Comparative evaluation of the developed targeted RNA sequencing system and a commercialized test panel

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. Frequency of gene fusions detected in various types of leukemia using our targeted RNA-seq system. (A) Black bars indicate the frequency of gene fusions detected in patients with each leukemia type. Gene fusion was detected in 77% (72 patients) of all the 93 leukemia patients. Genetic fusion mutations were observed in 94% (33/35) of adult B-ALL patients and 83% (25/30) of pediatric B-ALL patients. (B) Gene fusion pattern and frequency for each type of leukemia. Among the gene fusions found in adult B-ALL (N=35), the most common fusion gene was BCR-ABL1 (24/33, 73%), and the most common fusion gene mutation in childhood B-ALL was ETV6-RUNX1 (4/26, 15%). Abbreviation: RNA-seq, RNA sequencing. BLOOD RESEARCH Volume 57ᆞNumber 3ᆞSeptember 2022