HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia–telangiectasia cellular phenotype

[1]  X. Breakefield,et al.  Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep+ hybrid amplicon vector , 2003, Gene Therapy.

[2]  Bo Xu,et al.  Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. , 2002, Cancer research.

[3]  X. Breakefield,et al.  Herpes Simplex Virus Type 1/Adeno-Associated Virus rep+ Hybrid Amplicon Vector Improves the Stability of Transgene Expression in Human Cells by Site-Specific Integration , 2002, Journal of Virology.

[4]  C. Fraefel,et al.  Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrid Vectors Mediate Site-Specific Integration at the Adeno-Associated Virus Preintegration Site, AAVS1, on Human Chromosome 19 , 2002, Journal of Virology.

[5]  T. Mak,et al.  Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Bo Xu,et al.  Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways , 2002, Cell.

[7]  M. Kastan,et al.  Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. , 2002, Genes & development.

[8]  M. Kastan,et al.  Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation , 2002, Molecular and Cellular Biology.

[9]  E. Tyminski,et al.  An infectious transfer and expression system for genomic DNA loci in human and mouse cells , 2001, Nature Biotechnology.

[10]  H. Federoff,et al.  HSV vector-mediated gene delivery to the central nervous system. , 2001, Current opinion in molecular therapeutics.

[11]  Xiao-Fan Wang,et al.  ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses , 2001, Nature.

[12]  Bo Xu,et al.  Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation , 2001, Molecular and Cellular Biology.

[13]  X. Breakefield,et al.  Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  C. Miller,et al.  Development of a syngenic murine B16 cell line-derived melanoma susceptible to destruction by neuroattenuated HSV-1. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[15]  K. Khanna,et al.  ATM, a central controller of cellular responses to DNA damage , 2001, Cell Death and Differentiation.

[16]  M. Kastan,et al.  The many substrates and functions of ATM , 2000, Nature Reviews Molecular Cell Biology.

[17]  C. Fraefel,et al.  HSV-1 amplicon vectors--simplicity and versatility. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  Bo Xu,et al.  ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway , 2000, Nature.

[19]  H. Koyama,et al.  Site-specific integration of adeno-associated virus-based plasmid vectors in lipofected HeLa cells. , 2000, Virology.

[20]  Y. Shiloh,et al.  ATM: A mediator of multiple responses to genotoxic stress , 1999, Oncogene.

[21]  X. Breakefield,et al.  Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors. , 1999, Human gene therapy.

[22]  N. DeLuca,et al.  Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0 , 1999, Journal of Virology.

[23]  M. Meyn,et al.  Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation. , 1999, International journal of molecular medicine.

[24]  M. Meyn.  Ataxia‐telangiectasia, cancer and the pathobiology of the ATM gene , 1999, Clinical genetics.

[25]  Y Taya,et al.  Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. , 1998, Science.

[26]  John D Lambris,et al.  Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry , 1998, Journal of Virology.

[27]  Y. Shiloh,et al.  ATM: from gene to function. , 1998, Human molecular genetics.

[28]  M. Gatei,et al.  An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells , 1998, Oncogene.

[29]  Y Taya,et al.  DNA damage induces phosphorylation of the amino terminus of p53. , 1997, Genes & development.

[30]  M. Gatei,et al.  Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Yosef Shiloh,et al.  Recombinant ATM protein complements the cellular A-T phenotype , 1997, Oncogene.

[32]  M. Gatei,et al.  Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms , 1997, Oncogene.

[33]  F. Collins,et al.  The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Y. Shiloh,et al.  The genetic defect in ataxia-telangiectasia. , 1997, Annual review of immunology.

[35]  T. Stankovic,et al.  Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. , 1996, Oncogene.

[36]  Y. Shiloh,et al.  Ataxia-telangiectasia: founder effect among north African Jews. , 1996, Human molecular genetics.

[37]  P. Wild,et al.  Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells , 1996, Journal of virology.

[38]  M. Lavin,et al.  Defect in Multiple Cell Cycle Checkpoints in Ataxia-Telangiectasia Postirradiation* , 1996, The Journal of Biological Chemistry.

[39]  C. Caskey,et al.  A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[40]  F. Gage,et al.  In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector , 1996, Science.

[41]  T. Jorgensen,et al.  Radioresistant DNA synthesis in SV40-immortalized ataxia telangiectasia fibroblasts. , 1995, Radiation research.

[42]  M. Lovett,et al.  A single ataxia telangiectasia gene with a product similar to PI-3 kinase. , 1995, Science.

[43]  R. Linden,et al.  The cryptic life style of adenoassociated virus , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[44]  D. Easton.  Cancer risks in A-T heterozygotes. , 1994, International journal of radiation biology.

[45]  R. Mulligan,et al.  The basic science of gene therapy. , 1993, Science.

[46]  G. Nolan,et al.  Production of high-titer helper-free retroviruses by transient transfection. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. A. Hardwicke,et al.  Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression. , 1992, Virology.

[48]  X. Breakefield,et al.  A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons. , 1988, Science.

[49]  R. Spaete,et al.  The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector , 1982, Cell.

[50]  J. Darnell,et al.  Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes , 1981, Molecular and cellular biology.

[51]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.