Chemosensory event-related brain potentials (CSERP) after strictly monorhinal stimulation.

Using flow-olfactometer for chemosensory event related brain potentials (CSERP) the air escapes the contralateral nostril from the stimulated nostril via the nasopharynx. Theoretically, the escaping odorous airflow is able to stimulate the contralateral chemosensory receptors and might activate the olfactory or the trigeminal brain processes. Testing 18 healthy subjects, we were able to show that it was possible to generate CSERP by strictly monorhinal stimulation with closed contralateral nostril. That means that the rectangular shapes of the brief chemosensory stimuli were not disturbed. The latencies of N1 and P2 and the amplitudes (N1P2) of CSERP (stimulants: H2S and CO2) were not different with either open or closed contralateral nostril. The induced CSERP were independent of stimulated nostril side. Additionally we found that with closed contralateral nostril more than 90% of passive monorhinal chemosensory stimuli were perceived. In further imaging studies the presented paradigm should be applied with strictly monorhinal stimulation to investigate the chemosensory processing pathways with high time resolution (EEG/MEG).

[1]  G Kobal,et al.  "Sniffin' sticks": screening of olfactory performance. , 1996, Rhinology.

[2]  G Kobal,et al.  Differences in human evoked potentials related to olfactory or trigeminal chemosensory activation. , 1992, Electroencephalography and clinical neurophysiology.

[3]  G Kobal,et al.  Chemosensory event-related potentials change with age. , 1998, Electroencephalography and clinical neurophysiology.

[4]  K. Hörmann,et al.  Chemosensory event-related potentials in relation to side of stimulation, age, sex, and stimulus concentration , 2006, Clinical Neurophysiology.

[5]  T. Hummel,et al.  Intranasal concentrations of orally administered flavors. , 2005, Chemical senses.

[6]  G Kobal,et al.  [Objective olfactometry: methodological annotations for recording olfactory EEG-responses from the awake human]. , 1978, EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete.

[7]  Jonas K. Olofsson,et al.  Gender differences in chemosensory perception and event-related potentials. , 2004, Chemical senses.

[8]  A. Mouraux,et al.  Lateralisation of intranasal trigeminal chemosensory event-related potentials , 2008, Neurophysiologie Clinique/Clinical Neurophysiology.

[9]  H. Stefan,et al.  Multiple olfactory activity in the human neocortex identified by magnetic source imaging. , 1997, Chemical senses.

[10]  I. Homma,et al.  Inspiratory phase‐locked alpha oscillation in human olfaction: source generators estimated by a dipole tracing method , 2005, The Journal of physiology.

[11]  Gerd Kobal,et al.  Differences in human chemosensory evoked potentials to olfactory and somatosensory chemical stimuli presented to left and right nostrils , 1992 .

[12]  A. Mackay-Sim,et al.  Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects , 2007, European Archives of Oto-Rhino-Laryngology.

[13]  G Kobal,et al.  Olfactory functional imaging and physiology. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[14]  Y. Okada,et al.  Modeling and Detecting Deep Brain Activity with MEG & EEG , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[15]  C. M. Michel,et al.  Spatio–temporal dynamics of olfactory processing in the human brain: an event-related source imaging study , 2010, Neuroscience.

[16]  M. Walther,et al.  Comparison of the orthonasal and retronasal detection thresholds for carbon dioxide in humans. , 2011, Chemical senses.

[17]  T. Hummel,et al.  Topographical differences in the trigeminal sensitivity of the human nasal mucosa , 2006, Neuroreport.

[18]  Steven Nordin,et al.  Laterality of the olfactory event-related potential response. , 2006, Chemical senses.

[19]  A. Mouraux,et al.  Assessment of olfactory and trigeminal function using chemosensory event-related potentials , 2006, Neurophysiologie Clinique/Clinical Neurophysiology.