliginous skin. Reduced ability to elicit dinitrochlorobenzene contact sensitivity reaction and decreased stimulatory effect in the allogeneic mixed skin cell lymphocyte culture reaction. , 1987, Archives of dermatology.

[45]  M. Uehara,et al.  Diminished contact sensitivity response in vitiliginous skin. , 1984, Archives of dermatology.

[46]  B. Gilchrest,et al.  Effects of aging and chronic sun exposure on melanocytes in human skin. , 1979, The Journal of investigative dermatology.

[47]  R. Mechoulam,et al.  Hashish. I. The structure of cannabidiol. , 1963, Tetrahedron.

[48]  H. S. Mason,et al.  The free radical property of melanins. , 1960, Archives of biochemistry and biophysics.