论文信息 - Comparison ofFluconazole andSDZ89-485 forTherapy of Experimental MurineCoccidioidomycosis

Comparison ofFluconazole andSDZ89-485 forTherapy of Experimental MurineCoccidioidomycosis

predict in vivoactivity. Others have shownthat ketoconazole hasbetterinvitro antifungal activity than fluconazole, but the reverse istruein vivo(7, 8). Fluconazoleappearstohavelittle activityin vitro againstC. immitis, yetthis studyandpreviousworkby Graybill et al. show it to be active in vivo (9). Sincefluconazole is not metabolically altered in vivo, it mustbeconcludedthat in vitro methodsfortesting fluconazole (andotherazoles)arenotyetreliable. Untilareliable methodforin

T. Kirkland

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