Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling

[1]  Cody C. Gifford,et al.  Emerging role of tumor suppressor p53 in acute and chronic kidney diseases , 2022, Cellular and Molecular Life Sciences.

[2]  Youhua Liu,et al.  Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling. , 2022, Kidney international.

[3]  M. Ebert,et al.  Cross-Talk between p53 and Wnt Signaling in Cancer , 2022, Biomolecules.

[4]  Zhi-Lin Luan,et al.  Nuclear receptors in renal health and disease , 2022, EBioMedicine.

[5]  Y. Guan,et al.  A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury. , 2021, American journal of physiology. Renal physiology.

[6]  A. Levin,et al.  Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2 , 2021, Kidney international reports.

[7]  D. Serra,et al.  Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. , 2021, The Journal of clinical investigation.

[8]  Xianmei Zhou,et al.  Citrus Alkaline Extracts Inhibit Senescence of A549 Cells to Alleviate Pulmonary Fibrosis via the β-Catenin/P53 Pathway , 2021, Medical science monitor : international medical journal of experimental and clinical research.

[9]  Yuan-yi Wei,et al.  Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. , 2020, Biochimica et biophysica acta. Molecular basis of disease.

[10]  Lu Tie,et al.  A brief guide to good practices in pharmacological experiments: Western blotting , 2020, Acta Pharmacologica Sinica.

[11]  H. Ding,et al.  p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease. , 2020, The Journal of clinical investigation.

[12]  Zhanjun Jia,et al.  Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI , 2020, Science Translational Medicine.

[13]  M. Thorsteinsdóttir,et al.  Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. , 2019, Kidney international.

[14]  Youhua Liu,et al.  Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction , 2019, Aging cell.

[15]  J. Pedraza-Chaverri,et al.  Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments , 2019, Biomolecules.

[16]  F. Hou,et al.  N‐acetylcysteine ameliorates cisplatin‐induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation , 2019, Free radical biology & medicine.

[17]  N. Tang,et al.  Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. , 2018, Toxicology letters.

[18]  Youhua Liu,et al.  New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis , 2018, Nephrology.

[19]  G. Anton,et al.  Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome , 2018, Journal of immunology research.

[20]  Li Yang,et al.  Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells. , 2018, Journal of the American Society of Nephrology : JASN.

[21]  H. Aburatani,et al.  Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney. , 2018, American journal of physiology. Renal physiology.

[22]  Yi Tang,et al.  TGF-β1/p53 signaling in renal fibrogenesis. , 2018, Cellular signalling.

[23]  J. Rysä,et al.  Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver , 2018, Biochemical pharmacology.

[24]  Junwei Yang,et al.  Wnt/β-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis. , 2017, Journal of the American Society of Nephrology : JASN.

[25]  J. Massagué,et al.  The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. , 2017, Cell stem cell.

[26]  H. Pavenstädt,et al.  Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog , 2016, Nature Reviews Nephrology.

[27]  Youhua Liu,et al.  Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression. , 2016, Journal of the American Society of Nephrology : JASN.

[28]  M. Breyer,et al.  The next generation of therapeutics for chronic kidney disease , 2016, Nature Reviews Drug Discovery.

[29]  R. Bank,et al.  Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge , 2015, Front. Med..

[30]  S. Kliewer Nuclear receptor PXR: discovery of a pharmaceutical anti-target. , 2015, The Journal of clinical investigation.

[31]  F. Kaskel,et al.  Update on Inflammation in Chronic Kidney Disease , 2015, Blood Purification.

[32]  Jinu Kim,et al.  Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. , 2014, Journal of the American Society of Nephrology : JASN.

[33]  R. Samarakoon,et al.  Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity. , 2014, Cellular signalling.

[34]  Katalin Susztak,et al.  Molecular mechanisms of diabetic kidney disease. , 2014, The Journal of clinical investigation.

[35]  M. Neovius,et al.  Mortality in chronic kidney disease and renal replacement therapy: a population-based cohort study , 2014, BMJ Open.

[36]  Chun Cheng,et al.  Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway , 2013, Molecular and Cellular Biochemistry.

[37]  S. Al-Salam,et al.  New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: comparison with rats. , 2013, Journal of pharmacological and toxicological methods.

[38]  V. Jha,et al.  Chronic kidney disease: global dimension and perspectives , 2013, The Lancet.

[39]  Youhua Liu,et al.  Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling. , 2013, Journal of the American Society of Nephrology : JASN.

[40]  R. Moon,et al.  LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1 , 2013, Proceedings of the National Academy of Sciences.

[41]  Yongjie Ma,et al.  Activation of Pregnane X Receptor by Pregnenolone 16 α-carbonitrile Prevents High-Fat Diet-Induced Obesity in AKR/J Mice , 2012, PloS one.

[42]  Youhua Liu Cellular and molecular mechanisms of renal fibrosis , 2011, Nature Reviews Nephrology.

[43]  D. Brazil,et al.  CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy , 2011, FEBS letters.

[44]  W. Hennink,et al.  Drug targeting to the kidney: Advances in the active targeting of therapeutics to proximal tubular cells. , 2010, Advanced drug delivery reviews.

[45]  S. Hill,et al.  Journal of Steroid Biochemistry and Molecular Biology the Pxr Is a Drug Target for Chronic Inflammatory Liver Disease , 2022 .

[46]  Lingyi Chen,et al.  A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells , 2009, Proceedings of the National Academy of Sciences.

[47]  P. Desmond,et al.  Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease , 2009, Journal of gastroenterology and hepatology.

[48]  Youhua Liu,et al.  Wnt/beta-catenin signaling promotes renal interstitial fibrosis. , 2009, Journal of the American Society of Nephrology : JASN.

[49]  M. Wright The impact of pregnane X receptor activation on liver fibrosis. , 2006, Biochemical Society transactions.

[50]  C. J. Marek,et al.  Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro. , 2006, Gastroenterology.

[51]  A. Garg,et al.  Chronic kidney disease and mortality risk: a systematic review. , 2006, Journal of the American Society of Nephrology : JASN.

[52]  K. Hruska,et al.  Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. , 2005, Journal of the American Society of Nephrology : JASN.

[53]  C. J. Marek,et al.  Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. , 2005, The Biochemical journal.

[54]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[55]  Mario Huerta,et al.  Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN , 2003, Nucleic Acids Res..

[56]  Xavier Messeguer,et al.  PROMO: detection of known transcription regulatory elements using species-tailored searches , 2002, Bioinform..

[57]  J. Lehmann,et al.  An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.

[58]  A. Nemmar,et al.  Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats. , 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

[59]  Zhihong Liu,et al.  Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease. , 2017, Kidney international.

[60]  S. Ozawa,et al.  Effect of nuclear receptor downregulation on hepatic expression of cytochrome P450 and transporters in chronic hepatitis C in association with fibrosis development. , 2012, Drug metabolism and pharmacokinetics.