Radiosynthesis of 2'-deoxy-2'-[18F]-fluoro-5-methyl-1-beta-L-arabinofuranosyluracil ([18F]-L-FMAU) for PET.
暂无分享,去创建一个
[1] H. Yoo,et al. Rapid Quantitative Determination of L-FMAU-TP from Human Peripheral-Blood Mononuclear Cells of Hepatitis B Virus-Infected Patients Treated with L-FMAU by Ion-Pairing, Reverse-Phase, Liquid Chromatography/Electrospray Tandem Mass Spectrometry , 2006, Therapeutic drug monitoring.
[2] B. Degrève,et al. Behavior of Thymidylate Kinase toward Monophosphate Metabolites and Its Role in the Metabolism of 1-(2′-Deoxy-2′-Fluoro-β-l-Arabinofuranosyl)-5-Methyluracil (Clevudine) and 2′,3′-Didehydro-2′,3′-Dideoxythymidine in Cells , 2005, Antimicrobial Agents and Chemotherapy.
[3] J. Bading,et al. Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats. , 2004, Nuclear medicine and biology.
[4] P. Conti,et al. Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model. , 2004, Molecular imaging.
[5] O. Muzik,et al. Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer , 2004, European Journal of Nuclear Medicine and Molecular Imaging.
[6] A. Shields,et al. Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU. , 2003, Nuclear medicine and biology.
[7] G. Peters,et al. Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. , 2003, European journal of cancer.
[8] C. K. Chu,et al. Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies. , 2002, Bioorganic & medicinal chemistry letters.
[9] P. Conti,et al. Synthesis of [18F]‐labeled 2′‐deoxy‐2′‐fluoro‐5‐methyl‐1‐β‐D‐arabinofuranosyluracil ([18F]‐FMAU) , 2002 .
[10] I. Kocić. Clevudine University of Georgia/Abbott/Bukwang/Triangle/Yale University. , 2000, Current opinion in investigational drugs.
[11] P. Conti,et al. Stereospecific fluorination of 1,3,5-tri-O-benzoyl-α-D-ribofuranose-2-sulfonate esters: Preparation of a versatile intermediate for synthesis of 2′-[ 18F ]-fluoro-arabinonucleosides , 2000 .
[12] Shwu-Huey Liu,et al. Unique Metabolism of a Novel Antivirall-Nucleoside Analog, 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil: a Substrate for Both Thymidine Kinase and Deoxycytidine Kinase , 1998, Antimicrobial Agents and Chemotherapy.
[13] Y. Cheng,et al. Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent. , 1998, Antiviral therapy.
[14] Y. L. Zhu,et al. Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents. , 1996, Journal of medicinal chemistry.
[15] Y. L. Zhu,et al. Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil , 1996, Antimicrobial agents and chemotherapy.
[16] P. Conti,et al. Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET. , 1995, Nuclear medicine and biology.
[17] Y. Cheng,et al. Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus , 1995, Antimicrobial agents and chemotherapy.
[18] J. Sherley,et al. Regulation of human thymidine kinase during the cell cycle. , 1988, The Journal of biological chemistry.
[19] H. G. Howell,et al. Fluorocarbohydrates in synthesis. An efficient synthesis of 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (.beta.-FIAU) and 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)thymine (.beta.-FMAU) , 1985 .
[20] K. Watanabe,et al. NUCLEOSIDES. 129. SYNTHESIS OF ANTIVIRAL NUCLEOSIDES: 5-ALKENYL-1-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)URACILS , 1984 .
[21] K. Watanabe,et al. Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils. , 1984, Journal of medicinal chemistry.
[22] K. Watanabe,et al. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. , 1979, Journal of medicinal chemistry.