Transcranial direct current stimulation promotes the mobility of engrafted NSCs in the rat brain

Transcranial direct current stimulation (tDCS) is used in numerous clinical studies and considered an effective and versatile add‐on therapy in neurorehabilitation. To date, however, the underlying neurobiological mechanisms remain elusive. In a rat model of tDCS, we recently observed a polarity‐dependent accumulation of endogenous neural stem cells (NSCs) in the stimulated cortex. Based upon these findings, we hypothesized that tDCS may exert a direct migratory effect on endogenous NSCs towards the stimulated cortex. Using noninvasive imaging, we here investigated whether tDCS may also cause a directed migration of engrafted NSCs.

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