Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation.

[1]  Jeffrey A. Diamond,et al.  STAT5 is a potent negative regulator of TFH cell differentiation , 2012, The Journal of experimental medicine.

[2]  Laurence A. Turka,et al.  Faculty Opinions recommendation of Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. , 2011 .

[3]  K. Legge,et al.  T regulatory cells participate in the control of germinal centre reactions , 2011, Immunology.

[4]  Tim F. Rayner,et al.  Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response , 2011, Nature Medicine.

[5]  S. Crotty,et al.  ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. , 2011, Immunity.

[6]  C. King A fine romance: T follicular helper cells and B cells. , 2011, Immunity.

[7]  J. Kolls,et al.  The development of inducible Bronchus Associated Lymphoid Tissue (iBALT) is dependent on IL-17 , 2011, Nature Immunology.

[8]  M. Lenardo,et al.  CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. , 2011, Immunity.

[9]  T. Mcclanahan,et al.  Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. , 2011, Immunity.

[10]  S. Crotty,et al.  Follicular helper CD4 T cells (TFH). , 2011, Annual review of immunology.

[11]  D. Campbell,et al.  Phenotypical and functional specialization of FOXP3+ regulatory T cells , 2011, Nature Reviews Immunology.

[12]  S. Tangye,et al.  Regulation of T follicular helper cell formation and function by antigen presenting cells. , 2011, Current opinion in immunology.

[13]  J. Cyster B cell follicles and antigen encounters of the third kind , 2010, Nature Immunology.

[14]  C. Vinuesa,et al.  The elusive identity of T follicular helper cells. , 2010, Trends in immunology.

[15]  J. Bluestone,et al.  IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells , 2010, The Journal of experimental medicine.

[16]  T. Malek,et al.  Interleukin-2 receptor signaling: at the interface between tolerance and immunity. , 2010, Immunity.

[17]  C. Goodnow,et al.  T cells and follicular dendritic cells in germinal center B‐cell formation and selection , 2010, Immunological reviews.

[18]  C. Goodnow,et al.  Control systems and decision making for antibody production , 2010, Nature Immunology.

[19]  S. Kaech,et al.  In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development , 2010, The Journal of Immunology.

[20]  Lieping Chen,et al.  PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells , 2010, Nature Immunology.

[21]  M. Linterman,et al.  IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses , 2010, The Journal of experimental medicine.

[22]  W. Haining,et al.  Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. , 2010, Immunity.

[23]  M. Bevan,et al.  Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. , 2010, Immunity.

[24]  A. Scheffold,et al.  Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus , 2009, Proceedings of the National Academy of Sciences.

[25]  C. Mackay,et al.  The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. , 2009, Immunity.

[26]  Burton E. Barnett,et al.  Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation , 2009, Science.

[27]  R. Nurieva,et al.  Bcl6 Mediates the Development of T Follicular Helper Cells , 2009, Science.

[28]  T. Okazaki,et al.  PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo1 , 2009, The Journal of Immunology.

[29]  Kim L Kusser,et al.  Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. , 2009, Immunity.

[30]  N. Fazilleau,et al.  The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding , 2009, Nature Immunology.

[31]  D. Beckett,et al.  A minimal peptide substrate in biotin holoenzyme synthetase‐catalyzed biotinylation , 2008, Protein science : a publication of the Protein Society.

[32]  C. Mackay,et al.  A fundamental role for interleukin-21 in the generation of T follicular helper cells. , 2008, Immunity.

[33]  T. Malek,et al.  The biology of interleukin-2. , 2008, Annual review of immunology.

[34]  Y. Li,et al.  Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells1 , 2007, The Journal of Immunology.

[35]  J. Cyster,et al.  Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 , 2007, The Journal of Immunology.

[36]  J. Cyster,et al.  Germinal-center organization and cellular dynamics. , 2007, Immunity.

[37]  L. Hennighausen,et al.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.

[38]  G. Freeman,et al.  The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection , 2007, Nature Immunology.

[39]  A. Rudensky,et al.  Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice , 2007, Nature Immunology.

[40]  T. Malek,et al.  Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production1 , 2007, The Journal of Immunology.

[41]  Yan Tang,et al.  Recombinant Interleukin-2 Significantly Augments Activity of Rituximab in Human Tumor Xenograft Models of B-cell Non-Hodgkin Lymphoma , 2007, Journal of immunotherapy.

[42]  A. Tyznik,et al.  Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells , 2006, Nature.

[43]  T. Randall,et al.  CD4 T Cell-Independent Antibody Response Promotes Resolution of Primary Influenza Infection and Helps to Prevent Reinfection1 , 2005, The Journal of Immunology.

[44]  A. Banham,et al.  Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells1 , 2005, The Journal of Immunology.

[45]  R. Förster,et al.  Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. , 2005, Blood.

[46]  S. Gillies,et al.  An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma. , 2005, Blood.

[47]  P. Hillsamer,et al.  Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. , 2004, The Journal of clinical investigation.

[48]  T. Malek,et al.  Tolerance, not immunity, crucially depends on IL-2 , 2004, Nature Reviews Immunology.

[49]  S. Rutz,et al.  Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function , 2004, European journal of immunology.

[50]  A. Difrancesco,et al.  Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin’s Lymphoma , 2004, Clinical Cancer Research.

[51]  R. Cox,et al.  Influenza Virus: Immunity and Vaccination Strategies. Comparison of the Immune Response to Inactivated and Live, Attenuated Influenza Vaccines , 2004, Scandinavian journal of immunology.

[52]  E. Wherry,et al.  Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo , 2003, Nature Medicine.

[53]  A. Freitas,et al.  Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.

[54]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[55]  J. Gribben,et al.  Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non‐Hodgkin's lymphoma , 2002, British journal of haematology.

[56]  R. Lempicki,et al.  Interleukin‐2 induced immune effects in human immunodeficiency virus‐infected patients receiving intermittent interleukin‐2 immunotherapy , 2001, European journal of immunology.

[57]  G. Kelsoe,et al.  The germinal center: a crucible for lymphocyte selection. , 1996, Seminars in immunology.

[58]  R. Noelle,et al.  Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells , 1995, European journal of immunology.

[59]  R. Zinkernagel,et al.  Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4 , 1995, Journal of virology.

[60]  B Zheng,et al.  Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. , 1995, Journal of immunology.

[61]  H. Griesser,et al.  Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. , 1995, Science.

[62]  A. Feller,et al.  Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene , 1993, Cell.

[63]  M. Lenardo lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis , 1991, Nature.

[64]  A. Chang,et al.  Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. , 1985, The New England journal of medicine.

[65]  S. Rosenberg,et al.  Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2 , 1985, The Journal of experimental medicine.