The origin of pattern and polarity in the Drosophila embryo

[1]  E. Wilson,et al.  The Cell In Development And Heredity , 1925 .

[2]  R. Ruggles-Gates,et al.  The cell in development and heredity , 1927 .

[3]  A. Mahowald.  Polar granules of Drosophila. II. Ultrastructural changes during early embryogenesis. , 1968, The Journal of experimental zoology.

[4]  A. Mahowald,et al.  Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the egg. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[5]  C. Audit,et al.  Isolation and characterization of sex-linked female-sterile mutants in Drosophila melanogaster. , 1975, Genetics.

[6]  M. Loomis,et al.  The ontogeny of germ plasm during oogenesis in Drosophila. , 1976, Developmental biology.

[7]  C. Nüsslein-Volhard,et al.  A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila , 1980, Nature.

[8]  N. Perrimon,et al.  Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. , 1983, Developmental biology.

[9]  J. Slack.  From Egg to Embryo , 1983 .

[10]  C. Nüsslein-Volhard,et al.  Partial rescue of dorsal, a maternal effect mutation affecting the dorso‐ventral pattern of the Drosophila embryo, by the injection of wild‐type cytoplasm , 1983, The EMBO journal.

[11]  K. Anderson,et al.  Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA , 1984, Nature.

[12]  A. Mahowald,et al.  tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster , 1985, Cell.

[13]  H. Jäckle,et al.  An early role of maternal mRNA in establishing the dorsoventral pattern in pelle mutant Drosophila embryos. , 1985, Developmental biology.

[14]  K. Anderson,et al.  Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene product , 1985, Cell.

[15]  N. Perrimon,et al.  A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster. , 1985, Developmental biology.

[16]  K. Anderson,et al.  Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product , 1985, Cell.

[17]  H. Jäckle,et al.  Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos , 1985, Nature.

[18]  E. Wieschaus,et al.  Germline autonomy of maternal-effect mutations altering the embryonic body pattern of Drosophila. , 1986, Developmental biology.

[19]  R. Delotto,et al.  A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease , 1986, Nature.

[20]  R. Lehmann,et al.  Manipulating the anteroposterior pattern of the Drosophila embryo. , 1986, Journal of embryology and experimental morphology.

[21]  J. Goebels,et al.  Histochemical and autoradiographic study of the cultured rat visceral yolk sac. , 1986, Journal of embryology and experimental morphology.

[22]  C. Nüsslein-Volhard,et al.  Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid , 1986, Nature.

[23]  Ruth Lehmann,et al.  Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in drosophila , 1986, Cell.

[24]  M. Noll,et al.  Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network , 1986, Cell.

[25]  H. Jäckle,et al.  Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA , 1986, Nature.

[26]  R. Lehmann,et al.  hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo. , 1987, Developmental biology.

[27]  W. Gelbart,et al.  A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family , 1987, Nature.

[28]  R. Lehmann,et al.  Involvement of the pumilio gene in the transport of an abdominal signal in the Drosophila embryo , 1987, Nature.

[29]  Diethard Tautz,et al.  Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes , 1987, Nature.

[30]  R. Lehmann,et al.  Determination of anteroposterior polarity in Drosophila. , 1987, Science.

[31]  F. Turner,et al.  A development genetic analysis of the gene regulator of postbithorax in Drosophila melanogaster. , 1987, Developmental biology.

[32]  T. Schüpbach.  Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster , 1987, Cell.

[33]  M. Haenlin,et al.  Oocyte‐specific transcription of fs(1)K10: a Drosophila gene affecting dorsal–ventral developmental polarity , 1987, The EMBO journal.

[34]  W. Gelbart,et al.  Decapentaplegic transcripts are localized along the dorsal‐ventral axis of the Drosophila embryo. , 1987, The EMBO journal.

[35]  M. Frasch,et al.  Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila , 1987, Nature.

[36]  M. Levine,et al.  Molecular characterization of the zerknüllt region of the Antennapedia gene complex in Drosophila. , 1987, Genes & development.

[37]  J. L. Boulay,et al.  The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers , 1987, Nature.

[38]  R. Steward.  Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel. , 1987, Science.

[39]  B. Thisse,et al.  Genes of the Drosophila maternal dorsal group control the specific expression of the zygotic gene twist in presumptive mesodermal cells , 1987 .

[40]  E Seifert,et al.  Differential regulation of the two transcripts from the Drosophila gap segmentation gene hunchback. , 1988, The EMBO journal.

[41]  R. Lehmann,et al.  Drosophila nurse cells produce a posterior signal required for embryonic segmentation and polarity , 1988, Nature.

[42]  D. Baltimore,et al.  Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor , 1988, Cell.

[43]  D. Baltimore,et al.  I kappa B: a specific inhibitor of the NF-kappa B transcription factor. , 1988, Science.

[44]  R. Steward,et al.  The dorsal protein is distributed in a gradient in early drosophila embryos , 1988, Cell.

[45]  D Bopp,et al.  The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. , 1988, The EMBO journal.

[46]  K. Anderson,et al.  The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein , 1988, Cell.

[47]  J. Lengyel,et al.  Graded requirement for the zygotic terminal gene, tailless, in the brain and tail region of the Drosophila embryo. , 1988, Development.

[48]  H. Jäckle,et al.  Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps , 1988, Nature.

[49]  Diethard Tautz,et al.  Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres , 1988, Nature.

[50]  C. Nüsslein-Volhard,et al.  The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner , 1988, Cell.

[51]  J. Fackenthal,et al.  Molecular analysis of the swallow gene of Drosophila melanogaster. , 1988, Genes & development.

[52]  B. Thisse,et al.  Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. , 1988, The EMBO journal.

[53]  Y. Jan,et al.  Identification of a component of Drosophila polar granules. , 1988, Development.

[54]  C. Nüsslein-Volhard,et al.  A gradient of bicoid protein in Drosophila embryos , 1988, Cell.

[55]  G. Struhl,et al.  Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos , 1988, Nature.

[56]  A. Mahowald,et al.  Developmental genetics of the gastrulation defective locus in Drosophila melanogaster. , 1988, Developmental biology.

[57]  C. Nüsslein-Volhard,et al.  Function of torso in determining the terminal anlagen of the Drosophila embryo , 1988, Nature.

[58]  Y. Nishizuka,et al.  Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto‐oncogene. , 1988, The EMBO journal.

[59]  K. Fujikawa,et al.  The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[60]  V. Pirrotta,et al.  A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila. , 1989, The EMBO journal.

[61]  T. Schüpbach,et al.  The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog , 1989, Cell.

[62]  Wolfgang Driever,et al.  Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen , 1989, Nature.

[63]  H. Jäckle,et al.  Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Krüppel gene expression in the Drosophila blastoderm embryo. , 1989, Development.

[64]  T. Schüpbach,et al.  cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo. , 1989, Genes & development.

[65]  M. Levine,et al.  The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila , 1989, Cell.

[66]  N. Perrimon,et al.  Requirement of the Drosophila raf homologue for torso function , 1989, Nature.

[67]  E. Wieschaus,et al.  Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. , 1989, Genetics.

[68]  Diethard Tautz,et al.  Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene , 1989, Nature.

[69]  B. Shilo,et al.  The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development , 1989, Cell.

[70]  K. Anderson,et al.  The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo , 1989, Cell.

[71]  G. Struhl,et al.  Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos , 1989, Cell.

[72]  Claude Desplan,et al.  The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters , 1989, Nature.

[73]  E. Sánchez-Herrero,et al.  Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis , 1989, Nature.

[74]  Ruth Lehmann,et al.  The Drosophila posterior-group gene nanos functions by repressing hunchback activity , 1989, Nature.

[75]  H. Jäckle,et al.  Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryo , 1989, Nature.

[76]  J. Suttles,et al.  Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein , 1989, Molecular and cellular biology.

[77]  H. Lipshitz,et al.  Reciprocal effects of hyper- and hypoactivity mutations in the Drosophila pattern gene torso. , 1989, Science.

[78]  Wolfgang Driever,et al.  The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo , 1989, Nature.

[79]  M. Levine,et al.  Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila. , 1989, Genes & development.

[80]  C. Nüsslein-Volhard,et al.  The Drosophila gene torso encodes a putative receptor tyrosine kinase , 1989, Nature.

[81]  U. Nauber,et al.  Three hormone receptor‐like Drosophila genes encode an identical DNA‐binding finger. , 1989, The EMBO journal.

[82]  G. Struhl,et al.  Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos , 1989, Nature.

[83]  K. Struhl,et al.  The gradient morphogen bicoid is a concentration-dependent transcriptional activator , 1989, Cell.

[84]  C. Nüsslein-Volhard,et al.  Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte. , 1989, Development.

[85]  S. Mizel,et al.  In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C , 1989, Molecular and cellular biology.

[86]  R. Steward.  Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function , 1989, Cell.

[87]  Michael Levine,et al.  Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila , 1989, Nature.

[88]  G. Struhl,et al.  Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila. , 1989, Genes & development.

[89]  W. McGinnis,et al.  Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo. , 1989, Genes & development.

[90]  P. Seeburg,et al.  Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. , 1989, Science.

[91]  W. Singer,et al.  Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties , 1989, Nature.

[92]  C. Nüsslein-Volhard,et al.  A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo , 1989, Cell.

[93]  M. Ashburner,et al.  Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development. , 1990, Genes & development.

[94]  C. Nüsslein-Volhard,et al.  Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo , 1990, Nature.

[95]  M Klingler,et al.  Two gap genes mediate maternal terminal pattern information in Drosophila. , 1990, Science.

[96]  D. Baltimore,et al.  Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB" , 1990, Nature.

[97]  Y. Jan,et al.  Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. , 1990, Development.

[98]  S. Cohen,et al.  Mediation of Drosophila head development by gap-like segmentation genes , 1990, Nature.

[99]  N. Gay,et al.  The Drosophila membrane receptor Toll can function to promote cellular adhesion. , 1990, The EMBO journal.

[100]  Robert J. Diaz,et al.  The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily , 1990, Cell.

[101]  A. Simeone,et al.  Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells , 1990, Nature.

[102]  J. Massagué,et al.  The transforming growth factor-beta family. , 1990, Annual review of cell biology.

[103]  M. Leptin,et al.  Cell shape changes during gastrulation in Drosophila. , 1990, Development.

[104]  C. Nüsslein-Volhard,et al.  Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. , 1990, Development.

[105]  J. Smith,et al.  Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate , 1990, Nature.

[106]  Diethard Tautz,et al.  A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo , 1990, Nature.

[107]  A. Israël,et al.  The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product , 1990, Cell.

[108]  K. Anderson,et al.  Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain , 1990, Cell.

[109]  G. Nolan,et al.  Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal , 1990, Cell.

[110]  Norbert Perrimon,et al.  The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development , 1990, Nature.

[111]  R. Houghten,et al.  Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. , 1990, The Journal of biological chemistry.

[112]  S. Bryant,et al.  Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud , 1991, Nature.

[113]  V. Pirrotta,et al.  Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes. , 1991, Development.

[114]  S. Wasserman,et al.  Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[115]  Daniel St Johnston,et al.  staufen, a gene required to localize maternal RNAs in the Drosophila egg , 1991, Cell.

[116]  Rapp Ur.  Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. , 1991 .

[117]  J. Brockes.  We may not have a morphogen , 1991, Nature.

[118]  U. Rapp.  Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. , 1991, Oncogene.

[119]  N. Gay,et al.  Drosophila Toll and IL-1 receptor , 1991, Nature.

[120]  E C Stephenson,et al.  Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis. , 1991, Development.

[121]  J. D. Huang,et al.  Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region. , 1991, Genes & development.

[122]  M. Levine,et al.  Spatial regulation of the gap gene giant during Drosophila development. , 1991, Development.

[123]  K. Anderson,et al.  Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. , 1991, Genes & development.

[124]  D Kosman,et al.  The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. , 1991, Genes & development.

[125]  K. Anderson,et al.  Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation. , 1991, Development.

[126]  R. Lehmann,et al.  The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo. , 1991, Development.

[127]  W. Haser,et al.  Raf-1: A kinase currently without a cause but not lacking in effects , 1991, Cell.

[128]  Ruth Lehmann,et al.  Nanos is the localized posterior determinant in Drosophila , 1991, Cell.

[129]  S. Noji,et al.  Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud , 1991, Nature.

[130]  B. Thisse,et al.  Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product , 1991, Cell.

[131]  Y. Jan,et al.  Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila , 1991, Cell.

[132]  P. Distefano,et al.  trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor , 1991, Cell.

[133]  S. Ruben,et al.  Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. , 1991, Science.

[134]  P. Macdonald,et al.  oskar mRNA is localized to the posterior pole of the Drosophila oocyte , 1991, Cell.

[135]  R. Lehmann,et al.  oskar organizes the germ plasm and directs localization of the posterior determinant nanos , 1991, Cell.

[136]  Developmental biology. We may not have a morphogen. , 1991, Nature.

[137]  M. Levine,et al.  The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila , 1991, Cell.

[138]  S. Roth,et al.  The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal , 1991, Cell.

[139]  M. Levine,et al.  Mutually repressive interactions between the gap genes giant and Krüppel define middle body regions of the Drosophila embryo. , 1991, Development.

[140]  J. C. Steichen,et al.  Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos. , 1991, Development.

[141]  G. Struhl,et al.  RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos , 1991, Cell.

[142]  C. Nüsslein-Volhard,et al.  cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. , 1991, Development.

[143]  T. Hunter,et al.  The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor , 1991, Cell.

[144]  G. Nolan,et al.  DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide , 1991, Cell.

[145]  William McGinnis,et al.  Homeobox genes and axial patterning , 1992, Cell.

[146]  C. Nüsslein-Volhard,et al.  Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity , 1992, Cell.

[147]  AC Tose.  Cell , 1993, Cell.