Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

[1]  F. Gonzalez,et al.  A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. , 1991, Chemical research in toxicology.

[2]  A. Natarajan,et al.  Use of human hepatoma cells for in vitro metabolic activation of chemical mutagens/carcinogens. , 1991, Mutagenesis.

[3]  F. Gonzalez,et al.  A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. , 1991, Carcinogenesis.

[4]  H. Ramsdell,et al.  Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes. , 1991, Toxicology and applied pharmacology.

[5]  J. A. Bond,et al.  Particle-associated polycyclic aromatic hydrocarbons--a reappraisal of their possible role in pulmonary carcinogenesis. , 1991, Toxicology and applied pharmacology.

[6]  F. Guengerich,et al.  Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. , 1991, Chemical research in toxicology.

[7]  F. Gonzalez,et al.  The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. , 1991, Carcinogenesis.

[8]  M. P. Arlotto,et al.  Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1 , 1990 .

[9]  F. Gonzalez,et al.  The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. , 1990, Biochemistry.

[10]  H. Ramsdell,et al.  Comparative Kinetics of Microsomal Biotransformation Species Susceptibility to Aflatoxin B1 Carcinogenesis , 1990 .

[11]  L. Marnett,et al.  Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. , 1989, Cancer research.

[12]  T. Aoyama,et al.  Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. , 1989, The Journal of biological chemistry.

[13]  T. Shimada,et al.  Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. , 1989, Cancer research.

[14]  R. Langenbach,et al.  Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens. , 1989, Carcinogenesis.

[15]  Yao-Tseng Chen,et al.  Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. , 1989, Carcinogenesis.

[16]  F. Gonzalez,et al.  The molecular biology of cytochrome P450s. , 1988, Pharmacological reviews.

[17]  T. Kronbach,et al.  High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. , 1987, Analytical biochemistry.

[18]  B. W. Penman,et al.  Mutagenicity of 1,2-dichloroethane and 1,2-dibromoethane in two human lymphoblastoid cell lines. , 1985, Mutation research.

[19]  J. Yates,et al.  A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus , 1985, Molecular and cellular biology.

[20]  W. Thilly,et al.  Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism. , 1984, Mutation research.

[21]  O. Hankinson,et al.  Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase. , 1983, Cancer research.

[22]  J. Minowada,et al.  Induction, inhibition, and biological properties of aryl hydrocarbon hydroxylase in a stable human B-lymphocyte cell line, RPMI-1788. , 1979, Cancer research.

[23]  B. Paigen,et al.  Aryl hydrocarbon hydroxylase in a stable human B-lymphocyte cell line, RPMI-1788, cultured in the absence of mitogen. , 1979, Cancer research.

[24]  J. Smyth,et al.  Progress in Clinical and Biological Research , 1979 .

[25]  B. Ames,et al.  Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Malling.  Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes. , 1971, Mutation research.

[27]  C. Crespi.  Expression of cytochrome P450 cDNAs in human B lymphoblastoid cells: applications to toxicology and metabolite analysis. , 1991, Methods in enzymology.

[28]  F. Gonzalez,et al.  Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: Role of the enzyme in the metabolic activation of aflatoxin B1 , 1990, Molecular carcinogenesis.

[29]  R. Langenbach,et al.  The development of a panel of human cell lines expressing specific human cytochrome P450 cDNAs. , 1990, Progress in clinical and biological research.

[30]  B. W. Penman,et al.  Sodium fluoride is a less efficient human cell mutagen at low concentrations , 1990, Environmental and molecular mutagenesis.

[31]  B. W. Penman,et al.  The induction of aneuploidy by nitrogen mustard in a human lymphoblastoid cell line. , 1987, Mutation research.

[32]  M. Marletta,et al.  Xenobiotic metabolism and mutation in a human lymphoblastoid cell line. , 1985, Chemico-biological interactions.

[33]  E. Furth,et al.  Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. , 1981, Analytical biochemistry.

[34]  S. Colowick,et al.  Methods in Enzymology , Vol , 1966 .