Treatment with resveratrol attenuates sublesional bone loss in spinal cord‐injured rats

Sublesional osteoporosis predisposes individuals with spinal cord injury (SCI) to an increased risk of low‐trauma fracture. The aim of the present work was to investigate the effect of treatment with resveratrol (RES) on sublesional bone loss in spinal cord‐injured rats.

[1]  Timothy M. Errington,et al.  Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota , 2018, eLife.

[2]  Fanxin Long,et al.  β‐catenin promotes bone formation and suppresses bone resorption in postnatal growing mice , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  F. Shuang,et al.  Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats , 2013, Osteoporosis International.

[4]  Lei-Sheng Jiang,et al.  Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling , 2012, Journal of cellular and molecular medicine.

[5]  L. Giangregorio,et al.  Serum 25(OH)D, PTH and Correlates of Suboptimal 25(OH)D Levels in Persons with Chronic Spinal Cord Injury , 2012, Spinal Cord.

[6]  A. Mobasheri,et al.  Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation , 2012, PloS one.

[7]  L. Morse,et al.  Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction , 2011, Translational Stroke Research.

[8]  Stephen P. H. Alexander,et al.  Guide to Receptors and Channels (GRAC), 5th edition , 2011, British journal of pharmacology.

[9]  H. Zhu,et al.  Oxidative stress in spinal cord injury and antioxidant-based intervention , 2011, Spinal Cord.

[10]  L. Dai,et al.  Down-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in osteoblasts from rats with chronic spinal cord injury. , 2011, Joint, bone, spine : revue du rhumatisme.

[11]  D. Desplanches,et al.  Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  Kunzheng Wang,et al.  Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury , 2011, Brain Research.

[13]  David Brasse,et al.  Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension , 2011, Journal of Bone and Mineral Metabolism.

[14]  A. Mobasheri,et al.  Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells , 2011, The Journal of Biological Chemistry.

[15]  G. Andersson,et al.  Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. , 2010, Biochemical and biophysical research communications.

[16]  C. Kilkenny,et al.  Guidelines for reporting experiments involving animals: the ARRIVE guidelines , 2010, British journal of pharmacology.

[17]  T. Szkudelski,et al.  Resveratrol, obesity and diabetes. , 2010, European journal of pharmacology.

[18]  Xiyu Zhang,et al.  Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. , 2009, Experimental cell research.

[19]  G. Burdock,et al.  Safety studies conducted on high-purity trans-resveratrol in experimental animals. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[20]  M. Almeida,et al.  Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton* , 2009, The Journal of Biological Chemistry.

[21]  L. Dai,et al.  Effects of spinal cord injury and hindlimb immobilization on sublesional and supralesional bones in young growing rats. , 2008, Bone.

[22]  R. Müller,et al.  Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats) , 2008, Osteoporosis International.

[23]  J A Peters,et al.  Guide to Receptors and Channels (GRAC), 3rd edition , 2008, British journal of pharmacology.

[24]  Matthew R Allen,et al.  Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin* , 2008, Journal of Biological Chemistry.

[25]  Y. Wan,et al.  PPAR-γ regulates osteoclastogenesis in mice , 2007, Nature Medicine.

[26]  L. Dai,et al.  Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats , 2007, Osteoporosis International.

[27]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[28]  L. Dai,et al.  Mechanisms of osteoporosis in spinal cord injury , 2006, Clinical endocrinology.

[29]  N. Ishimaru,et al.  Ubiquitin Ligase Cbl‐b Downregulates Bone Formation Through Suppression of IGF‐I Signaling in Osteoblasts During Denervation , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  C E Webber,et al.  Body weight supported treadmill training in acute spinal cord injury: impact on muscle and bone , 2005, Spinal Cord.

[31]  W. Li,et al.  Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. , 2005, Journal of medicinal food.

[32]  Ying-bao Yang,et al.  Effects of resveratrol on secondary damages after acute spinal cord injury in rats. , 2003, Acta pharmacologica Sinica.

[33]  Y. Maugars,et al.  Supralesional and sublesional bone mineral density in spinal cord-injured patients. , 2000, Bone.

[34]  R. Jilka,et al.  Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2 , 1999, Journal of cellular biochemistry.

[35]  N. Paker,et al.  Osteoporosis after spinal cord injury , 1998, Spinal Cord.

[36]  P. Fondu,et al.  Increased Osteoclast-Like Cells Formation in Long-Term Bone Marrow Cultures from Patients with a Spinal Cord Injury , 1998, Calcified Tissue International.

[37]  K. Klose,et al.  Evaluation of a training program for persons with SCI paraplegia using the Parastep 1 ambulation system: part 3. Lack of effect on bone mineral density. , 1997, Archives of physical medicine and rehabilitation.

[38]  A. Parfitt,et al.  Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. , 1996, The Journal of clinical investigation.

[39]  P. Bergmann,et al.  Longitudinal study of the bone mineral content and of soft tissue composition after spinal cord section , 1995, Paraplegia.

[40]  S. Mohan,et al.  The insulin-like growth factor system and the coupling of formation to resorption. , 1995, Bone.

[41]  Toshitaka Nakamura,et al.  Intermittent cyclical etidronate treatment maintains the mass, structure and the mechanical property of bone in ovariectomized rats , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  A. Spungen,et al.  Blunted Growth Hormone Response to Intravenous Arginine in Subjects with a Spinal Cord Injury , 1994, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[43]  C. Sutton,et al.  Hyposomatomedinemia in quadriplegic men. , 1993, The American journal of the medical sciences.

[44]  R. Adkins,et al.  Osteoporosis after spinal cord injury , 1992, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[45]  P. Pietschmann,et al.  Increased serum osteocalcin levels in patients with paraplegia , 1992, Paraplegia.

[46]  A. Parfitt Bone histomorphometry: standardization of nomenclature, symbols and units. Summary of proposed system. , 1988, Bone and mineral.

[47]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987 .

[48]  A. Robling,et al.  Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. , 2012, Bone.

[49]  L. Peshkin,et al.  Supplemental Data Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span , 2008 .

[50]  W. Chiu,et al.  Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats. , 2007, Journal of neurosurgery. Spine.

[51]  Y. Wan,et al.  PPAR-gamma regulates osteoclastogenesis in mice. , 2007, Nature medicine.

[52]  L. Harvey,et al.  Does 12 weeks of regular standing prevent loss of ankle mobility and bone mineral density in people with recent spinal cord injuries? , 2005, The Australian journal of physiotherapy.

[53]  Paula Kocina Body Composition of Spinal Cord Injured Adults , 1997, Sports medicine.

[54]  L. Mosekilde,et al.  The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. , 1993, Bone.

[55]  R. Weinstein The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage* , 2022 .