Elastography for the pancreas: Current status and future perspective.

Elastography for the pancreas can be performed by either ultrasound or endoscopic ultrasound (EUS). There are two types of pancreatic elastographies based on different principles, which are strain elastography and shear wave elastography. The stiffness of tissue is estimated by measuring the grade of strain generated by external pressure in the former, whereas it is estimated by measuring propagation speed of shear wave, the transverse wave, generated by acoustic radiation impulse (ARFI) in the latter. Strain elastography is difficult to perform when the probe, the pancreas and the aorta are not located in line. Accordingly, a fine elastogram can be easily obtained in the pancreatic body but not in the pancreatic head and tail. In contrast, shear wave elastography can be easily performed in the entire pancreas because ARFI can be emitted to wherever desired. However, shear wave elastography cannot be performed by EUS to date. Recently, clinical guidelines for elastography specialized in the pancreas were published from Japanese Society of Medical Ultrasonics. The guidelines show us technical knacks of performing elastography for the pancreas.

[1]  S. Carrara,et al.  Pancreatic endoscopic ultrasound-guided fine needle aspiration: complication rate and clinical course in a single centre. , 2010, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[2]  F. Itokawa,et al.  EUS elastography combined with the strain ratio of tissue elasticity for diagnosis of solid pancreatic masses , 2011, Journal of Gastroenterology.

[3]  P1016 COMPARATIVE STUDY BETWEEN TWO POINT SHEAR WAVE ELASTOGRAPHIC TECHNIQUES: ACOUSTIC RADIATION FORCE IMPULSE (ARFI) ELASTOGRAPHY AND ElastPQ TECHNIQUE , 2014 .

[4]  Linda S. Lee,et al.  EUS-guided fine needle aspiration of pancreatic cysts: a retrospective analysis of complications and their predictors. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[5]  T. Matsumura,et al.  Breast disease: clinical application of US elastography for diagnosis. , 2006, Radiology.

[6]  N. Sasahira,et al.  Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis , 2012, Journal of Gastroenterology.

[7]  J. Iglesias-Garcia,et al.  EUS elastography for the characterization of solid pancreatic masses. , 2009, Gastrointestinal endoscopy.

[8]  M. Kudo,et al.  JSUM ultrasound elastography practice guidelines: liver , 2013, Journal of Medical Ultrasonics.

[9]  N. Kawada,et al.  Potential use of point shear wave elastography for the pancreas: a single center prospective study. , 2014, European journal of radiology.

[10]  J. Janssen,et al.  Effect of Aging and Diffuse Chronic Pancreatitis on Pancreas Elasticity Evaluated using Semiquantitative EUS Elastography , 2013, Ultraschall in der Medizin.

[11]  M. Golatta,et al.  Normal breast tissue stiffness measured by a new ultrasound technique: virtual touch tissue imaging quantification (VTIQ). , 2013, European journal of radiology.

[12]  K. Nam,et al.  Usefulness of acoustic radiation force impulse elastography in the differential diagnosis of benign and malignant solid pancreatic lesions , 2013, Ultrasonography.

[13]  G. Harris,et al.  Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses. , 2002, Ultrasound in medicine & biology.

[14]  N. Sata,et al.  Evidence-based clinical practice guidelines for chronic pancreatitis 2015 , 2016, Journal of Gastroenterology.

[15]  R. Pozzi Mucelli,et al.  Solid appearance of pancreatic serous cystadenoma diagnosed as cystic at ultrasound acoustic radiation force impulse imaging. , 2009, JOP : Journal of the pancreas.

[16]  H. Sugimoto,et al.  Quantitative analysis of diagnosing pancreatic fibrosis using EUS-elastography (comparison with surgical specimens) , 2014, Journal of Gastroenterology.

[17]  E. Carstensen,et al.  The influence of contrast agents on hemorrhage produced by lithotripter fields. , 1997, Ultrasound in medicine & biology.

[18]  F. Sanders,et al.  Severe acute pancreatitis after EUS-FNA of a pancreatic cyst: a rare, but serious complication , 2015, BMJ Case Reports.

[19]  M. Giovannini,et al.  Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study. , 2009, World journal of gastroenterology.

[20]  Utility of EUS: Elastography in the Diagnosis of Pancreatic Diseases , 2005 .

[21]  C. Göya,et al.  The utility of acoustic radiation force impulse imaging in diagnosing acute appendicitis and staging its severity. , 2014, Diagnostic and interventional radiology.

[22]  P. Vilmann,et al.  Differential diagnosis of focal pancreatic masses by semiquantitative EUS elastography: between strain ratios and strain histograms. , 2013, Gastrointestinal endoscopy.

[23]  H. Ohigashi,et al.  Periodic Ultrasonography Checkup for the Early Detection of Pancreatic Cancer: Preliminary Report , 2004, Pancreas.

[24]  Y. Takada,et al.  Quantification of pancreatic stiffness on intraoperative ultrasound elastography and evaluation of its relationship with postoperative pancreatic fistula. , 2015, International surgery.

[25]  E. Carstensen,et al.  Remnants of Albunex nucleate acoustic cavitation. , 1997, Ultrasound in medicine & biology.

[26]  X. Zou,et al.  Diagnostic value of EUS elastography in differentiation of benign and malignant solid pancreatic masses: a meta-analysis. , 2012, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[27]  Taiping Zhang,et al.  Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer: a meta-analysis. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[28]  Z. Ostojić,et al.  Endoscopic ultrasound elastography strain histograms in the evaluation of patients with pancreatic masses. , 2015, World journal of gastroenterology.

[29]  J. Leeds,et al.  Diagnostic accuracy of quantitative EUS elastography for discriminating malignant from benign solid pancreatic masses: a prospective, single-center study. , 2012, Gastrointestinal endoscopy.

[30]  M. Wallace,et al.  Risk of gastric or peritoneal recurrence, and long-term outcomes, following pancreatic cancer resection with preoperative endosonographically guided fine needle aspiration , 2013, Endoscopy.

[31]  P. Vilmann,et al.  Efficacy of an artificial neural network-based approach to endoscopic ultrasound elastography in diagnosis of focal pancreatic masses. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[32]  Alexandru Blidaru,et al.  Added value of Virtual Touch IQ shear wave elastography in the ultrasound assessment of breast lesions. , 2014, European journal of radiology.

[33]  Ioan Sporea,et al.  Acoustic Radiation Force Impulse elastography for fibrosis evaluation in patients with chronic hepatitis C: an international multicenter study. , 2012, European journal of radiology.

[34]  Tsuyoshi Shiina,et al.  WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 3: liver. , 2015, Ultrasound in medicine & biology.

[35]  M. Mcphail,et al.  EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis. , 2012, Gastrointestinal endoscopy.

[36]  O H Gilja,et al.  EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography.Part 2: Clinical Applications , 2013, Ultraschall in der Medizin.

[37]  A. Saftoiu,et al.  Can elastography replace fine needle aspiration? , 2014, Endoscopic ultrasound.

[38]  Yin Lu,et al.  Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesion: a systematic review , 2012, Journal of Cancer Research and Clinical Oncology.

[39]  Makoto Yamakawa,et al.  Recent progress of ultrasound elasticity imaging technology , 2004 .

[40]  M. Doyley,et al.  Strain imaging using combined RF and envelope autocorrelation processing , 1996, 1996 IEEE Ultrasonics Symposium. Proceedings.

[41]  J. E. Domínguez-Muñoz,et al.  Quantitative endoscopic ultrasound elastography: an accurate method for the differentiation of solid pancreatic masses. , 2010, Gastroenterology.

[42]  Y. Hirooka,et al.  Feasibility of Tissue Elastography Using Transcutaneous Ultrasonography for the Diagnosis of Pancreatic Diseases , 2009, Pancreas.

[43]  Ken Satoh,et al.  Diagnostic Accuracy of Real-Time Tissue Elastography for the Staging of Liver Fibrosis: A Meta-Analysis , 2014, European Radiology.

[44]  N. Sata,et al.  The revised Japanese clinical diagnostic criteria for chronic pancreatitis , 2010, Journal of Gastroenterology.

[45]  J. E. Domínguez-Muñoz,et al.  Quantitative elastography associated with endoscopic ultrasound for the diagnosis of chronic pancreatitis , 2013, Endoscopy.

[46]  J. Iglesias-Garcia,et al.  Endoscopic Ultrasonography of the Pancreas as an Indirect Method to Predict Pancreatic Exocrine Insufficiency in Patients With Chronic Pancreatitis , 2012, Pancreas.

[47]  T. Matsumura,et al.  Ex vivo and in vivo assessment of the non-linearity of elasticity properties of breast tissues for quantitative strain elastography. , 2014, Ultrasound in medicine & biology.

[48]  S. Bota,et al.  Comparative study between two point Shear Wave Elastographic techniques: Acoustic Radiation Force Impulse (ARFI) elastography and ElastPQ. , 2014, Medical ultrasonography.

[49]  Alteration of strain ratio evaluated by transabdominal ultrasound elastography may predict the efficacy of preoperative chemoradiation performed for pancreatic ductal carcinoma: preliminary results. , 2014, Hepato-gastroenterology.

[50]  C. Bassi,et al.  Virtual Analysis of Pancreatic Cystic Lesion Fluid Content by Ultrasound Acoustic Radiation Force Impulse Quantification , 2013, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[51]  Feasibility of second-generation transabdominal ultrasound-elastography to evaluate solid pancreatic tumors: preliminary report of 36 cases. , 2012, Pancreas.

[52]  M. Eloubeidi,et al.  How Good Is Endoscopic Ultrasound–Guided Fine-Needle Aspiration in Diagnosing the Correct Etiology for a Solid Pancreatic Mass?: A Meta-Analysis and Systematic Review , 2013, Pancreas.

[53]  T. Shiina,et al.  JSUM ultrasound elastography practice guidelines: pancreas , 2013, Journal of Medical Ultrasonics.

[54]  K. Omori,et al.  Stiffness of salivary gland and tumor measured by new ultrasonic techniques: Virtual touch quantification and IQ. , 2015, Auris, nasus, larynx.

[55]  J. Fleming,et al.  Role of EUS-FNA-Based Cytology in the Diagnosis of Mucinous Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis , 2010, Digestive Diseases and Sciences.

[56]  K. Shi,et al.  Clinical utility of acoustic radiation force impulse imaging for identification of malignant liver lesions: a meta-analysis , 2012, European Radiology.

[57]  Qiao Li,et al.  Performance of Real-Time Elastography for the Staging of Hepatic Fibrosis: A Meta-Analysis , 2014, PloS one.

[58]  P. Vilmann,et al.  Neural network analysis of dynamic sequences of EUS elastography used for the differential diagnosis of chronic pancreatitis and pancreatic cancer. , 2008, Gastrointestinal endoscopy.

[59]  M. Ziskin,et al.  Recommendations on the safe use of ultrasound contrast agents. , 2007, Ultrasound in medicine & biology.

[60]  Michael Golatta,et al.  Evaluation of Virtual Touch Tissue Imaging Quantification, a New Shear Wave Velocity Imaging Method, for Breast Lesion Assessment by Ultrasound , 2014, BioMed research international.

[61]  Myeong-Jin Kim,et al.  Prediction of Postoperative Pancreatic Fistulas After Pancreatectomy , 2014, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[62]  K. Togashi,et al.  Thyroid gland tumor diagnosis at US elastography. , 2005, Radiology.

[63]  M. Fukayama,et al.  Acoustic radiation force impulse imaging of the pancreas for estimation of pathologic fibrosis and risk of postoperative pancreatic fistula. , 2014, Journal of the American College of Surgeons.

[64]  W. Xu,et al.  Endoscopic ultrasound elastography for differentiating between pancreatic adenocarcinoma and inflammatory masses: a meta-analysis. , 2013, World journal of gastroenterology.

[65]  Dan Liu,et al.  EUS elastography for diagnosis of solid pancreatic masses: a meta-analysis. , 2013, Gastrointestinal endoscopy.

[66]  M. Friedrich-Rust,et al.  The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: a retrospective multicentre study. , 2013, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.